PubMed

Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.

Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, Zhou G, Williamson JM, Ljunqvist O, Efendic S, Moller DE, Thorell A, Goodyear LJ.

Diabetes. 2002 Jul;51(7):2074-81.PMID: 12086935 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.

Luna V, Casauban L, Sajan MP, Gomez-Daspet J, Powe JL, Miura A, Rivas J, Standaert ML, Farese RV.

Diabetologia. 2006 Feb;49(2):375-82. Epub 2006 Jan 5.PMID: 16395615 [PubMed - indexed for MEDLINE]Related articles

Role of AMP-activated protein kinase in mechanism of metformin action.

Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE.

J Clin Invest. 2001 Oct;108(8):1167-74.PMID: 11602624 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise.

Musi N, Fujii N, Hirshman MF, Ekberg I, Fröberg S, Ljungqvist O, Thorell A, Goodyear LJ.

Diabetes. 2001 May;50(5):921-7.PMID: 11334434 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.

Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA.

J Biol Chem. 2004 Nov 12;279(46):47898-905. Epub 2004 Sep 14.PMID: 15371448 [PubMed - indexed for MEDLINE]Related articlesFree article

Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity.

Doi M, Yamaoka I, Nakayama M, Mochizuki S, Sugahara K, Yoshizawa F.

J Nutr. 2005 Sep;135(9):2103-8.PMID: 16140883 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase and type 2 diabetes.

Musi N.

Curr Med Chem. 2006;13(5):583-9. Review.PMID: 16515522 [PubMed - indexed for MEDLINE]Related articles

Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes.

Musi N, Goodyear LJ.

Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul;2(2):119-27. Review.PMID: 12476786 [PubMed - indexed for MEDLINE]Related articles

Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase.

Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB.

Diabetes. 2003 Jul;52(7):1635-40.PMID: 12829626 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA.

Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. Epub 2004 Feb 10.PMID: 14871885 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes.

Gaidhu MP, Fediuc S, Ceddia RB.

J Biol Chem. 2006 Sep 8;281(36):25956-64. Epub 2006 Jul 1.PMID: 16816404 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase and muscle glucose uptake.

Musi N, Goodyear LJ.

Acta Physiol Scand. 2003 Aug;178(4):337-45. Review.PMID: 12864738 [PubMed - indexed for MEDLINE]Related articles

AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes.

Højlund K, Mustard KJ, Staehr P, Hardie DG, Beck-Nielsen H, Richter EA, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2004 Feb;286(2):E239-44. Epub 2003 Oct 7.PMID: 14532170 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of 5'AMP-activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease.

Nielsen JN, Wojtaszewski JF, Haller RG, Hardie DG, Kemp BE, Richter EA, Vissing J.

J Physiol. 2002 Jun 15;541(Pt 3):979-89.PMID: 12068056 [PubMed - indexed for MEDLINE]Related articlesFree article

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

Sakamoto K, Göransson O, Hardie DG, Alessi DR.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E310-7. Epub 2004 Apr 6.PMID: 15068958 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-intensity contraction activates the alpha1-isoform of 5'-AMP-activated protein kinase in rat skeletal muscle.

Toyoda T, Tanaka S, Ebihara K, Masuzaki H, Hosoda K, Sato K, Fushiki T, Nakao K, Hayashi T.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E583-90. Epub 2005 Oct 25.PMID: 16249251 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral glucose ingestion attenuates exercise-induced activation of 5'-AMP-activated protein kinase in human skeletal muscle.

Akerstrom TC, Birk JB, Klein DK, Erikstrup C, Plomgaard P, Pedersen BK, Wojtaszewski J.

Biochem Biophys Res Commun. 2006 Apr 14;342(3):949-55.PMID: 16598851 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase: Role in metabolism and therapeutic implications.

Schimmack G, Defronzo RA, Musi N.

Diabetes Obes Metab. 2006 Nov;8(6):591-602. Review.PMID: 17026483 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance and improvements in signal transduction.

Musi N, Goodyear LJ.

Endocrine. 2006 Feb;29(1):73-80. Review.PMID: 16622294 [PubMed - indexed for MEDLINE]Related articles

Effect of AICAR treatment on glycogen metabolism in skeletal muscle.

Aschenbach WG, Hirshman MF, Fujii N, Sakamoto K, Howlett KF, Goodyear LJ.

Diabetes. 2002 Mar;51(3):567-73.PMID: 11872652 [PubMed - indexed for MEDLINE]Related articlesFree article