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Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease.

Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Iivonen S, Mannermaa A, Tuomilehto J, Nissinen A, Soininen H.

Ann Intern Med. 2002 Aug 6;137(3):149-55.PMID: 12160362 [PubMed - indexed for MEDLINE]Related articlesFree article

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.

Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A.

BMJ. 2001 Jun 16;322(7300):1447-51.PMID: 11408299 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging Study.

Irie F, Masaki KH, Petrovitch H, Abbott RD, Ross GW, Taaffe DR, Launer LJ, White LR.

Arch Gen Psychiatry. 2008 Aug;65(8):906-12.PMID: 18678795 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba.

Hall K, Murrell J, Ogunniyi A, Deeg M, Baiyewu O, Gao S, Gureje O, Dickens J, Evans R, Smith-Gamble V, Unverzagt FW, Shen J, Hendrie H.

Neurology. 2006 Jan 24;66(2):223-7.PMID: 16434658 [PubMed - indexed for MEDLINE]Related articles

Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study.

Solomon A, Kåreholt I, Ngandu T, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M.

Neurology. 2007 Mar 6;68(10):751-6.PMID: 17339582 [PubMed - indexed for MEDLINE]Related articles

Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.

Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kåreholt I, Winblad B, Helkala EL, Tuomilehto J, Soininen H, Nissinen A.

Arch Neurol. 2005 Oct;62(10):1556-60.PMID: 16216938 [PubMed - indexed for MEDLINE]Related articlesFree article

Incidence of dementia in relation to stroke and the apolipoprotein E epsilon4 allele in the very old. Findings from a population-based longitudinal study.

Zhu L, Fratiglioni L, Guo Z, Basun H, Corder EH, Winblad B, Viitanen M.

Stroke. 2000 Jan;31(1):53-60.PMID: 10625715 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction.

Bleumink GS, van Duijn CM, Kingma JH, Witteman JC, Hofman A, Stricker BH.

Am Heart J. 2004 Apr;147(4):685-9.PMID: 15077085 [PubMed - indexed for MEDLINE]Related articles

The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics.

Tang MX, Stern Y, Marder K, Bell K, Gurland B, Lantigua R, Andrews H, Feng L, Tycko B, Mayeux R.

JAMA. 1998 Mar 11;279(10):751-5.PMID: 9508150 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation.

Slooter AJ, Tang MX, van Duijn CM, Stern Y, Ott A, Bell K, Breteler MM, Van Broeckhoven C, Tatemichi TK, Tycko B, Hofman A, Mayeux R.

JAMA. 1997 Mar 12;277(10):818-21.PMID: 9052712 [PubMed - indexed for MEDLINE]Related articles

Joint effect of the APOE gene and midlife systolic blood pressure on late-life cognitive impairment: the Honolulu-Asia aging study.

Peila R, White LR, Petrovich H, Masaki K, Ross GW, Havlik RJ, Launer LJ.

Stroke. 2001 Dec 1;32(12):2882-9.PMID: 11739991 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein E epsilon4 allele and familial aggregation of Alzheimer disease.

Martinez M, Campion D, Brice A, Hannequin D, Dubois B, Didierjean O, Michon A, Thomas-Anterion C, Puel M, Frebourg T, Agid Y, Clerget-Darpoux F.

Arch Neurol. 1998 Jun;55(6):810-6.PMID: 9626772 [PubMed - indexed for MEDLINE]Related articlesFree article

The association between APOE and dementia does not seem to be mediated by vascular factors.

Prince M, Lovestone S, Cervilla J, Joels S, Powell J, Russ C, Mann A.

Neurology. 2000 Jan 25;54(2):397-402.PMID: 10668701 [PubMed - indexed for MEDLINE]Related articles

Genotypes with the apolipoprotein epsilon4 allele are predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men.

Stengård JH, Pekkanen J, Ehnholm C, Nissinen A, Sing CF.

Hum Genet. 1996 May;97(5):677-84.PMID: 8655152 [PubMed - indexed for MEDLINE]Related articles

Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study.

Laitinen MH, Ngandu T, Rovio S, Helkala EL, Uusitalo U, Viitanen M, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M.

Dement Geriatr Cogn Disord. 2006;22(1):99-107. Epub 2006 May 19.PMID: 16710090 [PubMed - indexed for MEDLINE]Related articles

Combined effects of APOE genotype, blood pressure, and antihypertensive drug use on incident AD.

Qiu C, Winblad B, Fastbom J, Fratiglioni L.

Neurology. 2003 Sep 9;61(5):655-60.PMID: 12963757 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein E and progression of chronic kidney disease.

Hsu CC, Kao WH, Coresh J, Pankow JS, Marsh-Manzi J, Boerwinkle E, Bray MS.

JAMA. 2005 Jun 15;293(23):2892-9.PMID: 15956634 [PubMed - indexed for MEDLINE]Related articlesFree article

Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study.

Slooter AJ, Cruts M, Kalmijn S, Hofman A, Breteler MM, Van Broeckhoven C, van Duijn CM.

Arch Neurol. 1998 Jul;55(7):964-8.PMID: 9678314 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease.

Tiraboschi P, Hansen LA, Masliah E, Alford M, Thal LJ, Corey-Bloom J.

Neurology. 2004 Jun 8;62(11):1977-83.PMID: 15184600 [PubMed - indexed for MEDLINE]Related articles

APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study.

Huang W, Qiu C, von Strauss E, Winblad B, Fratiglioni L.

Arch Neurol. 2004 Dec;61(12):1930-4. Erratum in: Arch Neurol. 2005 Mar;62(3):453. PMID: 15596614 [PubMed - indexed for MEDLINE]Related articlesFree article