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    Results: 1 to 20 of 149

    1.

    Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.

    't Hart LM, van Haeften TW, Dekker JM, Bot M, Heine RJ, Maassen JA.

    Diabetes. 2002 Oct;51(10):3135-8.PMID: 12351459 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus.

    Hart LM, Dekker JM, van Haeften TW, Ruige JB, Stehouwer CD, Erkelens DW, Heine RJ, Maassen JA.

    Diabetologia. 2000 Apr;43(4):515-9.PMID: 10819247 [PubMed - indexed for MEDLINE]Related articles

    3.

    Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.

    Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS.

    Diabetes. 2009 Aug;58(8):1869-78. Epub 2009 Jun 2.PMID: 19491206 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion.

    Huopio H, Vauhkonen I, Komulainen J, Niskanen L, Otonkoski T, Laakso M.

    Diabetes Care. 2002 Jan;25(1):101-6.PMID: 11772909 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

    Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.

    Diabetes. 2003 Feb;52(2):568-72.PMID: 12540637 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

    Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

    Diabetes. 2004 May;53(5):1360-8.PMID: 15111507 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes.

    Elbein SC, Sun J, Scroggin E, Teng K, Hasstedt SJ.

    Diabetes Care. 2001 Mar;24(3):472-8.PMID: 11289470 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

    't Hart LM, Nijpels G, Dekker JM, Maassen JA, Heine RJ, van Haeften TW.

    Diabetes. 2002 Mar;51(3):884-7.PMID: 11872698 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).

    Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC; UK Prospective Diabetes Study (UKPDS 53).

    Diabet Med. 2001 Mar;18(3):206-12. Erratum in: Diabet Med. 2003 Mar;20(3):252.. PMID: 11318841 [PubMed - indexed for MEDLINE]Related articles

    10.

    The E23K variant in the Kir6.2 subunit of the ATP-sensitive K+ channel does not augment impaired glucose tolerance in Caribbean subjects with a family history of type 2 diabetes.

    Ezenwaka C, Kalloo R, Uhlig M, Schwenk R, Eckel J.

    J Endocrinol. 2005 Jun;185(3):439-44.PMID: 15930170 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians.

    Hani EH, Boutin P, Durand E, Inoue H, Permutt MA, Velho G, Froguel P.

    Diabetologia. 1998 Dec;41(12):1511-5.PMID: 9867219 [PubMed - indexed for MEDLINE]Related articles

    12.

    Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses.

    van Dam RM, Hoebee B, Seidell JC, Schaap MM, de Bruin TW, Feskens EJ.

    Diabet Med. 2005 May;22(5):590-8.PMID: 15842514 [PubMed - indexed for MEDLINE]Related articles

    13.

    Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.

    Hansen T, Echwald SM, Hansen L, Møller AM, Almind K, Clausen JO, Urhammer SA, Inoue H, Ferrer J, Bryan J, Aguilar-Bryan L, Permutt MA, Pedersen O.

    Diabetes. 1998 Apr;47(4):598-605.PMID: 9568693 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM.

    Hansen L, Echwald SM, Hansen T, Urhammer SA, Clausen JO, Pedersen O.

    Diabetes. 1997 Mar;46(3):508-12.PMID: 9032110 [PubMed - indexed for MEDLINE]Related articles

    15.

    A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.

    Tarasov AI, Nicolson TJ, Riveline JP, Taneja TK, Baldwin SA, Baldwin JM, Charpentier G, Gautier JF, Froguel P, Vaxillaire M, Rutter GA.

    Diabetes. 2008 Jun;57(6):1595-604. Epub 2008 Mar 17.PMID: 18346985 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans.

    Palmer ND, Langefeld CD, Bryer-Ash M, Rotter JI, Taylor KD, Bowden DW.

    J Clin Endocrinol Metab. 2008 Dec;93(12):4979-83. Epub 2008 Sep 16.PMID: 18796522 [PubMed - indexed for MEDLINE]Related articles

    17.

    The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

    Sesti G, Laratta E, Cardellini M, Andreozzi F, Del Guerra S, Irace C, Gnasso A, Grupillo M, Lauro R, Hribal ML, Perticone F, Marchetti P.

    J Clin Endocrinol Metab. 2006 Jun;91(6):2334-9. Epub 2006 Apr 4.PMID: 16595597 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Sulfonylurea receptor -1 (SUR1): genetic and metabolic evidences for a role in the susceptibility to type 2 diabetes mellitus.

    Reis AF, Velho G.

    Diabetes Metab. 2002 Feb;28(1):14-9.PMID: 11938023 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus.

    Hansen T, Ambye L, Grarup N, Hansen L, Echwald SM, Ferrer J, Pedersen O.

    Diabetologia. 2001 Oct;44(10):1330-4.PMID: 11692183 [PubMed - indexed for MEDLINE]Related articles

    20.

    Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin.

    Rissanen J, Markkanen A, Kärkkäinen P, Pihlajamäki J, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Laakso M.

    Diabetes Care. 2000 Jan;23(1):70-3.PMID: 10857971 [PubMed - indexed for MEDLINE]Related articlesFree article

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