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    Results: 1 to 20 of 532

    1.

    Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.

    Yang Q, Yamagata K, Fukui K, Cao Y, Nammo T, Iwahashi H, Wang H, Matsumura I, Hanafusa T, Bucala R, Wollheim CB, Miyagawa J, Matsuzawa Y.

    Diabetes. 2002 Jun;51(6):1785-92.PMID: 12031966 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

    Yamagata K, Nammo T, Moriwaki M, Ihara A, Iizuka K, Yang Q, Satoh T, Li M, Uenaka R, Okita K, Iwahashi H, Zhu Q, Cao Y, Imagawa A, Tochino Y, Hanafusa T, Miyagawa J, Matsuzawa Y.

    Diabetes. 2002 Jan;51(1):114-23.PMID: 11756330 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.

    Richter S, Shih DQ, Pearson ER, Wolfrum C, Fajans SS, Hattersley AT, Stoffel M.

    Diabetes. 2003 Dec;52(12):2989-95.PMID: 14633861 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1alpha is dominant negative.

    Yamagata K, Yang Q, Yamamoto K, Iwahashi H, Miyagawa J, Okita K, Yoshiuchi I, Miyazaki J, Noguchi T, Nakajima H, Namba M, Hanafusa T, Matsuzawa Y.

    Diabetes. 1998 Aug;47(8):1231-5.PMID: 9703322 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

    Wang H, Maechler P, Hagenfeldt KA, Wollheim CB.

    EMBO J. 1998 Nov 16;17(22):6701-13.PMID: 9822613 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.

    Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M.

    Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3818-23.PMID: 11904435 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.

    Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, Levisetti M, Bonner-Weir S, Bell GI, Yaniv M, Polonsky KS.

    J Clin Invest. 1998 May 15;101(10):2215-22.PMID: 9593777 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.

    Shih DQ, Screenan S, Munoz KN, Philipson L, Pontoglio M, Yaniv M, Polonsky KS, Stoffel M.

    Diabetes. 2001 Nov;50(11):2472-80.PMID: 11679424 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.

    Wang H, Antinozzi PA, Hagenfeldt KA, Maechler P, Wollheim CB.

    EMBO J. 2000 Aug 15;19(16):4257-64.PMID: 10944108 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.

    Wobser H, Düssmann H, Kögel D, Wang H, Reimertz C, Wollheim CB, Byrne MM, Prehn JH.

    J Biol Chem. 2002 Feb 22;277(8):6413-21. Epub 2001 Nov 27.PMID: 11724785 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Overexpression of dominant negative mutant hepatocyte nuclear factor (HNF)-1alpha inhibits arginine-induced insulin secretion in MIN6 cells.

    Tanizawa Y, Ohta Y, Nomiyama J, Matsuda K, Tanabe K, Inoue H, Matsutani A, Okuya S, Oka Y.

    Diabetologia. 1999 Jul;42(7):887-91.PMID: 10440133 [PubMed - indexed for MEDLINE]Related articles

    12.

    Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.

    Okita K, Yang Q, Yamagata K, Hangenfeldt KA, Miyagawa J, Kajimoto Y, Nakajima H, Namba M, Wollheim CB, Hanafusa T, Matsuzawa Y.

    Biochem Biophys Res Commun. 1999 Sep 24;263(2):566-9.PMID: 10491332 [PubMed - indexed for MEDLINE]Related articles

    13.

    Decreased glibenclamide uptake in hepatocytes of hepatocyte nuclear factor-1alpha-deficient mice: a mechanism for hypersensitivity to sulfonylurea therapy in patients with maturity-onset diabetes of the young, type 3 (MODY3).

    Boileau P, Wolfrum C, Shih DQ, Yang TA, Wolkoff AW, Stoffel M.

    Diabetes. 2002 Dec;51 Suppl 3:S343-8.PMID: 12475773 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.

    Hagenfeldt-Johansson KA, Herrera PL, Wang H, Gjinovci A, Ishihara H, Wollheim CB.

    Endocrinology. 2001 Dec;142(12):5311-20.PMID: 11713231 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

    Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW.

    J Biol Chem. 2009 Jun 19;284(25):16808-21. Epub 2009 Apr 17.PMID: 19376774 [PubMed - indexed for MEDLINE]Related articles

    16.

    beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.

    Pearson ER, Velho G, Clark P, Stride A, Shepherd M, Frayling TM, Bulman MP, Ellard S, Froguel P, Hattersley AT.

    Diabetes. 2001 Feb;50 Suppl 1:S101-7.PMID: 11272165 [PubMed - indexed for MEDLINE]Related articles

    17.

    Experimental models of transcription factor-associated maturity-onset diabetes of the young.

    Wang H, Hagenfeldt-Johansson K, Otten LA, Gauthier BR, Herrera PL, Wollheim CB.

    Diabetes. 2002 Dec;51 Suppl 3:S333-42. Review.PMID: 12475772 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice.

    Dukes ID, Sreenan S, Roe MW, Levisetti M, Zhou YP, Ostrega D, Bell GI, Pontoglio M, Yaniv M, Philipson L, Polonsky KS.

    J Biol Chem. 1998 Sep 18;273(38):24457-64.PMID: 9733737 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Regulation of human insulin, IGF-I, and multidrug resistance protein 2 promoter activity by hepatocyte nuclear factor (HNF)-1beta and HNF-1alpha and the abnormality of HNF-1beta mutants.

    Kitanaka S, Sato U, Igarashi T.

    J Endocrinol. 2007 Jan;192(1):141-7.PMID: 17210751 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Structure/function studies of hepatocyte nuclear factor-1alpha, a diabetes-associated transcription factor.

    Yang Q, Yamagata K, Yamamoto K, Miyagawa J, Takeda J, Iwasaki N, Iwahashi H, Yoshiuchi I, Namba M, Miyazaki J, Hanafusa T, Matsuzawa Y.

    Biochem Biophys Res Commun. 1999 Dec 9;266(1):196-202.PMID: 10581189 [PubMed - indexed for MEDLINE]Related articles

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