PubMed

The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.

Hornum L, Rømer J, Markholst H.

Diabetes. 2002 Jun;51(6):1972-9.PMID: 12031988 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequence variation and expression of the Gimap gene family in the BB rat.

Rutledge EA, Fuller JM, Van Yserloo B, Moralejo DH, Ettinger RA, Gaur P, Hoehna JL, Peterson MR, Jensen R, Kwitek AE, Lernmark A.

Exp Diabetes Res. 2009;2009:835650. Epub 2009 May 3.PMID: 19421422 [PubMed - indexed for MEDLINE]Related articlesFree article

Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.

MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES, Lernmark A.

Genome Res. 2002 Jul;12(7):1029-39.PMID: 12097339 [PubMed - indexed for MEDLINE]Related articlesFree article

Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.

Payne F, Smyth DJ, Pask R, Barratt BJ, Cooper JD, Twells RC, Walker NM, Lam AC, Smink LJ, Nutland S, Rance HE, Todd JA.

Diabetes. 2004 Feb;53(2):505-9.PMID: 14747305 [PubMed - indexed for MEDLINE]Related articlesFree article

hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies.

Zenz T, Roessner A, Thomas A, Fröhling S, Döhner H, Calabretta B, Dahéron L.

Genes Immun. 2004 Mar;5(2):109-16.PMID: 14724691 [PubMed - indexed for MEDLINE]Related articles

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.

Martin AM, Maxson MN, Leif J, Mordes JP, Greiner DL, Blankenhorn EP.

Diabetes. 1999 Nov;48(11):2138-44.PMID: 10535446 [PubMed - indexed for MEDLINE]Related articlesFree article

A sequence-ready PAC contig of a 550-kb region on rat chromosome 4 including the diabetes susceptibility gene Lyp.

Hornum L, Markholst H.

Genomics. 2000 Nov 1;69(3):305-13.PMID: 11056048 [PubMed - indexed for MEDLINE]Related articles

Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.

Martin AM, Blankenhorn EP, Maxson MN, Zhao M, Leif J, Mordes JP, Greiner DL.

Diabetes. 1999 Jan;48(1):50-8.PMID: 9892222 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity.

Dahéron L, Zenz T, Siracusa LD, Brenner C, Calabretta B.

Nucleic Acids Res. 2001 Mar 15;29(6):1308-16.PMID: 11238997 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative mapping of the human homologue of the rat diabetes susceptibility gene lyp to a 1.3-Mb segment on HSA7.

Hornum L, Markholst H.

Genomics. 2000 Apr 1;65(1):81-3.PMID: 10777670 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in the multifunctional transcription factor Yy1 and type 1 diabetes mellitus in the BB rat.

Klöting N, Klöting I.

Mol Genet Metab. 2004 Jul;82(3):255-9.PMID: 15234341 [PubMed - indexed for MEDLINE]Related articles

Excessive production of nitric oxide by macrophages from DP-BB rats is secondary to the T-lymphopenic state of these animals.

Lau A, Ramanathan S, Poussier P.

Diabetes. 1998 Feb;47(2):197-205.PMID: 9519713 [PubMed - indexed for MEDLINE]Related articles

Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.

Sommandas V, Rutledge EA, Van Yserloo B, Fuller J, Lernmark A, Drexhage HA.

J Autoimmun. 2005 Aug;25(1):46-56.PMID: 15922563 [PubMed - indexed for MEDLINE]Related articles

Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.

Hessner MJ, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, Lernmark A, Ghosh S.

J Immunol. 2004 Dec 1;173(11):6993-7002.PMID: 15557196 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping of caspase-2 in the rat and its exclusion as a candidate gene for lymphopenia.

Hornum L, Rasmussen SB, Markholst H.

Mamm Genome. 1999 Mar;10(3):244-8.PMID: 10051319 [PubMed - indexed for MEDLINE]Related articles

DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats.

Hawkins T, Fuller J, Olson K, Speros S, Lernmark A.

J Autoimmun. 2005 Dec;25(4):251-7. Epub 2005 Oct 24.PMID: 16246525 [PubMed - indexed for MEDLINE]Related articles

T-cell survival regulator LKLF is not involved in inappropriate apoptosis of diabetes-prone BBDP rat T cells.

Diessenbacher P, Bartels K, Koch-Nolte F, Haag F.

Ann N Y Acad Sci. 2003 Dec;1010:548-51.PMID: 15033788 [PubMed - indexed for MEDLINE]Related articles

Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat.

Geoffrey R, Jia S, Kwitek AE, Woodliff J, Ghosh S, Lernmark A, Wang X, Hessner MJ.

J Immunol. 2006 Nov 15;177(10):7275-86.PMID: 17082646 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.

Wallis RH, Wang K, Dabrowski D, Marandi L, Ning T, Hsieh E, Paterson AD, Mordes JP, Blankenhorn EP, Poussier P.

Diabetes. 2007 Jun;56(6):1731-6. Epub 2007 Mar 27.PMID: 17389329 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic dissection of autoimmune type I diabetes in the BB rat.

Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark A, Lander ES.

Nat Genet. 1992 Sep;2(1):56-60. Erratum in: Nat Genet 1994 Jun;7(2):215. PMID: 1303251 [PubMed - indexed for MEDLINE]Related articles