PubMed

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.

Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S.

Diabetes. 2002 Jun;51(6):1793-804.PMID: 12031967 [PubMed - indexed for MEDLINE]Related articlesFree article

The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells.

Lottmann H, Vanselow J, Hessabi B, Walther R.

J Mol Med. 2001 Jun;79(5-6):321-8.PMID: 11485027 [PubMed - indexed for MEDLINE]Related articles

In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4.

Hino S, Yamaoka T, Yamashita Y, Yamada T, Hata J, Itakura M.

Diabetologia. 2004 Oct;47(10):1819-30. Epub 2004 Oct 6.PMID: 15480536 [PubMed - indexed for MEDLINE]Related articles

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrín M, Gros L, Bosch F.

J Clin Invest. 2000 Mar;105(6):731-40.PMID: 10727441 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.

Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV.

Development. 2000 Jul;127(13):2883-95.PMID: 10851133 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

Endocrinology. 2002 Apr;143(4):1530-7.PMID: 11897712 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells.

Welsh M, Christmansson L, Karlsson T, Sandler S, Welsh N.

Mol Med. 1999 Mar;5(3):169-80.PMID: 10404514 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.

Petrik J, Pell JM, Arany E, McDonald TJ, Dean WL, Reik W, Hill DJ.

Endocrinology. 1999 May;140(5):2353-63.PMID: 10218989 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

Yamagata K, Nammo T, Moriwaki M, Ihara A, Iizuka K, Yang Q, Satoh T, Li M, Uenaka R, Okita K, Iwahashi H, Zhu Q, Cao Y, Imagawa A, Tochino Y, Hanafusa T, Miyagawa J, Matsuzawa Y.

Diabetes. 2002 Jan;51(1):114-23.PMID: 11756330 [PubMed - indexed for MEDLINE]Related articlesFree article

Recovery of pancreatic beta cells in response to long-term normoglycemia after pancreas or islet transplantation in severely streptozotocin diabetic adult rats.

Jörns A, Klempnauer J, Tiedge M, Lenzen S.

Pancreas. 2001 Aug;23(2):186-96.PMID: 11484921 [PubMed - indexed for MEDLINE]Related articles

A 338-bp proximal fragment of the glucose transporter type 2 (GLUT2) promoter drives reporter gene expression in the pancreatic islets of transgenic mice.

Waeber G, Pedrazzini T, Bonny O, Bonny C, Steinmann M, Nicod P, Haefliger JA.

Mol Cell Endocrinol. 1995 Oct 30;114(1-2):205-15.PMID: 8674846 [PubMed - indexed for MEDLINE]Related articles

Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets.

Pascal SM, Guiot Y, Pelengaris S, Khan M, Jonas JC.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E92-102. Epub 2008 Apr 15.PMID: 18413670 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice.

García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC, Stewart AF.

Diabetes. 2001 Dec;50(12):2752-62.PMID: 11723058 [PubMed - indexed for MEDLINE]Related articlesFree article

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, Kreutter DK, Butler PC.

Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7283-8.PMID: 8692984 [PubMed - indexed for MEDLINE]Related articlesFree article

Systemic treatment with sympatholytic dopamine agonists improves aberrant beta-cell hyperplasia and GLUT2, glucokinase, and insulin immunoreactive levels in ob/ob mice.

Jetton TL, Liang Y, Cincotta AH.

Metabolism. 2001 Nov;50(11):1377-84.PMID: 11699060 [PubMed - indexed for MEDLINE]Related articles

Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats.

Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC.

Diabetologia. 2007 Oct;50(10):2117-25. Epub 2007 Jul 20.PMID: 17641871 [PubMed - indexed for MEDLINE]Related articles

The loss of GLUT2 expression in the pancreatic beta-cells of diabetic db/db mice is associated with an impaired DNA-binding activity of islet-specific trans-acting factors.

Bonny C, Roduit R, Gremlich S, Nicod P, Thorens B, Waeber G.

Mol Cell Endocrinol. 1997 Nov 30;135(1):59-65.PMID: 9453241 [PubMed - indexed for MEDLINE]Related articles

Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.

D'Alessio DA, Verchere CB, Kahn SE, Hoagland V, Baskin DG, Palmiter RD, Ensinck JW.

Diabetes. 1994 Dec;43(12):1457-61.PMID: 7958499 [PubMed - indexed for MEDLINE]Related articles

Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation.

Kaneto H, Sharma A, Suzuma K, Laybutt DR, Xu G, Bonner-Weir S, Weir GC.

J Biol Chem. 2002 Apr 12;277(15):12998-3006. Epub 2002 Jan 17.PMID: 11799123 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance.

Dai C, Huh CG, Thorgeirsson SS, Liu Y.

Am J Pathol. 2005 Aug;167(2):429-36.PMID: 16049329 [PubMed - indexed for MEDLINE]Related articlesFree article