PubMed

A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.

Brennan L, Shine A, Hewage C, Malthouse JP, Brindle KM, McClenaghan N, Flatt PR, Newsholme P.

Diabetes. 2002 Jun;51(6):1714-21.PMID: 12031957 [PubMed - indexed for MEDLINE]Related articlesFree article

13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line.

Brennan L, Corless M, Hewage C, Malthouse JP, McClenaghan NH, Flatt PR, Newsholme P.

Diabetologia. 2003 Nov;46(11):1512-21. Epub 2003 Sep 4.PMID: 12955201 [PubMed - indexed for MEDLINE]Related articles

A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine.

Dixon G, Nolan J, McClenaghan N, Flatt PR, Newsholme P.

J Endocrinol. 2003 Dec;179(3):447-54.PMID: 14656214 [PubMed - indexed for MEDLINE]Related articlesFree article

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.

Dixon G, Nolan J, McClenaghan NH, Flatt PR, Newsholme P.

Clin Sci (Lond). 2004 Feb;106(2):191-9.PMID: 14561212 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line.

McClenaghan NH, Barnett CR, O'Harte FP, Flatt PR.

J Endocrinol. 1996 Dec;151(3):349-57.PMID: 8994380 [PubMed - indexed for MEDLINE]Related articles

Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.

Patterson S, Flatt PR, Brennan L, Newsholme P, McClenaghan NH.

J Endocrinol. 2006 May;189(2):301-10.PMID: 16648297 [PubMed - indexed for MEDLINE]Related articlesFree article

Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line.

Kiely A, McClenaghan NH, Flatt PR, Newsholme P.

J Endocrinol. 2007 Oct;195(1):113-23.PMID: 17911403 [PubMed - indexed for MEDLINE]Related articlesFree article

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS).

Lu D, Mulder H, Zhao P, Burgess SC, Jensen MV, Kamzolova S, Newgard CB, Sherry AD.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2708-13.PMID: 11880625 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets.

Carobbio S, Ishihara H, Fernandez-Pascual S, Bartley C, Martin-Del-Rio R, Maechler P.

Diabetologia. 2004 Feb;47(2):266-76. Epub 2003 Dec 20.PMID: 14689183 [PubMed - indexed for MEDLINE]Related articles

Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart.

Lloyd S, Brocks C, Chatham JC.

Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H163-72.PMID: 12793977 [PubMed - indexed for MEDLINE]Related articlesFree article

13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells.

Cline GW, Lepine RL, Papas KK, Kibbey RG, Shulman GI.

J Biol Chem. 2004 Oct 22;279(43):44370-5. Epub 2004 Aug 9.PMID: 15304488 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of glucose and glyburide on energetics and Na+ levels of betaHC9 cells: nuclear magnetic resonance spectroscopy and respirometry studies.

Doliba NM, Vatamaniuk MZ, Buettger CW, Qin W, Collins HW, Wehrli SL, Carr RD, Matschinsky FM.

Diabetes. 2003 Feb;52(2):394-402.PMID: 12540613 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion.

McClenaghan NH, Barnett CR, Ah-Sing E, Abdel-Wahab YH, O'Harte FP, Yoon TW, Swanston-Flatt SK, Flatt PR.

Diabetes. 1996 Aug;45(8):1132-40.PMID: 8690162 [PubMed - indexed for MEDLINE]Related articles

The stimulus-secretion coupling of amino acid-induced insulin release. Insulinotropic action of L-alanine.

Sener A, Malaisse WJ.

Biochim Biophys Acta. 2002 Oct 10;1573(1):100-4.PMID: 12383948 [PubMed - indexed for MEDLINE]Related articles

Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion.

Ainscow EK, Zhao C, Rutter GA.

Diabetes. 2000 Jul;49(7):1149-55.PMID: 10909972 [PubMed - indexed for MEDLINE]Related articlesFree article

Human interleukin-1 beta induced stimulation of insulin release from rat pancreatic islets is accompanied by an increase in mitochondrial oxidative events.

Eizirik DL, Sandler S.

Diabetologia. 1989 Nov;32(11):769-73.PMID: 2687062 [PubMed - indexed for MEDLINE]Related articles

A high affinity glutamate/aspartate transport system in pancreatic islets of Langerhans modulates glucose-stimulated insulin secretion.

Weaver CD, Gundersen V, Verdoorn TA.

J Biol Chem. 1998 Jan 16;273(3):1647-53.PMID: 9430708 [PubMed - indexed for MEDLINE]Related articlesFree article

Importance of lactate dehydrogenase for the regulation of glycolytic flux and insulin secretion in insulin-producing cells.

Alcazar O, Tiedge M, Lenzen S.

Biochem J. 2000 Dec 1;352 Pt 2:373-80.PMID: 11085930 [PubMed - indexed for MEDLINE]Related articlesFree article

Engineering cultured insulin-secreting pancreatic B-cell lines.

McClenaghan NH, Flatt PR.

J Mol Med. 1999 Jan;77(1):235-43. Review.PMID: 9930971 [PubMed - indexed for MEDLINE]Related articles

Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.

Bender K, Maechler P, McClenaghan NH, Flatt PR, Newsholme P.

Clin Sci (Lond). 2009 Sep 1;117(9):321-30.PMID: 19344310 [PubMed - indexed for MEDLINE]Related articles