PubMed

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.

Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW.

Diabetes. 2002 Oct;51(10):2886-94. Erratum in: Diabetes 2003 Jan;52(1):223-4. PMID: 12351423 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo.

Iglesias MA, Furler SM, Cooney GJ, Kraegen EW, Ye JM.

Diabetes. 2004 Jul;53(7):1649-54.PMID: 15220186 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

Bergeron R, Previs SF, Cline GW, Perret P, Russell RR 3rd, Young LH, Shulman GI.

Diabetes. 2001 May;50(5):1076-82.PMID: 11334411 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome.

Buhl ES, Jessen N, Pold R, Ledet T, Flyvbjerg A, Pedersen SB, Pedersen O, Schmitz O, Lund S.

Diabetes. 2002 Jul;51(7):2199-206.PMID: 12086950 [PubMed - indexed for MEDLINE]Related articlesFree article

Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output.

Camacho RC, Pencek RR, Lacy DB, James FD, Donahue EP, Wasserman DH.

Diabetes. 2005 Feb;54(2):373-82.PMID: 15677495 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner.

Buhl ES, Jessen N, Schmitz O, Pedersen SB, Pedersen O, Holman GD, Lund S.

Diabetes. 2001 Jan;50(1):12-7.PMID: 11147776 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles.

Jessen N, Pold R, Buhl ES, Jensen LS, Schmitz O, Lund S.

J Appl Physiol. 2003 Apr;94(4):1373-9. Epub 2002 Dec 20.PMID: 12496137 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats.

Ye JM, Dzamko N, Hoy AJ, Iglesias MA, Kemp B, Kraegen E.

Diabetes. 2006 Oct;55(10):2797-804.PMID: 17003345 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated.

Winder WW, Holmes BF.

J Appl Physiol. 2000 Dec;89(6):2430-7.PMID: 11090599 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes.

Gaidhu MP, Fediuc S, Ceddia RB.

J Biol Chem. 2006 Sep 8;281(36):25956-64. Epub 2006 Jul 1.PMID: 16816404 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside.

Rivas DA, Yaspelkis BB 3rd, Hawley JA, Lessard SJ.

J Endocrinol. 2009 Sep;202(3):441-51. Epub 2009 Jul 2.PMID: 19574345 [PubMed - indexed for MEDLINE]Related articles

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin.

Camacho RC, Lacy DB, James FD, Donahue EP, Wasserman DH.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1039-43. Epub 2005 Jul 26.PMID: 16046457 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations.

Halseth AE, Ensor NJ, White TA, Ross SA, Gulve EA.

Biochem Biophys Res Commun. 2002 Jun 21;294(4):798-805.PMID: 12061777 [PubMed - indexed for MEDLINE]Related articles

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

Jørgensen SB, Viollet B, Andreelli F, Frøsig C, Birk JB, Schjerling P, Vaulont S, Richter EA, Wojtaszewski JF.

J Biol Chem. 2004 Jan 9;279(2):1070-9. Epub 2003 Oct 21.PMID: 14573616 [PubMed - indexed for MEDLINE]Related articlesFree article

A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat.

Oakes ND, Kennedy CJ, Jenkins AB, Laybutt DR, Chisholm DJ, Kraegen EW.

Diabetes. 1994 Oct;43(10):1203-10.PMID: 7926289 [PubMed - indexed for MEDLINE]Related articles

5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice.

Song XM, Fiedler M, Galuska D, Ryder JW, Fernström M, Chibalin AV, Wallberg-Henriksson H, Zierath JR.

Diabetologia. 2002 Jan;45(1):56-65.PMID: 11845224 [PubMed - indexed for MEDLINE]Related articles

Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats.

Yaspelkis BB 3rd, Davis JR, Saberi M, Smith TL, Jazayeri R, Singh M, Fernandez V, Trevino B, Chinookoswong N, Wang J, Shi ZQ, Levin N.

Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E130-42.PMID: 11120667 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.

Christopher M, Rantzau C, Chen ZP, Snow R, Kemp B, Alford FP.

Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1131-40. Epub 2006 Jun 13.PMID: 16772328 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle.

Olsen GS, Hansen BF.

Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E965-70.PMID: 12376323 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo.

Pencek RR, Shearer J, Camacho RC, James FD, Lacy DB, Fueger PT, Donahue EP, Snead W, Wasserman DH.

Diabetes. 2005 Feb;54(2):355-60.PMID: 15677492 [PubMed - indexed for MEDLINE]Related articlesFree article