PubMed

Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity.

Huang C, Somwar R, Patel N, Niu W, Török D, Klip A.

Diabetes. 2002 Jul;51(7):2090-8.PMID: 12086937 [PubMed - indexed for MEDLINE]Related articlesFree article

GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase.

Somwar R, Kim DY, Sweeney G, Huang C, Niu W, Lador C, Ramlal T, Klip A.

Biochem J. 2001 Nov 1;359(Pt 3):639-49.PMID: 11672439 [PubMed - indexed for MEDLINE]Related articlesFree article

The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.

Konrad D, Somwar R, Sweeney G, Yaworsky K, Hayashi M, Ramlal T, Klip A.

Diabetes. 2001 Jun;50(6):1464-71.PMID: 11375349 [PubMed - indexed for MEDLINE]Related articlesFree article

An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes.

Sweeney G, Somwar R, Ramlal T, Volchuk A, Ueyama A, Klip A.

J Biol Chem. 1999 Apr 9;274(15):10071-8.PMID: 10187787 [PubMed - indexed for MEDLINE]Related articlesFree article

Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis.

Niu W, Huang C, Nawaz Z, Levy M, Somwar R, Li D, Bilan PJ, Klip A.

J Biol Chem. 2003 May 16;278(20):17953-62. Epub 2003 Mar 11.PMID: 12637564 [PubMed - indexed for MEDLINE]Related articlesFree article

High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in l6 rat skeletal muscle cells.

Sweeney G, Keen J, Somwar R, Konrad D, Garg R, Klip A.

Endocrinology. 2001 Nov;142(11):4806-12.PMID: 11606447 [PubMed - indexed for MEDLINE]Related articlesFree article

A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation.

Somwar R, Koterski S, Sweeney G, Sciotti R, Djuric S, Berg C, Trevillyan J, Scherer PE, Rondinone CM, Klip A.

J Biol Chem. 2002 Dec 27;277(52):50386-95. Epub 2002 Oct 21.PMID: 12393894 [PubMed - indexed for MEDLINE]Related articlesFree article

Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity.

Bazuine M, Ouwens DM, Gomes de Mesquita DS, Maassen JA.

Eur J Biochem. 2003 Oct;270(19):3891-903.PMID: 14511371 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport.

Somwar R, Niu W, Kim DY, Sweeney G, Randhawa VK, Huang C, Ramlal T, Klip A.

J Biol Chem. 2001 Dec 7;276(49):46079-87. Epub 2001 Oct 11.PMID: 11598141 [PubMed - indexed for MEDLINE]Related articlesFree article

MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression.

Fujishiro M, Gotoh Y, Katagiri H, Sakoda H, Ogihara T, Anai M, Onishi Y, Ono H, Funaki M, Inukai K, Fukushima Y, Kikuchi M, Oka Y, Asano T.

J Biol Chem. 2001 Jun 8;276(23):19800-6. Epub 2001 Feb 27.PMID: 11279172 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone induces GLUT4 translocation in L6 myotubes.

Yonemitsu S, Nishimura H, Shintani M, Inoue R, Yamamoto Y, Masuzaki H, Ogawa Y, Hosoda K, Inoue G, Hayashi T, Nakao K.

Diabetes. 2001 May;50(5):1093-101.PMID: 11334413 [PubMed - indexed for MEDLINE]Related articlesFree article

Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice.

Konrad D, Bilan PJ, Nawaz Z, Sweeney G, Niu W, Liu Z, Antonescu CN, Rudich A, Klip A.

Diabetes. 2002 Sep;51(9):2719-26.PMID: 12196464 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute and chronic leptin treatment mediate contrasting effects on signaling, glucose uptake, and GLUT4 translocation in L6-GLUT4myc myotubes.

Tajmir P, Kwan JJ, Kessas M, Mozammel S, Sweeney G.

J Cell Physiol. 2003 Oct;197(1):122-30.PMID: 12942548 [PubMed - indexed for MEDLINE]Related articles

Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation.

Moon B, Kwan JJ, Duddy N, Sweeney G, Begum N.

Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E106-15. Epub 2003 Mar 4.PMID: 12618360 [PubMed - indexed for MEDLINE]Related articlesFree article

MEK inhibitors impair insulin-stimulated glucose uptake in 3T3-L1 adipocytes.

Harmon AW, Paul DS, Patel YM.

Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E758-66. Epub 2004 Jun 1.PMID: 15172888 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity.

Antonescu CN, Huang C, Niu W, Liu Z, Eyers PA, Heidenreich KA, Bilan PJ, Klip A.

Endocrinology. 2005 Sep;146(9):3773-81. Epub 2005 Jun 9.PMID: 15947002 [PubMed - indexed for MEDLINE]Related articlesFree article

The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle.

Lemieux K, Konrad D, Klip A, Marette A.

FASEB J. 2003 Sep;17(12):1658-65.PMID: 12958172 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of wild-type Akt1 promoted insulin-stimulated p70S6 kinase (p70S6K) activity and affected GSK3 beta regulation, but did not promote insulin-stimulated GLUT4 translocation or glucose transport in L6 myotubes.

Noda S, Kishi K, Yuasa T, Hayashi H, Ohnishi T, Miyata I, Nishitani H, Ebina Y.

J Med Invest. 2000 Feb;47(1-2):47-55.PMID: 10740979 [PubMed - indexed for MEDLINE]Related articles

Regulation of glucose transporters by insulin and extracellular glucose in C2C12 myotubes.

Nedachi T, Kanzaki M.

Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E817-28. Epub 2006 May 30.PMID: 16735448 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner.

de Alvaro C, Teruel T, Hernandez R, Lorenzo M.

J Biol Chem. 2004 Apr 23;279(17):17070-8. Epub 2004 Feb 4.PMID: 14764603 [PubMed - indexed for MEDLINE]Related articlesFree article