PubMed

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

Rondinone CM, Trevillyan JM, Clampit J, Gum RJ, Berg C, Kroeger P, Frost L, Zinker BA, Reilly R, Ulrich R, Butler M, Monia BP, Jirousek MR, Waring JF.

Diabetes. 2002 Aug;51(8):2405-11.PMID: 12145151 [PubMed - indexed for MEDLINE]Related articlesFree article

PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.

Waring JF, Ciurlionis R, Clampit JE, Morgan S, Gum RJ, Jolly RA, Kroeger P, Frost L, Trevillyan J, Zinker BA, Jirousek M, Ulrich RG, Rondinone CM.

Mol Cell Endocrinol. 2003 May 30;203(1-2):155-68.PMID: 12782412 [PubMed - indexed for MEDLINE]Related articles

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.

Zinker BA, Rondinone CM, Trevillyan JM, Gum RJ, Clampit JE, Waring JF, Xie N, Wilcox D, Jacobson P, Frost L, Kroeger PE, Reilly RM, Koterski S, Opgenorth TJ, Ulrich RG, Crosby S, Butler M, Murray SF, McKay RA, Bhanot S, Monia BP, Jirousek MR.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11357-62. Epub 2002 Aug 8.PMID: 12169659 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.

Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, Trevillyan JM, Ulrich RG, Jirousek MR, Rondinone CM.

Diabetes. 2003 Jan;52(1):21-8.PMID: 12502489 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM.

Endocrinology. 2007 Feb;148(2):594-608. Epub 2006 Oct 26.PMID: 17068137 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells.

Clampit JE, Meuth JL, Smith HT, Reilly RM, Jirousek MR, Trevillyan JM, Rondinone CM.

Biochem Biophys Res Commun. 2003 Jan 10;300(2):261-7.PMID: 12504077 [PubMed - indexed for MEDLINE]Related articles

Reduction of PTP1B induces differential expression of PI3-kinase (p85alpha) isoforms.

Rondinone CM, Clampit J, Gum RJ, Zinker BA, Jirousek MR, Trevillyan JM.

Biochem Biophys Res Commun. 2004 Oct 15;323(2):652-9.PMID: 15369800 [PubMed - indexed for MEDLINE]Related articles

Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice.

Pandey SK, Yu XX, Watts LM, Michael MD, Sloop KW, Rivard AR, Leedom TA, Manchem VP, Samadzadeh L, McKay RA, Monia BP, Bhanot S.

J Biol Chem. 2007 May 11;282(19):14291-9. Epub 2007 Mar 12.PMID: 17353188 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression.

Shimizu S, Ugi S, Maegawa H, Egawa K, Nishio Y, Yoshizaki T, Shi K, Nagai Y, Morino K, Nemoto K, Nakamura T, Bryer-Ash M, Kashiwagi A.

J Biol Chem. 2003 Oct 31;278(44):43095-101. Epub 2003 Aug 26.PMID: 12941932 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes.

Shimizu S, Maegawa H, Egawa K, Shi K, Bryer-Ash M, Kashiwagi A.

Endocrinology. 2002 Dec;143(12):4563-9.PMID: 12446583 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.

Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK.

Diabetes. 2009 Mar;58(3):590-9. Epub 2008 Dec 15.PMID: 19074988 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

Valverde AM, Kahn CR, Benito M.

Diabetes. 1999 Nov;48(11):2122-31.PMID: 10535444 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.

Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, Kahn BB.

J Biol Chem. 2004 Jun 4;279(23):24844-51. Epub 2004 Mar 18.PMID: 15031294 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.

Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF.

Diabetes. 2004 Jan;53(1):61-6.PMID: 14693698 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation.

Mur C, Arribas M, Benito M, Valverde AM.

Endocrinology. 2003 Feb;144(2):581-93.PMID: 12538620 [PubMed - indexed for MEDLINE]Related articlesFree article

Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.

Gum RJ, Gaede LL, Heindel MA, Waring JF, Trevillyan JM, Zinker BA, Stark ME, Wilcox D, Jirousek MR, Rondinone CM, Ulrich RG.

Mol Endocrinol. 2003 Jun;17(6):1131-43. Epub 2003 Mar 20.PMID: 12649327 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.

Haj FG, Zabolotny JM, Kim YB, Kahn BB, Neel BG.

J Biol Chem. 2005 Apr 15;280(15):15038-46. Epub 2005 Feb 7.PMID: 15699041 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular effects of small molecule PTP1B inhibitors on insulin signaling.

Xie L, Lee SY, Andersen JN, Waters S, Shen K, Guo XL, Moller NP, Olefsky JM, Lawrence DS, Zhang ZY.

Biochemistry. 2003 Nov 11;42(44):12792-804.PMID: 14596593 [PubMed - indexed for MEDLINE]Related articles

Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.

Arribas M, Valverde AM, Benito M.

J Biol Chem. 2003 Nov 14;278(46):45189-99. Epub 2003 Aug 27.PMID: 12944402 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance.

Goldstein BJ.

Curr Drug Targets Immune Endocr Metabol Disord. 2001 Nov;1(3):265-75. Review.PMID: 12477292 [PubMed - indexed for MEDLINE]Related articles