PubMed

A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels.

van Rossum EF, Koper JW, Huizenga NA, Uitterlinden AG, Janssen JA, Brinkmann AO, Grobbee DE, de Jong FH, van Duyn CM, Pols HA, Lamberts SW.

Diabetes. 2002 Oct;51(10):3128-34.PMID: 12351458 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition.

van Rossum EF, Lamberts SW.

Recent Prog Horm Res. 2004;59:333-57. Review.PMID: 14749509 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms.

van Rossum EF, Roks PH, de Jong FH, Brinkmann AO, Pols HA, Koper JW, Lamberts SW.

Clin Endocrinol (Oxf). 2004 Nov;61(5):573-81.PMID: 15521959 [PubMed - indexed for MEDLINE]Related articles

Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study.

Kuningas M, Mooijaart SP, Slagboom PE, Westendorp RG, van Heemst D.

Biogerontology. 2006 Aug;7(4):231-8. Epub 2006 May 5.PMID: 16676134 [PubMed - indexed for MEDLINE]Related articles

The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults.

van Rossum EF, Voorhoeve PG, te Velde SJ, Koper JW, Delemarre-van de Waal HA, Kemper HC, Lamberts SW.

J Clin Endocrinol Metab. 2004 Aug;89(8):4004-9.PMID: 15292341 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men.

van Rossum EF, Feelders RA, van den Beld AW, Uitterlinden AG, Janssen JA, Ester W, Brinkmann AO, Grobbee DE, de Jong FH, Pols HA, Koper JW, Lamberts SW.

Am J Med. 2004 Aug 1;117(3):158-62.PMID: 15276593 [PubMed - indexed for MEDLINE]Related articles

Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index.

van Rossum EF, Koper JW, van den Beld AW, Uitterlinden AG, Arp P, Ester W, Janssen JA, Brinkmann AO, de Jong FH, Grobbee DE, Pols HA, Lamberts SW.

Clin Endocrinol (Oxf). 2003 Nov;59(5):585-92.PMID: 14616881 [PubMed - indexed for MEDLINE]Related articles

A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo.

Huizenga NA, Koper JW, De Lange P, Pols HA, Stolk RP, Burger H, Grobbee DE, Brinkmann AO, De Jong FH, Lamberts SW.

J Clin Endocrinol Metab. 1998 Jan;83(1):144-51.PMID: 9435432 [PubMed - indexed for MEDLINE]Related articlesFree article

The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients.

Di Blasio AM, van Rossum EF, Maestrini S, Berselli ME, Tagliaferri M, Podestà F, Koper JW, Liuzzi A, Lamberts SW.

Clin Endocrinol (Oxf). 2003 Jul;59(1):68-74.PMID: 12807506 [PubMed - indexed for MEDLINE]Related articles

Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals.

Huizenga NA, Koper JW, de Lange P, Pols HA, Stolk RP, Grobbee DE, de Jong FH, Lamberts SW.

J Clin Endocrinol Metab. 1998 Jan;83(1):47-54.PMID: 9435415 [PubMed - indexed for MEDLINE]Related articlesFree article

A glucocorticoid receptor gene haplotype (TthIII1/ER22/23EK/9beta) is associated with a more aggressive disease course in multiple sclerosis.

van Winsen LM, Manenschijn L, van Rossum EF, Crusius JB, Koper JW, Polman CH, Uitdehaag BM.

J Clin Endocrinol Metab. 2009 Jun;94(6):2110-4. Epub 2009 Mar 24. Erratum in: J Clin Endocrinol Metab. 2009 Jul;94(7):2674. Crusius, Bart A [corrected to Crusius, J Bart A]. PMID: 19318444 [PubMed - indexed for MEDLINE]Related articles

Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism.

Russcher H, van Rossum EF, de Jong FH, Brinkmann AO, Lamberts SW, Koper JW.

Mol Endocrinol. 2005 Jul;19(7):1687-96. Epub 2005 Mar 3.PMID: 15746190 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid receptor variant and risk of dementia and white matter lesions.

van Rossum EF, de Jong FJ, Koper JW, Uitterlinden AG, Prins ND, van Dijk EJ, Koudstaal PJ, Hofman A, de Jong FH, Lamberts SW, Breteler MM.

Neurobiol Aging. 2008 May;29(5):716-23. Epub 2006 Dec 20.PMID: 17184882 [PubMed - indexed for MEDLINE]Related articles

A functional polymorphism in the glucocorticoid receptor gene and its relation to cardiovascular disease risk in familial hypercholesterolemia.

Koeijvoets KC, van Rossum EF, Dallinga-Thie GM, Steyerberg EW, Defesche JC, Kastelein JJ, Lamberts SW, Sijbrands EJ.

J Clin Endocrinol Metab. 2006 Oct;91(10):4131-6. Epub 2006 Jul 18.PMID: 16849409 [PubMed - indexed for MEDLINE]Related articlesFree article

Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.

Kumsta R, Entringer S, Koper JW, van Rossum EF, Hellhammer DH, Wüst S.

Biol Psychiatry. 2007 Oct 15;62(8):863-9. Epub 2007 Aug 23.PMID: 17716631 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms of the glucocorticoid receptor gene and major depression.

van Rossum EF, Binder EB, Majer M, Koper JW, Ising M, Modell S, Salyakina D, Lamberts SW, Holsboer F.

Biol Psychiatry. 2006 Apr 15;59(8):681-8.PMID: 16580345 [PubMed - indexed for MEDLINE]Related articles

Glucocorticoid receptor polymorphism affects transrepression but not transactivation.

van den Akker EL, Russcher H, van Rossum EF, Brinkmann AO, de Jong FH, Hokken A, Pols HA, Koper JW, Lamberts SW.

J Clin Endocrinol Metab. 2006 Jul;91(7):2800-3. Epub 2006 May 9.PMID: 16684836 [PubMed - indexed for MEDLINE]Related articlesFree article

Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression.

Russcher H, Smit P, van den Akker EL, van Rossum EF, Brinkmann AO, de Jong FH, Lamberts SW, Koper JW.

J Clin Endocrinol Metab. 2005 Oct;90(10):5804-10. Epub 2005 Jul 19.PMID: 16030164 [PubMed - indexed for MEDLINE]Related articlesFree article

Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression.

Brouwer JP, Appelhof BC, van Rossum EF, Koper JW, Fliers E, Huyser J, Schene AH, Tijssen JG, Van Dyck R, Lamberts SW, Wiersinga WM, Hoogendijk WJ.

Psychoneuroendocrinology. 2006 Nov;31(10):1154-63. Epub 2006 Oct 10.PMID: 17034955 [PubMed - indexed for MEDLINE]Related articles

Intima media thickness of carotid arteries is reduced in heterozygous carriers of the Gly972Arg variant in the insulin receptor substrate-1 gene.

Hölzl B, Iglseder B, Stadlmayr A, Hedegger M, Moré E, Reiter R, Sandhofer F, Paulweber B.

Eur J Clin Invest. 2003 Feb;33(2):110-6.PMID: 12588284 [PubMed - indexed for MEDLINE]Related articles