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    Results: 1 to 20 of 110

    1.

    The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.

    Marion E, Kaisaki PJ, Pouillon V, Gueydan C, Levy JC, Bodson A, Krzentowski G, Daubresse JC, Mockel J, Behrends J, Servais G, Szpirer C, Kruys V, Gauguier D, Schurmans S.

    Diabetes. 2002 Jul;51(7):2012-7.PMID: 12086927 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.

    Kaisaki PJ, Delépine M, Woon PY, Sebag-Montefiore L, Wilder SP, Menzel S, Vionnet N, Marion E, Riveline JP, Charpentier G, Schurmans S, Levy JC, Lathrop M, Farrall M, Gauguier D.

    Diabetes. 2004 Jul;53(7):1900-4.PMID: 15220217 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2.

    Dyson JM, Kong AM, Wiradjaja F, Astle MV, Gurung R, Mitchell CA.

    Int J Biochem Cell Biol. 2005 Nov;37(11):2260-5. Review.PMID: 15964236 [PubMed - indexed for MEDLINE]Related articles

    4.

    Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors.

    Ishihara H, Sasaoka T, Ishiki M, Wada T, Hori H, Kagawa S, Kobayashi M.

    Mol Endocrinol. 2002 Oct;16(10):2371-81.PMID: 12351701 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity.

    Sasaoka T, Wada T, Tsuneki H.

    Pharmacol Ther. 2006 Dec;112(3):799-809. Epub 2006 Jul 13. Review.PMID: 16842857 [PubMed - indexed for MEDLINE]Related articles

    6.

    Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.

    Kagawa S, Sasaoka T, Yaguchi S, Ishihara H, Tsuneki H, Murakami S, Fukui K, Wada T, Kobayashi S, Kimura I, Kobayashi M.

    J Clin Endocrinol Metab. 2005 May;90(5):2911-9. Epub 2005 Feb 1.PMID: 15687335 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population.

    Ishihara H, Sasaoka T, Kagawa S, Murakami S, Fukui K, Kawagishi Y, Yamazaki K, Sato A, Iwata M, Urakaze M, Ishiki M, Wada T, Yaguchi S, Tsuneki H, Kimura I, Kobayashi M.

    FEBS Lett. 2003 Nov 20;554(3):450-4.PMID: 14623110 [PubMed - indexed for MEDLINE]Related articles

    8.

    The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners.

    Onnockx S, De Schutter J, Blockmans M, Xie J, Jacobs C, Vanderwinden JM, Erneux C, Pirson I.

    J Cell Physiol. 2008 Jan;214(1):260-72.PMID: 17620296 [PubMed - indexed for MEDLINE]Related articles

    9.

    The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse.

    Schurmans S, Carrió R, Behrends J, Pouillon V, Merino J, Clément S.

    Genomics. 1999 Dec 1;62(2):260-71.PMID: 10610720 [PubMed - indexed for MEDLINE]Related articles

    10.

    Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes.

    Abdel-Halim SM, Guenifi A, He B, Yang B, Mustafa M, Höjeberg B, Hillert J, Bakhiet M, Efendić S.

    Diabetes. 1998 Mar;47(3):498-504.PMID: 9519762 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.

    Sasaoka T, Kikuchi K, Wada T, Sato A, Hori H, Murakami S, Fukui K, Ishihara H, Aota R, Kimura I, Kobayashi M.

    Endocrinology. 2003 Sep;144(9):4204-14.PMID: 12933696 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Association of SH-2 containing inositol 5'-phosphatase 2 gene polymorphisms and hyperglycemia.

    Ishida S, Funakoshi A, Miyasaka K, Shimokata H, Ando F, Takiguchi S.

    Pancreas. 2006 Jul;33(1):63-7.PMID: 16804414 [PubMed - indexed for MEDLINE]Related articles

    13.

    Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.

    Wallis RH, Wallace KJ, Collins SC, McAteer M, Argoud K, Bihoreau MT, Kaisaki PJ, Gauguier D.

    Diabetologia. 2004 Jun;47(6):1096-106. Epub 2004 May 26.PMID: 15164172 [PubMed - indexed for MEDLINE]Related articles

    14.

    The lipid phosphatase SHIP2 controls insulin sensitivity.

    Clément S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S.

    Nature. 2001 Jan 4;409(6816):92-7. Erratum in: Nature. 2004 Oct 14;431(7010):878. PMID: 11343120 [PubMed - indexed for MEDLINE]Related articles

    15.

    Impact of Src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids.

    Murakami S, Sasaoka T, Wada T, Fukui K, Nagira K, Ishihara H, Usui I, Kobayashi M.

    Endocrinology. 2004 Jul;145(7):3215-23. Epub 2004 Mar 24.PMID: 15044364 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.

    Sleeman MW, Wortley KE, Lai KM, Gowen LC, Kintner J, Kline WO, Garcia K, Stitt TN, Yancopoulos GD, Wiegand SJ, Glass DJ.

    Nat Med. 2005 Feb;11(2):199-205. Epub 2005 Jan 16. Erratum in: Nat Med. 2005 Mar;11(3):353. PMID: 15654325 [PubMed - indexed for MEDLINE]Related articles

    17.

    SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling.

    Wang Y, Keogh RJ, Hunter MG, Mitchell CA, Frey RS, Javaid K, Malik AB, Schurmans S, Tridandapani S, Marsh CB.

    J Immunol. 2004 Dec 1;173(11):6820-30.PMID: 15557176 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism, gluconeogenesis, and glycolysis.

    Grempler R, Zibrova D, Schoelch C, van Marle A, Rippmann JF, Redemann N.

    Diabetes. 2007 Sep;56(9):2235-41. Epub 2007 Jun 27.PMID: 17596404 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice.

    Fukui K, Wada T, Kagawa S, Nagira K, Ikubo M, Ishihara H, Kobayashi M, Sasaoka T.

    Diabetes. 2005 Jul;54(7):1958-67.PMID: 15983195 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Transcriptional profiling of C2C12 myotubes in response to SHIP2 depletion and insulin stimulation.

    Huard C, Martinez RV, Ross C, Johnson JW, Zhong W, Hill AA, Kim R, Paulsen JE, Shih HH.

    Genomics. 2007 Feb;89(2):270-9. Epub 2006 Nov 21.PMID: 17123777 [PubMed - indexed for MEDLINE]Related articles

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