PubMed

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet.

Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB, Wheeler MB.

Diabetes. 2002 Nov;51(11):3211-9.PMID: 12401712 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB.

Cell. 2001 Jun 15;105(6):745-55.PMID: 11440717 [PubMed - indexed for MEDLINE]Related articles

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F.

Diabetes. 2001 Apr;50(4):803-9.PMID: 11289045 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice.

Ahrén B, Simonsson E, Scheurink AJ, Mulder H, Myrsén U, Sundler F.

Metabolism. 1997 Jan;46(1):97-106.PMID: 9005977 [PubMed - indexed for MEDLINE]Related articles

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB.

J Clin Invest. 2003 Dec;112(12):1831-42.PMID: 14679178 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel model of type 2 diabetes mellitus based on obesity induced by high-fat diet in BDF1 mice.

Karasawa H, Nagata-Goto S, Takaishi K, Kumagae Y.

Metabolism. 2009 Mar;58(3):296-303.PMID: 19217442 [PubMed - indexed for MEDLINE]Related articles

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB.

Diabetes. 2001 Jun;50(6):1302-10.PMID: 11375330 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of uncoupling protein 2 in the development of type 2 diabetes.

Langin D.

Drugs Today (Barc). 2003 Apr;39(4):287-95. Review.PMID: 12743644 [PubMed - indexed for MEDLINE]Related articles

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets.

Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr, Lowell BB.

Cell Metab. 2006 Jun;3(6):417-27.PMID: 16753577 [PubMed - indexed for MEDLINE]Related articles

[Relationship between islet beta cell dysfunction and gene expression of uncoupling protein-2 and possible mechanism thereof]

Wang B, Li HL, Yang WY, Xiao JZ, Du RQ, Bai XP, Lou DJ, Pan L.

Zhonghua Yi Xue Za Zhi. 2008 Mar 4;88(9):630-4. Chinese. PMID: 18646721 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin secretion by uncoupling protein.

Chan CB, Kashemsant N.

Biochem Soc Trans. 2006 Nov;34(Pt 5):802-5.PMID: 17052202 [PubMed - indexed for MEDLINE]Related articles

Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

Produit-Zengaffinen N, Davis-Lameloise N, Perreten H, Bécard D, Gjinovci A, Keller PA, Wollheim CB, Herrera P, Muzzin P, Assimacopoulos-Jeannet F.

Diabetologia. 2007 Jan;50(1):84-93. Epub 2006 Nov 28.PMID: 17131143 [PubMed - indexed for MEDLINE]Related articles

Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin.

Lee SC, Robson-Doucette CA, Wheeler MB.

J Endocrinol. 2009 Oct;203(1):33-43. Epub 2009 Jul 27.PMID: 19635759 [PubMed - indexed for MEDLINE]Related articles

The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.

Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V.

Diabetes. 2008 Sep;57(9):2432-7. Epub 2008 Jun 16. Erratum in: Diabetes. 2008 Nov;57(11):3166. PMID: 18559658 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2.

Baffy G, Zhang CY, Glickman JN, Lowell BB.

Hepatology. 2002 Apr;35(4):753-61.PMID: 11915020 [PubMed - indexed for MEDLINE]Related articles

Endogenous regulation of insulin secretion by UCP2.

Chan CB.

Clin Lab. 2002;48(11-12):599-604. Review.PMID: 12465744 [PubMed - indexed for MEDLINE]Related articles

Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.

Winzell MS, Brand CL, Wierup N, Sidelmann UG, Sundler F, Nishimura E, Ahrén B.

Diabetologia. 2007 Jul;50(7):1453-62. Epub 2007 May 4.PMID: 17479245 [PubMed - indexed for MEDLINE]Related articles

Durable islet effects on insulin secretion and protein kinase A expression following exendin-4 treatment of high-fat diet-fed mice.

Winzell MS, Ahrén B.

J Mol Endocrinol. 2008 Feb;40(2):93-100.PMID: 18234911 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein 2 and islet function.

Chan CB, Saleh MC, Koshkin V, Wheeler MB.

Diabetes. 2004 Feb;53 Suppl 1:S136-42. Review.PMID: 14749279 [PubMed - indexed for MEDLINE]Related articlesFree article