PubMed

Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.

Alarcon C, Wicksteed B, Prentki M, Corkey BE, Rhodes CJ.

Diabetes. 2002 Aug;51(8):2496-504.PMID: 12145163 [PubMed - indexed for MEDLINE]Related articlesFree article

A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.

Skelly RH, Bollheimer LC, Wicksteed BL, Corkey BE, Rhodes CJ.

Biochem J. 1998 Apr 15;331 ( Pt 2):553-61.PMID: 9531497 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial regulation of insulin production in rat pancreatic islets.

Leibowitz G, Khaldi MZ, Shauer A, Parnes M, Oprescu AI, Cerasi E, Jonas JC, Kaiser N.

Diabetologia. 2005 Aug;48(8):1549-59. Epub 2005 Jun 29.PMID: 15986240 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin secretion and proinsulin biosynthesis by succinate.

Attali V, Parnes M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

Endocrinology. 2006 Nov;147(11):5110-8. Epub 2006 Aug 17.PMID: 16916949 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.

Skelly RH, Wicksteed B, Antinozzi PA, Rhodes CJ.

Diabetes. 2001 Aug;50(8):1791-8.PMID: 11473040 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.

Wicksteed B, Alarcon C, Briaud I, Lingohr MK, Rhodes CJ.

J Biol Chem. 2003 Oct 24;278(43):42080-90. Epub 2003 Aug 18.PMID: 12928442 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets.

MacDonald MJ, Fahien LA, Mertz RJ, Rana RS.

Arch Biochem Biophys. 1989 Mar;269(2):400-6.PMID: 2645827 [PubMed - indexed for MEDLINE]Related articles

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.

Bollheimer LC, Skelly RH, Chester MW, McGarry JD, Rhodes CJ.

J Clin Invest. 1998 Mar 1;101(5):1094-101.PMID: 9486980 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of aging on insulin synthesis and secretion. Differential effects on preproinsulin messenger RNA levels, proinsulin biosynthesis, and secretion of newly made and preformed insulin in the rat.

Wang SY, Halban PA, Rowe JW.

J Clin Invest. 1988 Jan;81(1):176-84.PMID: 3275693 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.

Alarcon C, Wicksteed B, Rhodes CJ.

Diabetologia. 2006 Dec;49(12):2920-9. Epub 2006 Oct 20.PMID: 17053883 [PubMed - indexed for MEDLINE]Related articles

Acute inhibition of proinsulin biosynthesis at the translational level by palmitic acid.

Katahira H, Nagamatsu S, Ozawa S, Nakamichi Y, Yamaguchi S, Furukawa H, Takizawa M, Yoshimoto K, Itagaki E, Ishida H.

Biochem Biophys Res Commun. 2001 Mar 30;282(2):507-10.PMID: 11401488 [PubMed - indexed for MEDLINE]Related articles

Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.

Skelly RH, Schuppin GT, Ishihara H, Oka Y, Rhodes CJ.

Diabetes. 1996 Jan;45(1):37-43.PMID: 8522057 [PubMed - indexed for MEDLINE]Related articles

Similar effects of succinic acid dimethyl ester and glucose on islet calcium oscillations and insulin release.

Mukala-Nsengu A, Fernández-Pascual S, Martín F, Martín-del-Río R, Tamarit-Rodriguez J.

Biochem Pharmacol. 2004 Mar 1;67(5):981-8.PMID: 15104252 [PubMed - indexed for MEDLINE]Related articles

Age-related impairment in the short term regulation of insulin biosynthesis by glucose in rat pancreatic islets.

Wang SY, Rowe JW.

Endocrinology. 1988 Aug;123(2):1008-13.PMID: 2456199 [PubMed - indexed for MEDLINE]Related articles

Activation of stimulus-secretion coupling in pancreatic beta-cells by specific products of glucose metabolism. Evidence for privileged signaling by glycolysis.

Mertz RJ, Worley JF, Spencer B, Johnson JH, Dukes ID.

J Biol Chem. 1996 Mar 1;271(9):4838-45.PMID: 8617753 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic signals produced by purine ribonucleosides stimulate proinsulin biosynthesis and insulin secretion.

Jain K, Logothetopoulos J.

Biochem J. 1978 Mar 15;170(3):461-7.PMID: 348199 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin biosynthesis in carp islets (Cyprinus carpio).

Huth A, Rapoport TA.

Acta Biol Med Ger. 1981;40(1):87-92.PMID: 7020309 [PubMed - indexed for MEDLINE]Related articles

Metabolic effects and fate of succinate esters in pancreatic islets.

Malaisse WJ, Sener A.

Am J Physiol. 1993 Mar;264(3 Pt 1):E434-40.PMID: 8460691 [PubMed - indexed for MEDLINE]Related articles

Lack of islet amyloid polypeptide regulation of insulin biosynthesis or secretion in normal rat islets.

Nagamatsu S, Carroll RJ, Grodsky GM, Steiner DF.

Diabetes. 1990 Jul;39(7):871-4.PMID: 2191889 [PubMed - indexed for MEDLINE]Related articles

Glucose regulated insulin biosynthesis in isolated rat pancreatic islets is accompanied by changes in proinsulin mRNA.

Giddings SJ, Chirgwin JM, Permutt MA.

Diabetes Res. 1985 Mar;2(2):71-5.PMID: 3899462 [PubMed - indexed for MEDLINE]Related articles