PubMed

Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition.

Patanè G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM.

Diabetes. 2002 Sep;51(9):2749-56.PMID: 12196468 [PubMed - indexed for MEDLINE]Related articlesFree article

PPAR-gamma overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein.

Ito E, Ozawa S, Takahashi K, Tanaka T, Katsuta H, Yamaguchi S, Maruyama M, Takizawa M, Katahira H, Yoshimoto K, Nagamatsu S, Ishida H.

Biochem Biophys Res Commun. 2004 Nov 12;324(2):810-4.PMID: 15474499 [PubMed - indexed for MEDLINE]Related articles

Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

Patanè G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F.

Diabetes. 2000 May;49(5):735-40.PMID: 10905481 [PubMed - indexed for MEDLINE]Related articlesFree article

Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets.

Tian JY, Li G, Gu YY, Zhang HL, Zhou WZ, Wang X, Zhu HD, Luo TH, Luo M.

Chin Med J (Engl). 2006 Apr 5;119(7):574-80.PMID: 16620699 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.

Sugden MC, Bulmer K, Augustine D, Holness MJ.

Diabetes. 2001 Dec;50(12):2729-36.PMID: 11723055 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion.

De Souza CT, Gasparetti AL, Pereira-da-Silva M, Araújo EP, Carvalheira JB, Saad MJ, Boschero AC, Carneiro EM, Velloso LA.

Diabetologia. 2003 Nov;46(11):1522-31. Epub 2003 Oct 24.PMID: 14576981 [PubMed - indexed for MEDLINE]Related articles

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB.

Diabetes. 2001 Jun;50(6):1302-10.PMID: 11375330 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2.

Suh YH, Kim SY, Lee HY, Jang BC, Bae JH, Sohn JN, Bae JH, Suh SI, Park JW, Lee KU, Song DK.

J Endocrinol. 2004 Oct;183(1):133-44.PMID: 15525581 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.

Wang MY, Shimabukuro M, Lee Y, Trinh KY, Chen JL, Newgard CB, Unger RH.

Diabetes. 1999 May;48(5):1020-5.PMID: 10331406 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F.

Diabetes. 2001 Apr;50(4):803-9.PMID: 11289045 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S.

Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E560-7. Epub 2003 Nov 18.PMID: 14625208 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c.

Yamashita T, Eto K, Okazaki Y, Yamashita S, Yamauchi T, Sekine N, Nagai R, Noda M, Kadowaki T.

Endocrinology. 2004 Aug;145(8):3566-77. Epub 2004 Apr 1.PMID: 15059954 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats.

Zhou YP, Ostenson CG, Ling ZC, Grill V.

Endocrinology. 1995 Aug;136(8):3546-51.PMID: 7628391 [PubMed - indexed for MEDLINE]Related articles

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

Effects of free fatty acids on beta-cell functions: a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox.

Yoshikawa H, Tajiri Y, Sako Y, Hashimoto T, Umeda F, Nawata H.

Metabolism. 2001 May;50(5):613-8.PMID: 11319727 [PubMed - indexed for MEDLINE]Related articles

Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell.

Roduit R, Morin J, Massé F, Segall L, Roche E, Newgard CB, Assimacopoulos-Jeannet F, Prentki M.

J Biol Chem. 2000 Nov 17;275(46):35799-806.PMID: 10967113 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply.

Li LX, Skorpen F, Egeberg K, Jørgensen IH, Grill V.

Endocrinology. 2002 Apr;143(4):1371-7.PMID: 11897694 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio.

Anello M, Ucciardello V, Piro S, Patané G, Frittitta L, Calabrese V, Giuffrida Stella AM, Vigneri R, Purrello F, Rabuazzo AM.

Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E1082-7.PMID: 11595666 [PubMed - indexed for MEDLINE]Related articlesFree article

A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.

Zhou YP, Berggren PO, Grill V.

Diabetes. 1996 May;45(5):580-6.PMID: 8621007 [PubMed - indexed for MEDLINE]Related articles