PubMed

Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue.

Chen HC, Stone SJ, Zhou P, Buhman KK, Farese RV Jr.

Diabetes. 2002 Nov;51(11):3189-95.PMID: 12401709 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1.

Chen HC, Jensen DR, Myers HM, Eckel RH, Farese RV Jr.

J Clin Invest. 2003 Jun;111(11):1715-22.PMID: 12782674 [PubMed - indexed for MEDLINE]Related articlesFree article

Whole-body insulin resistance in the absence of obesity in FVB mice with overexpression of Dgat1 in adipose tissue.

Chen N, Liu L, Zhang Y, Ginsberg HN, Yu YH.

Diabetes. 2005 Dec;54(12):3379-86.PMID: 16306352 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.

Chen HC, Rao M, Sajan MP, Standaert M, Kanoh Y, Miura A, Farese RV Jr, Farese RV.

Diabetes. 2004 Jun;53(6):1445-51.PMID: 15161747 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.

Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV Jr.

J Clin Invest. 2002 Apr;109(8):1049-55.PMID: 11956242 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of DGAT2 in white adipose tissue is regulated by central leptin action.

Suzuki R, Tobe K, Aoyama M, Sakamoto K, Ohsugi M, Kamei N, Nemoto S, Inoue A, Ito Y, Uchida S, Hara K, Yamauchi T, Kubota N, Terauchi Y, Kadowaki T.

J Biol Chem. 2005 Feb 4;280(5):3331-7. Epub 2004 Nov 18.PMID: 15550388 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.

Chen HC, Farese RV Jr.

Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):482-6. Epub 2004 Nov 29. Review.PMID: 15569818 [PubMed - indexed for MEDLINE]Related articlesFree article

High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance.

Gnudi L, Tozzo E, Shepherd PR, Bliss JL, Kahn BB.

Endocrinology. 1995 Mar;136(3):995-1002.PMID: 7867610 [PubMed - indexed for MEDLINE]Related articles

Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models.

Chen HC, Ladha Z, Farese RV Jr.

Endocrinology. 2002 Aug;143(8):2893-8.PMID: 12130553 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.

Streeper RS, Koliwad SK, Villanueva CJ, Farese RV Jr.

Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E388-94. Epub 2006 Apr 4.PMID: 16595853 [PubMed - indexed for MEDLINE]Related articlesFree article

The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment.

Ranganathan G, Unal R, Pokrovskaya I, Yao-Borengasser A, Phanavanh B, Lecka-Czernik B, Rasouli N, Kern PA.

J Lipid Res. 2006 Nov;47(11):2444-50. Epub 2006 Aug 7.PMID: 16894240 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1.

Yamazaki T, Sasaki E, Kakinuma C, Yano T, Miura S, Ezaki O.

J Biol Chem. 2005 Jun 3;280(22):21506-14. Epub 2005 Mar 29.PMID: 15797871 [PubMed - indexed for MEDLINE]Related articlesFree article

Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance.

Liu L, Zhang Y, Chen N, Shi X, Tsang B, Yu YH.

J Clin Invest. 2007 Jun;117(6):1679-89. Epub 2007 May 17.PMID: 17510710 [PubMed - indexed for MEDLINE]Related articlesFree article

Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin.

Meegalla RL, Billheimer JT, Cheng D.

Biochem Biophys Res Commun. 2002 Nov 1;298(3):317-23.PMID: 12413942 [PubMed - indexed for MEDLINE]Related articles

Improved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet.

Wang SJ, Cornick C, O'Dowd J, Cawthorne MA, Arch JR.

Lipids Health Dis. 2007 Jan 19;6:2.PMID: 17239230 [PubMed - indexed for MEDLINE]Related articlesFree article

Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes.

Yu YH, Zhang Y, Oelkers P, Sturley SL, Rader DJ, Ginsberg HN.

J Biol Chem. 2002 Dec 27;277(52):50876-84. Epub 2002 Oct 28.PMID: 12407108 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase.

Terauchi Y, Matsui J, Kamon J, Yamauchi T, Kubota N, Komeda K, Aizawa S, Akanuma Y, Tomita M, Kadowaki T.

Diabetes. 2004 Sep;53(9):2261-70.PMID: 15331535 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.

Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV Jr.

Nat Genet. 2000 May;25(1):87-90.PMID: 10802663 [PubMed - indexed for MEDLINE]Related articles

Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice.

Harada K, Shen WJ, Patel S, Natu V, Wang J, Osuga J, Ishibashi S, Kraemer FB.

Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1182-95. Epub 2003 Sep 3.PMID: 12954598 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancing energy and glucose metabolism by disrupting triglyceride synthesis: Lessons from mice lacking DGAT1.

Chen HC.

Nutr Metab (Lond). 2006 Jan 31;3:10.PMID: 16448557 [PubMed - in process]Related articlesFree article