PubMed

The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia.

Tschritter O, Stumvoll M, Machicao F, Holzwarth M, Weisser M, Maerker E, Teigeler A, Häring H, Fritsche A.

Diabetes. 2002 Sep;51(9):2854-60.PMID: 12196481 [PubMed - indexed for MEDLINE]Related articlesFree article

Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.

Nielsen LB, Ploug KB, Swift P, Ørskov C, Jansen-Olesen I, Chiarelli F, Holst JJ, Hougaard P, Pörksen S, Holl R, de Beaufort C, Gammeltoft S, Rorsman P, Mortensen HB, Hansen L; Hvidøre Study Group.

Eur J Endocrinol. 2007 Jun;156(6):663-71.PMID: 17535866 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose.

Greenbaum CJ, Prigeon RL, D'Alessio DA.

Diabetes. 2002 Apr;51(4):951-7.PMID: 11916912 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM.

Hansen L, Echwald SM, Hansen T, Urhammer SA, Clausen JO, Pedersen O.

Diabetes. 1997 Mar;46(3):508-12.PMID: 9032110 [PubMed - indexed for MEDLINE]Related articles

The prevalent Gly1057Asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion.

Fritsche A, Madaus A, Renn W, Tschritter O, Teigeler A, Weisser M, Maerker E, Machicao F, Häring H, Stumvoll M.

J Clin Endocrinol Metab. 2001 Oct;86(10):4822-5.PMID: 11600548 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans.

Quddusi S, Vahl TP, Hanson K, Prigeon RL, D'Alessio DA.

Diabetes Care. 2003 Mar;26(3):791-8.PMID: 12610039 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel hyperglycaemic clamp for characterization of islet function in humans: assessment of three different secretagogues, maximal insulin response and reproducibility.

Fritsche A, Stefan N, Hardt E, Schützenauer S, Häring H, Stumvoll M.

Eur J Clin Invest. 2000 May;30(5):411-8.PMID: 10809901 [PubMed - indexed for MEDLINE]Related articles

Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans.

Fritsche A, Madaus A, Stefan N, Tschritter O, Maerker E, Teigeler A, Häring H, Stumvoll M.

Diabetes. 2002 Feb;51 Suppl 1:S234-9.PMID: 11815485 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence against a rate-limiting role of proinsulin processing for maximal insulin secretion in subjects with impaired glucose tolerance and beta-cell dysfunction.

Stumvoll M, Fritsche A, Stefan N, Hardt E, Häring H.

J Clin Endocrinol Metab. 2001 Mar;86(3):1235-9.PMID: 11238514 [PubMed - indexed for MEDLINE]Related articlesFree article

One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.

Degn KB, Juhl CB, Sturis J, Jakobsen G, Brock B, Chandramouli V, Rungby J, Landau BR, Schmitz O.

Diabetes. 2004 May;53(5):1187-94.PMID: 15111485 [PubMed - indexed for MEDLINE]Related articlesFree article

Fasting hyperglycemia impairs glucose- but not insulin-mediated suppression of glucagon secretion.

Abdul-Ghani M, DeFronzo RA.

J Clin Endocrinol Metab. 2007 May;92(5):1778-84. Epub 2007 Feb 27.PMID: 17327375 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight.

Schou JH, Pilgaard K, Vilsbøll T, Jensen CB, Deacon CF, Holst JJ, Vølund A, Madsbad S, Vaag AA.

J Clin Endocrinol Metab. 2005 Aug;90(8):4912-9. Epub 2005 May 17.PMID: 15899957 [PubMed - indexed for MEDLINE]Related articlesFree article

Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.

't Hart LM, van Haeften TW, Dekker JM, Bot M, Heine RJ, Maassen JA.

Diabetes. 2002 Oct;51(10):3135-8.PMID: 12351459 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus.

Hansen T, Ambye L, Grarup N, Hansen L, Echwald SM, Ferrer J, Pedersen O.

Diabetologia. 2001 Oct;44(10):1330-4.PMID: 11692183 [PubMed - indexed for MEDLINE]Related articles

The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype.

Vilsbøll T, Knop FK, Krarup T, Johansen A, Madsbad S, Larsen S, Hansen T, Pedersen O, Holst JJ.

J Clin Endocrinol Metab. 2003 Oct;88(10):4897-903.PMID: 14557471 [PubMed - indexed for MEDLINE]Related articlesFree article

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion.

Schäfer SA, Müssig K, Staiger H, Machicao F, Stefan N, Gallwitz B, Häring HU, Fritsche A.

Diabetologia. 2009 Jun;52(6):1075-82. Epub 2009 Mar 28.PMID: 19330314 [PubMed - indexed for MEDLINE]Related articles

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

Schäfer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, 't Hart LM, Nijpels G, van Haeften TW, Häring HU, Fritsche A.

Diabetologia. 2007 Dec;50(12):2443-50. Epub 2007 Jul 28. Erratum in: Diabetologia. 2008 Jan;51(1):208. t' Hart, L M [corrected to 't Hart, L M]. Diabetologia. 2009 Mar;52(3):557. Dosage error in article text. PMID: 17661009 [PubMed - indexed for MEDLINE]Related articlesFree article

The Glu23Lys polymorphism in KCNJ11 and impaired hypoglycaemia awareness in patients with type 1 diabetes.

Holstein A, Plaschke A, Stumvoll M, Kovacs P.

J Hum Genet. 2005;50(10):530-3. Epub 2005 Sep 2.PMID: 16142506 [PubMed - indexed for MEDLINE]Related articles

Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans.

Stumvoll M, Fritsche A, Madaus A, Stefan N, Weisser M, Machicao F, Häring H.

Diabetes. 2001 Sep;50(9):2161-3.PMID: 11522685 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased fasting and oral glucose stimulated C-peptide in nondiabetic subjects with sequence variants in the sulfonylurea receptor 1 gene.

Weisnagel SJ, Rankinen T, Nadeau A, Rao DC, Chagnon YC, Pérusse L, Bouchard C.

Diabetes. 2001 Mar;50(3):697-702.PMID: 11246895 [PubMed - indexed for MEDLINE]Related articlesFree article