PubMed

The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.

Dabrowski M, Ashcroft FM, Ashfield R, Lebrun P, Pirotte B, Egebjerg J, Bondo Hansen J, Wahl P.

Diabetes. 2002 Jun;51(6):1896-906.PMID: 12031979 [PubMed - indexed for MEDLINE]Related articlesFree article

Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.

Dabrowski M, Larsen T, Ashcroft FM, Bondo Hansen J, Wahl P.

Diabetologia. 2003 Oct;46(10):1375-82. Epub 2003 Sep 5.PMID: 12961066 [PubMed - indexed for MEDLINE]Related articles

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.

Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM.

J Physiol. 2003 Feb 15;547(Pt 1):159-68. Epub 2003 Jan 10.PMID: 12562963 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered functional properties of KATP channel conferred by a novel splice variant of SUR1.

Sakura H, Trapp S, Liss B, Ashcroft FM.

J Physiol. 1999 Dec 1;521 Pt 2:337-50.PMID: 10581306 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels.

Gribble FM, Tucker SJ, Seino S, Ashcroft FM.

Diabetes. 1998 Sep;47(9):1412-8.PMID: 9726229 [PubMed - indexed for MEDLINE]Related articlesFree article

C-terminal tails of sulfonylurea receptors control ADP-induced activation and diazoxide modulation of ATP-sensitive K(+) channels.

Matsuoka T, Matsushita K, Katayama Y, Fujita A, Inageda K, Tanemoto M, Inanobe A, Yamashita S, Matsuzawa Y, Kurachi Y.

Circ Res. 2000 Nov 10;87(10):873-80.PMID: 11073882 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.

Reimann F, Proks P, Ashcroft FM.

Br J Pharmacol. 2001 Apr;132(7):1542-8.PMID: 11264248 [PubMed - indexed for MEDLINE]Related articlesFree article

Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels.

Song DK, Ashcroft FM.

Br J Pharmacol. 2001 May;133(1):193-9.PMID: 11325810 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075.

Felsch H, Lange U, Hambrock A, Löffler-Walz C, Russ U, Carroll WA, Gopalakrishnan M, Quast U.

Br J Pharmacol. 2004 Apr;141(7):1098-105. Epub 2004 Mar 15.PMID: 15023854 [PubMed - indexed for MEDLINE]Related articlesFree article

Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.

Gribble FM, Reimann F, Ashfield R, Ashcroft FM.

Mol Pharmacol. 2000 Jun;57(6):1256-61.PMID: 10825398 [PubMed - indexed for MEDLINE]Related articlesFree article

Potassium channel openers require ATP to bind to and act through sulfonylurea receptors.

Schwanstecher M, Sieverding C, Dörschner H, Gross I, Aguilar-Bryan L, Schwanstecher C, Bryan J.

EMBO J. 1998 Oct 1;17(19):5529-35.PMID: 9755153 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensitivity of Kir6.2-SUR1 currents, in the absence and presence of sodium azide, to the K(ATP) channel inhibitors, ciclazindol and englitazone.

McKay NG, Kinsella JM, Campbell CM, Ashford ML.

Br J Pharmacol. 2000 Jun;130(4):857-66.PMID: 10864893 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.

Reimann F, Gribble FM, Ashcroft FM.

Mol Pharmacol. 2000 Dec;58(6):1318-25.PMID: 11093769 [PubMed - indexed for MEDLINE]Related articlesFree article

A transmembrane domain of the sulfonylurea receptor mediates activation of ATP-sensitive K(+) channels by K(+) channel openers.

D'hahan N, Jacquet H, Moreau C, Catty P, Vivaudou M.

Mol Pharmacol. 1999 Aug;56(2):308-15.PMID: 10419549 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression.

Jansen-Olesen I, Mortensen CH, El-Bariaki N, Ploug KB.

Eur J Pharmacol. 2005 Oct 31;523(1-3):109-18. Epub 2005 Oct 13.PMID: 16226739 [PubMed - indexed for MEDLINE]Related articles

The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.

Tammaro P, Ashcroft F.

J Physiol. 2007 Jun 15;581(Pt 3):1259-69. Epub 2007 Mar 29.PMID: 17395632 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.

Ashfield R, Gribble FM, Ashcroft SJ, Ashcroft FM.

Diabetes. 1999 Jun;48(6):1341-7.PMID: 10342826 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding.

Matsuo M, Dabrowski M, Ueda K, Ashcroft FM.

EMBO J. 2002 Aug 15;21(16):4250-8.PMID: 12169627 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels.

Dabrowski M, Wahl P, Holmes WE, Ashcroft FM.

Diabetologia. 2001 Jun;44(6):747-56.PMID: 11440368 [PubMed - indexed for MEDLINE]Related articles

The actions of a novel potent islet beta-cell specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1.

Ng B, Kang Y, Elias CL, He Y, Xie H, Hansen JB, Wahl P, Gaisano HY.

Diabetes. 2007 Aug;56(8):2124-34. Epub 2007 May 11.PMID: 17496234 [PubMed - indexed for MEDLINE]Related articlesFree article