PubMed

Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study.

Pospisilik JA, Stafford SG, Demuth HU, McIntosh CH, Pederson RA.

Diabetes. 2002 Sep;51(9):2677-83.PMID: 12196458 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats.

Pospisilik JA, Stafford SG, Demuth HU, Brownsey R, Parkhouse W, Finegood DT, McIntosh CH, Pederson RA.

Diabetes. 2002 Apr;51(4):943-50.PMID: 11916911 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA.

Diabetes. 2003 Mar;52(3):741-50.PMID: 12606516 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats.

Sudre B, Broqua P, White RB, Ashworth D, Evans DM, Haigh R, Junien JL, Aubert ML.

Diabetes. 2002 May;51(5):1461-9.PMID: 11978643 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone.

Wargent E, Stocker C, Augstein P, Heinke P, Meyer A, Hoffmann T, Subramanian A, Sennitt MV, Demuth HU, Arch JR, Cawthorne MA.

Diabetes Obes Metab. 2005 Mar;7(2):170-81.PMID: 15715890 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats.

Hinke SA, Gelling RW, Pederson RA, Manhart S, Nian C, Demuth HU, McIntosh CH.

Diabetes. 2002 Mar;51(3):652-61.PMID: 11872663 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide.

Pederson RA, White HA, Schlenzig D, Pauly RP, McIntosh CH, Demuth HU.

Diabetes. 1998 Aug;47(8):1253-8.PMID: 9703325 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats.

Balkan B, Kwasnik L, Miserendino R, Holst JJ, Li X.

Diabetologia. 1999 Nov;42(11):1324-31.PMID: 10550416 [PubMed - indexed for MEDLINE]Related articles

Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.

Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA.

Diabetes. 2001 May;50(5):1004-11.PMID: 11334402 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance.

Augstein P, Berg S, Heinke P, Altmann S, Salzsieder E, Demuth HU, Freyse EJ.

Diabetes Obes Metab. 2008 Sep;10(10):850-61. Epub 2007 Oct 29.PMID: 17970756 [PubMed - indexed for MEDLINE]Related articles

NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat.

Carr RD, Brand CL, Bodvarsdottir TB, Hansen JB, Sturis J.

Diabetes. 2003 Oct;52(10):2513-8.PMID: 14514634 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice.

Irwin N, McClean PL, Flatt PR.

J Pept Sci. 2007 Jun;13(6):400-5.PMID: 17486662 [PubMed - indexed for MEDLINE]Related articles

Pulsatile intravenous insulin replacement in streptozotocin diabetic rats is more efficient than continuous delivery: effects on glycaemic control, insulin-mediated glucose metabolism and lipolysis.

Koopmans SJ, Sips HC, Krans HM, Radder JK.

Diabetologia. 1996 Apr;39(4):391-400.PMID: 8777988 [PubMed - indexed for MEDLINE]Related articles

Metformin causes reduction of food intake and body weight gain and improvement of glucose intolerance in combination with dipeptidyl peptidase IV inhibitor in Zucker fa/fa rats.

Yasuda N, Inoue T, Nagakura T, Yamazaki K, Kira K, Saeki T, Tanaka I.

J Pharmacol Exp Ther. 2004 Aug;310(2):614-9. Epub 2004 Mar 23.PMID: 15039452 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide.

Pauly RP, Demuth HU, Rosche F, Schmidt J, White HA, Lynn F, McIntosh CH, Pederson RA.

Metabolism. 1999 Mar;48(3):385-9.PMID: 10094118 [PubMed - indexed for MEDLINE]Related articles

Endothelin antagonism improves hepatic insulin sensitivity associated with insulin signaling in Zucker fatty rats.

Berthiaume N, Carlson CJ, Rondinone CM, Zinker BA.

Metabolism. 2005 Nov;54(11):1515-23.PMID: 16253642 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase IV inhibitors and diabetes therapy.

McIntosh CH.

Front Biosci. 2008 Jan 1;13:1753-73. Review.PMID: 17981665 [PubMed - indexed for MEDLINE]Related articles

Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo.

Someya Y, Tahara A, Nakano R, Matsuyama-Yokono A, Nagase I, Fukunaga Y, Takasu T, Hayakawa M, Shibasaki M.

Naunyn Schmiedebergs Arch Pharmacol. 2008 May;377(3):209-17. Epub 2008 Apr 9.PMID: 18398600 [PubMed - indexed for MEDLINE]Related articles

Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains.

Alberts P, Nilsson C, Selen G, Engblom LO, Edling NH, Norling S, Klingström G, Larsson C, Forsgren M, Ashkzari M, Nilsson CE, Fiedler M, Bergqvist E, Ohman B, Björkstrand E, Abrahmsen LB.

Endocrinology. 2003 Nov;144(11):4755-62. Epub 2003 Jul 31.PMID: 12960099 [PubMed - indexed for MEDLINE]Related articlesFree article

[New therapeutic approach in patients with type 2 diabetes based on glucagon-like peptide 1 (GLP-1) and gastric inhibitory peptide (GIP)]

Kluz J, Adamiec R.

Postepy Hig Med Dosw (Online). 2006;60:15-23. Review. Polish. PMID: 16407790 [PubMed - indexed for MEDLINE]Related articlesFree article