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    Results: 1 to 20 of 127

    1.

    Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota.

    Standaert ML, Ortmeyer HK, Sajan MP, Kanoh Y, Bandyopadhyay G, Hansen BC, Farese RV.

    Diabetes. 2002 Oct;51(10):2936-43.PMID: 12351430 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.

    Beeson M, Sajan MP, Dizon M, Grebenev D, Gomez-Daspet J, Miura A, Kanoh Y, Powe J, Bandyopadhyay G, Standaert ML, Farese RV.

    Diabetes. 2003 Aug;52(8):1926-34.PMID: 12882907 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-zeta/lambda by insulin in vastus lateralis muscles and adipocytes of diabetic rats.

    Kanoh Y, Bandyopadhyay G, Sajan MP, Standaert ML, Farese RV.

    Endocrinology. 2001 Apr;142(4):1595-605.PMID: 11250941 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes.

    Kanoh Y, Sajan MP, Bandyopadhyay G, Miura A, Standaert ML, Farese RV.

    Endocrinology. 2003 Mar;144(3):947-54.PMID: 12586772 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.

    Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB.

    Diabetes. 2003 Aug;52(8):1935-42.PMID: 12882908 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.

    Luna V, Casauban L, Sajan MP, Gomez-Daspet J, Powe JL, Miura A, Rivas J, Standaert ML, Farese RV.

    Diabetologia. 2006 Feb;49(2):375-82. Epub 2006 Jan 5.PMID: 16395615 [PubMed - indexed for MEDLINE]Related articles

    7.

    Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects.

    Sajan MP, Standaert ML, Miura A, Bandyopadhyay G, Vollenweider P, Franklin DM, Lea-Currie R, Farese RV.

    J Clin Endocrinol Metab. 2004 Aug;89(8):3994-8.PMID: 15292339 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states.

    Standaert ML, Sajan MP, Miura A, Kanoh Y, Chen HC, Farese RV Jr, Farese RV.

    J Biol Chem. 2004 Jun 11;279(24):24929-34. Epub 2004 Apr 6.PMID: 15069067 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes.

    Farese RV, Sajan MP, Standaert ML.

    Exp Biol Med (Maywood). 2005 Oct;230(9):593-605. Review.PMID: 16179727 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Insulin-stimulated plasma membrane association and activation of Akt2, aPKC zeta and aPKC lambda in high fat fed rodent skeletal muscle.

    Herr HJ, Bernard JR, Reeder DW, Rivas DA, Limon JJ, Yaspelkis BB 3rd.

    J Physiol. 2005 Jun 1;565(Pt 2):627-36. Epub 2005 Mar 31.PMID: 15802290 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.

    Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM.

    Diabetes. 2005 Aug;54(8):2351-9.PMID: 16046301 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities.

    Tremblay F, Lavigne C, Jacques H, Marette A.

    Diabetes. 2001 Aug;50(8):1901-10.PMID: 11473054 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle.

    Temofonte N, Sajan MP, Nimal S, Pastoor T, Fumero C, Casaubon L, Powe JL, Standaert ML, Farese RV.

    Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30.PMID: 18972094 [PubMed - indexed for MEDLINE]Related articles

    14.

    Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.

    Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB.

    J Clin Invest. 1999 Sep;104(6):733-41.PMID: 10491408 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Dietary cod protein restores insulin-induced activation of phosphatidylinositol 3-kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed obese rats.

    Tremblay F, Lavigne C, Jacques H, Marette A.

    Diabetes. 2003 Jan;52(1):29-37.PMID: 12502490 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans.

    Casaubon L, Sajan MP, Rivas J, Powe JL, Standaert ML, Farese RV.

    Diabetologia. 2006 Dec;49(12):3000-8. Epub 2006 Oct 7.PMID: 17028898 [PubMed - indexed for MEDLINE]Related articles

    17.

    Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice.

    Hori H, Sasaoka T, Ishihara H, Wada T, Murakami S, Ishiki M, Kobayashi M.

    Diabetes. 2002 Aug;51(8):2387-94.PMID: 12145149 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

    Kim YB, Zhu JS, Zierath JR, Shen HQ, Baron AD, Kahn BB.

    Diabetes. 1999 Feb;48(2):310-20.PMID: 10334307 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Atypical protein kinase C in insulin action and insulin resistance.

    Farese RV, Sajan MP, Standaert ML.

    Biochem Soc Trans. 2005 Apr;33(Pt 2):350-3. Review.PMID: 15787604 [PubMed - indexed for MEDLINE]Related articles

    20.

    Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes.

    Meyer MM, Levin K, Grimmsmann T, Perwitz N, Eirich A, Beck-Nielsen H, Klein HH.

    Diabetes. 2002 Sep;51(9):2691-7.PMID: 12196460 [PubMed - indexed for MEDLINE]Related articlesFree article

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