PubMed

Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro.

Cebrian A, García-Ocaña A, Takane KK, Sipula D, Stewart AF, Vasavada RC.

Diabetes. 2002 Oct;51(10):3003-13.PMID: 12351440 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice.

García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC, Stewart AF.

Diabetes. 2001 Dec;50(12):2752-62.PMID: 11723058 [PubMed - indexed for MEDLINE]Related articlesFree article

Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse.

Porter SE, Sorenson RL, Dann P, Garcia-Ocana A, Stewart AF, Vasavada RC.

Endocrinology. 1998 Sep;139(9):3743-51.PMID: 9724026 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic beta-cell survival.

Fujinaka Y, Sipula D, Garcia-Ocaña A, Vasavada RC.

Diabetes. 2004 Dec;53(12):3120-30.PMID: 15561942 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF.

J Biol Chem. 2000 Jan 14;275(2):1226-32.PMID: 10625667 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells.

Welsh M, Christmansson L, Karlsson T, Sandler S, Welsh N.

Mol Med. 1999 Mar;5(3):169-80.PMID: 10404514 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia.

Vasavada RC, Cavaliere C, D'Ercole AJ, Dann P, Burtis WJ, Madlener AL, Zawalich K, Zawalich W, Philbrick W, Stewart AF.

J Biol Chem. 1996 Jan 12;271(2):1200-8.PMID: 8557651 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.

Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S.

Diabetes. 2002 Jun;51(6):1793-804.PMID: 12031967 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death.

Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF.

J Biol Chem. 2003 Jan 3;278(1):343-51. Epub 2002 Oct 25.PMID: 12403787 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential sensitivity of GLUT1- and GLUT2-expressing beta cells to streptozotocin.

Hosokawa M, Dolci W, Thorens B.

Biochem Biophys Res Commun. 2001 Dec 21;289(5):1114-7.PMID: 11741307 [PubMed - indexed for MEDLINE]Related articles

In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4.

Hino S, Yamaoka T, Yamashita Y, Yamada T, Hata J, Itakura M.

Diabetologia. 2004 Oct;47(10):1819-30. Epub 2004 Oct 6.PMID: 15480536 [PubMed - indexed for MEDLINE]Related articles

Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

Vasavada RC, Garcia-Ocaña A, Zawalich WS, Sorenson RL, Dann P, Syed M, Ogren L, Talamantes F, Stewart AF.

J Biol Chem. 2000 May 19;275(20):15399-406.PMID: 10809775 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin.

Annerén C.

J Endocrinol. 2002 Jan;172(1):145-53.PMID: 11786382 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis.

Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocaña A.

Diabetes. 2007 Nov;56(11):2732-43. Epub 2007 Aug 8.PMID: 17686945 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion.

Zhou YP, Pena JC, Roe MW, Mittal A, Levisetti M, Baldwin AC, Pugh W, Ostrega D, Ahmed N, Bindokas VP, Philipson LH, Hanahan D, Thompson CB, Polonsky KS.

Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E340-51.PMID: 10662719 [PubMed - indexed for MEDLINE]Related articlesFree article

Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation.

Fujinaka Y, Takane K, Yamashita H, Vasavada RC.

J Biol Chem. 2007 Oct 19;282(42):30707-17. Epub 2007 Aug 29.PMID: 17728251 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

Endocrinology. 2002 Apr;143(4):1530-7.PMID: 11897712 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice.

Iwakura H, Hosoda K, Son C, Fujikura J, Tomita T, Noguchi M, Ariyasu H, Takaya K, Masuzaki H, Ogawa Y, Hayashi T, Inoue G, Akamizu T, Hosoda H, Kojima M, Itoh H, Toyokuni S, Kangawa K, Nakao K.

J Biol Chem. 2005 Apr 15;280(15):15247-56. Epub 2005 Feb 8.PMID: 15701644 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrín M, Gros L, Bosch F.

J Clin Invest. 2000 Mar;105(6):731-40.PMID: 10727441 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass.

Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocaña A.

Diabetes. 2005 Jul;54(7):2090-102.PMID: 15983210 [PubMed - indexed for MEDLINE]Related articlesFree article