PubMed

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha.

Itani SI, Ruderman NB, Schmieder F, Boden G.

Diabetes. 2002 Jul;51(7):2005-11.PMID: 12086926 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin, skeletal muscle lipids, and lipid-induced insulin resistance.

Dube JJ, Bhatt BA, Dedousis N, Bonen A, O'Doherty RM.

Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R642-50. Epub 2007 May 9.PMID: 17491114 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI.

Diabetes. 1999 Jun;48(6):1270-4.PMID: 10342815 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training.

Sriwijitkamol A, Christ-Roberts C, Berria R, Eagan P, Pratipanawatr T, DeFronzo RA, Mandarino LJ, Musi N.

Diabetes. 2006 Mar;55(3):760-7.PMID: 16505240 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver.

Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, Reddy P, Xiang X, Luo Z, Ruderman N.

Diabetes. 2005 Dec;54(12):3458-65.PMID: 16306362 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta.

Lam TK, Yoshii H, Haber CA, Bogdanovic E, Lam L, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E682-91.PMID: 12217885 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.

Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E471-9. Epub 2005 Oct 18.PMID: 16234268 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.

Itani SI, Zhou Q, Pories WJ, MacDonald KG, Dohm GL.

Diabetes. 2000 Aug;49(8):1353-8.PMID: 10923637 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of gender on lipid-induced insulin resistance in obese subjects.

Vistisen B, Hellgren LI, Vadset T, Scheede-Bergdahl C, Helge JW, Dela F, Stallknecht B.

Eur J Endocrinol. 2008 Jan;158(1):61-8.PMID: 18166818 [PubMed - indexed for MEDLINE]Related articlesFree article

PKC-theta knockout mice are protected from fat-induced insulin resistance.

Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline GW, O'Brien WR, Littman DR, Shulman GI.

J Clin Invest. 2004 Sep;114(6):823-7.PMID: 15372106 [PubMed - indexed for MEDLINE]Related articlesFree article

Dose-response effect of elevated plasma free fatty acid on insulin signaling.

Belfort R, Mandarino L, Kashyap S, Wirfel K, Pratipanawatr T, Berria R, Defronzo RA, Cusi K.

Diabetes. 2005 Jun;54(6):1640-8.PMID: 15919784 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation.

Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky JM.

J Clin Endocrinol Metab. 2002 Jan;87(1):226-34.PMID: 11788651 [PubMed - indexed for MEDLINE]Related articlesFree article

High-fat- and lipid-induced insulin resistance in rats: the comparison of glucose metabolism, plasma resistin and adiponectin levels.

Li L, Yang G, Li Q, Tang Y, Li K.

Ann Nutr Metab. 2006;50(6):499-505. Epub 2006 Dec 21.PMID: 17191023 [PubMed - indexed for MEDLINE]Related articles

Evidence against a role for insulin-signaling proteins PI 3-kinase and Akt in insulin resistance in human skeletal muscle induced by short-term GH infusion.

Jessen N, Djurhuus CB, Jørgensen JO, Jensen LS, Møller N, Lund S, Schmitz O.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E194-9. Epub 2004 Aug 31.PMID: 15339744 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).

Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ.

J Mol Endocrinol. 2003 Jun;30(3):271-86.PMID: 12790799 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance.

Heydrick SJ, Ruderman NB, Kurowski TG, Adams HB, Chen KS.

Diabetes. 1991 Dec;40(12):1707-11.PMID: 1756911 [PubMed - indexed for MEDLINE]Related articles

Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistance.

Polkinghorne E, Lau Q, Cooney GJ, Kraegen EW, Cleasby ME.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E316-25. Epub 2007 Nov 20.PMID: 18029440 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects.

Reyna SM, Ghosh S, Tantiwong P, Meka CS, Eagan P, Jenkinson CP, Cersosimo E, Defronzo RA, Coletta DK, Sriwijitkamol A, Musi N.

Diabetes. 2008 Oct;57(10):2595-602. Epub 2008 Jul 15.PMID: 18633101 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.

Storgaard H, Jensen CB, Björnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA.

J Clin Endocrinol Metab. 2004 Mar;89(3):1301-11.PMID: 15001626 [PubMed - indexed for MEDLINE]Related articlesFree article

Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver.

Ye JM, Frangioudakis G, Iglesias MA, Furler SM, Ellis B, Dzamko N, Cooney GJ, Kraegen EW.

Endocrinology. 2002 Dec;143(12):4527-35.PMID: 12446579 [PubMed - indexed for MEDLINE]Related articlesFree article