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    Results: 1 to 20 of 149

    1.

    The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.

    Hawley SA, Gadalla AE, Olsen GS, Hardie DG.

    Diabetes. 2002 Aug;51(8):2420-5.PMID: 12145153 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    AMP-activated protein kinase in metabolic control and insulin signaling.

    Towler MC, Hardie DG.

    Circ Res. 2007 Feb 16;100(3):328-41. Review.PMID: 17307971 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species.

    Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG 4th, Schlattner U, Neumann D, Brownlee M, Freeman MB, Goldman MH.

    J Biol Chem. 2004 Oct 15;279(42):43940-51. Epub 2004 Jul 19.PMID: 15265871 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

    Fryer LG, Parbu-Patel A, Carling D.

    J Biol Chem. 2002 Jul 12;277(28):25226-32. Epub 2002 May 6.PMID: 11994296 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.

    Woollhead AM, Sivagnanasundaram J, Kalsi KK, Pucovsky V, Pellatt LJ, Scott JW, Mustard KJ, Hardie DG, Baines DL.

    Br J Pharmacol. 2007 Aug;151(8):1204-15. Epub 2007 Jul 2.PMID: 17603555 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Role of AMP-activated protein kinase in mechanism of metformin action.

    Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE.

    J Clin Invest. 2001 Oct;108(8):1167-74.PMID: 11602624 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.

    Xie Z, Dong Y, Scholz R, Neumann D, Zou MH.

    Circulation. 2008 Feb 19;117(7):952-62. Epub 2008 Feb 4.PMID: 18250273 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase.

    Suter M, Riek U, Tuerk R, Schlattner U, Wallimann T, Neumann D.

    J Biol Chem. 2006 Oct 27;281(43):32207-16. Epub 2006 Aug 30.PMID: 16943194 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade.

    Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D.

    Biochem J. 2007 Apr 1;403(1):139-48.PMID: 17147517 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms.

    Saeedi R, Parsons HL, Wambolt RB, Paulson K, Sharma V, Dyck JR, Brownsey RW, Allard MF.

    Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2497-506. Epub 2008 Mar 28.PMID: 18375721 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside.

    Guigas B, Taleux N, Foretz M, Detaille D, Andreelli F, Viollet B, Hue L.

    Biochem J. 2007 Jun 15;404(3):499-507.PMID: 17324122 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.

    Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG.

    J Biol. 2003;2(4):28. Epub 2003 Sep 24.PMID: 14511394 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta.

    Stahmann N, Woods A, Carling D, Heller R.

    Mol Cell Biol. 2006 Aug;26(16):5933-45.PMID: 16880506 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP-activated protein kinase activity in the perfused mouse heart.

    Zhang L, Frederich M, He H, Balschi JA.

    Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1235-43. Epub 2005 Oct 28.PMID: 16258030 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

    Salt IP, Johnson G, Ashcroft SJ, Hardie DG.

    Biochem J. 1998 Nov 1;335 ( Pt 3):533-9.PMID: 9794792 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.

    Chan AY, Soltys CL, Young ME, Proud CG, Dyck JR.

    J Biol Chem. 2004 Jul 30;279(31):32771-9. Epub 2004 May 24.PMID: 15159410 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.

    Hattori Y, Suzuki K, Hattori S, Kasai K.

    Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.PMID: 16636195 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes.

    Shen QW, Zhu MJ, Tong J, Ren J, Du M.

    Am J Physiol Cell Physiol. 2007 Oct;293(4):C1395-403. Epub 2007 Aug 8.PMID: 17687000 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.

    Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA.

    J Biol Chem. 2004 Nov 12;279(46):47898-905. Epub 2004 Sep 14.PMID: 15371448 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    [Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases]

    Foretz M, Taleux N, Guigas B, Horman S, Beauloye C, Andreelli F, Bertrand L, Viollet B.

    Med Sci (Paris). 2006 Apr;22(4):381-8. Review. French. PMID: 16597407 [PubMed - indexed for MEDLINE]Related articles

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