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Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat.
Zagon IS, Jenkins JB, Sassani JW, Wylie JD, Ruth TB, Fry JL, Lang CM, McLaughlin PJ.
Diabetes. 2002 Oct;51(10):3055-62.PMID: 12351447 [PubMed - indexed for MEDLINE]Related articlesFree article
Topically applied naltrexone restores corneal reepithelialization in diabetic rats.
Klocek MS, Sassani JW, McLaughlin PJ, Zagon IS.
J Ocul Pharmacol Ther. 2007 Apr;23(2):89-102.PMID: 17444796 [PubMed - indexed for MEDLINE]Related articles
Reepithelialization of the human cornea is regulated by endogenous opioids.
Zagon IS, Sassani JW, McLaughlin PJ.
Invest Ophthalmol Vis Sci. 2000 Jan;41(1):73-81.PMID: 10634604 [PubMed - indexed for MEDLINE]Related articlesFree article
Naltrexone accelerates healing without compromise of adhesion complexes in normal and diabetic corneal epithelium.
Zagon IS, Sassani JW, Myers RL, McLaughlin PJ.
Brain Res Bull. 2007 Apr 2;72(1):18-24. Epub 2007 Jan 8.PMID: 17303503 [PubMed - indexed for MEDLINE]Related articles
Re-epithelialization of the rat cornea is accelerated by blockade of opioid receptors.
Brain Res. 1998 Jul 6;798(1-2):254-60.PMID: 9666142 [PubMed - indexed for MEDLINE]Related articles
Adaptation of homeostatic ocular surface epithelium to chronic treatment with the opioid antagonist naltrexone.
Cornea. 2006 Aug;25(7):821-9.PMID: 17068460 [PubMed - indexed for MEDLINE]Related articles
Prevention of exuberant granulation tissue and neovascularization in the rat cornea by naltrexone.
Zagon IS, Klocek MS, Griffith JW, Sassani JW, Komáromy AM, McLaughlin PJ.
Arch Ophthalmol. 2008 Apr;126(4):501-6.PMID: 18413519 [PubMed - indexed for MEDLINE]Related articlesFree article
Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats.
Diabetes. 2006 Apr;55(4):1141-7.PMID: 16567540 [PubMed - indexed for MEDLINE]Related articlesFree article
Homeostasis of ocular surface epithelium in the rat is regulated by opioid growth factor.
Zagon IS, Sassani JW, Kane ER, McLaughlin PJ.
Brain Res. 1997 Jun 6;759(1):92-102.PMID: 9219867 [PubMed - indexed for MEDLINE]Related articles
Re-epithelialization of the rabbit cornea is regulated by opioid growth factor.
Brain Res. 1998 Aug 24;803(1-2):61-8.PMID: 9729280 [PubMed - indexed for MEDLINE]Related articles
Gene-peptide relationships in the developing rat brain: the response of preproenkephalin mRNA and [Met5]-enkephalin to acute opioid antagonist (naltrexone) exposure.
Zagon IS, McLaughlin PJ.
Brain Res Mol Brain Res. 1995 Oct;33(1):111-20.PMID: 8774952 [PubMed - indexed for MEDLINE]Related articles
Corneal safety of topically applied naltrexone.
Zagon IS, Klocek MS, Sassani JW, Mauger DT, McLaughlin PJ.
J Ocul Pharmacol Ther. 2006 Oct;22(5):377-87.PMID: 17076633 [PubMed - indexed for MEDLINE]Related articles
Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus.
Zagon IS, Klocek MS, Sassani JW, McLaughlin PJ.
Arch Ophthalmol. 2007 Aug;125(8):1082-8.PMID: 17698755 [PubMed - indexed for MEDLINE]Related articlesFree article
Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus.
Arch Ophthalmol. 2009 Nov;127(11):1468-73.PMID: 19901212 [PubMed - indexed for MEDLINE]Related articles
Opioid growth factor inhibits intimal hyperplasia in balloon-injured rat carotid artery.
Zagon IS, Essis FM Jr, Verderame MF, Healy DA, Atnip RG, McLaughlin PJ.
J Vasc Surg. 2003 Mar;37(3):636-43.PMID: 12618704 [PubMed - indexed for MEDLINE]Related articles
The opioid growth factor, [Met5]-enkephalin, inhibits DNA synthesis during recornification of mouse tail skin.
Wilson RP, McLaughlin PJ, Lang CM, Zagon IS.
Cell Prolif. 2000 Apr;33(2):63-73.PMID: 10845251 [PubMed - indexed for MEDLINE]Related articles
Topical application of naltrexone facilitates reepithelialization of the cornea in diabetic rabbits.
Zagon IS, Sassani JW, Carroll MA, McLaughlin PJ.
Brain Res Bull. 2009 Oct 21. [Epub ahead of print]PMID: 19853024 [PubMed - as supplied by publisher]Related articles
Opioid growth factor modulation of corneal epithelium: uppers and downers.
Sassani JW, Zagon IS, McLaughlin PJ.
Curr Eye Res. 2003 May;26(5):249-62. Review.PMID: 12854052 [PubMed - indexed for MEDLINE]Related articles
Opioid growth factor modulates corneal epithelial outgrowth in tissue culture.
Am J Physiol. 1995 Apr;268(4 Pt 2):R942-50.PMID: 7733405 [PubMed - indexed for MEDLINE]Related articles
Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic rats.
Exp Eye Res. 2009 Nov;89(5):686-92. Epub 2009 Jul 1.PMID: 19576213 [PubMed - in process]Related articles
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