PubMed

Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses.

Chan O, Chan S, Inouye K, Shum K, Matthews SG, Vranic M.

Diabetes. 2002 Jun;51(6):1681-9.PMID: 12031953 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia.

Chan O, Inouye K, Akirav EM, Park E, Riddell MC, Matthews SG, Vranic M.

Am J Physiol Regul Integr Comp Physiol. 2005 Jul;289(1):R235-46. Epub 2005 Mar 17.PMID: 15774766 [PubMed - indexed for MEDLINE]Related articles

Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment.

Chan O, Chan S, Inouye K, Vranic M, Matthews SG.

Endocrinology. 2001 Nov;142(11):4872-9.PMID: 11606455 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses.

Chan O, Inouye K, Akirav E, Park E, Riddell MC, Vranic M, Matthews SG.

Endocrinology. 2005 Mar;146(3):1382-90. Epub 2004 Nov 24.PMID: 15564337 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity.

Chan O, Inouye K, Vranic M, Matthews SG.

Endocrinology. 2002 May;143(5):1761-8.PMID: 11956158 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia.

Flanagan DE, Keshavarz T, Evans ML, Flanagan S, Fan X, Jacob RJ, Sherwin RS.

Diabetes. 2003 Mar;52(3):605-13.PMID: 12606499 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis.

Inouye KE, Chan O, Yue JT, Matthews SG, Vranic M.

Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E422-9. Epub 2004 Oct 19.PMID: 15494609 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes.

Schwartz MW, Strack AM, Dallman MF.

Regul Pept. 1997 Oct 31;72(2-3):105-12.PMID: 9652969 [PubMed - indexed for MEDLINE]Related articles

Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats.

Inouye KE, Yue JT, Chan O, Kim T, Akirav EM, Park E, Riddell MC, Burdett E, Matthews SG, Vranic M.

Endocrinology. 2006 Apr;147(4):1860-70. Epub 2006 Jan 5.PMID: 16396986 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a hypothalamic-pituitary versus adrenal cortical effect of glycemic control on counterregulatory hormone responses to hypoglycemia in insulin-dependent diabetes mellitus.

Kinsley BT, Simonson DC.

J Clin Endocrinol Metab. 1996 Feb;81(2):684-91.PMID: 8636289 [PubMed - indexed for MEDLINE]Related articles

Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats.

Inouye K, Shum K, Chan O, Mathoo J, Matthews SG, Vranic M.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1369-79.PMID: 12006368 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of insulin-induced hypoglycemia on gene expression in the hypothalamic-pituitary-adrenal axis of the rat.

Robinson BG, Mealy K, Wilmore DW, Majzoub JA.

Endocrinology. 1992 Feb;130(2):920-5.PMID: 1310284 [PubMed - indexed for MEDLINE]Related articles

Effect of repeated lipopolysaccharide administration on tissue cytokine expression and hypothalamic-pituitary-adrenal axis activity in rats.

Grinevich V, Ma XM, Herman JP, Jezova D, Akmayev I, Aguilera G.

J Neuroendocrinol. 2001 Aug;13(8):711-23.PMID: 11489088 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of impaired hypothalamic-pituitary-adrenal (HPA) function in diabetes: reduced counterregulatory responsiveness to hypoglycaemia.

Inouye K, Chan O, Riddell MC, Akirav E, Matthews SG, Vranic M.

Diabetes Nutr Metab. 2002 Oct;15(5):348-55; discussion 355-6, 362. Review.PMID: 12625483 [PubMed - indexed for MEDLINE]Related articles

Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats.

Akirav EM, Chan O, Inouye K, Riddell MC, Matthews SG, Vranic M.

Metabolism. 2004 Dec;53(12):1558-64.PMID: 15562400 [PubMed - indexed for MEDLINE]Related articles

Altered control of the hypothalamo-pituitary-adrenal axis in adult male rats exposed perinatally to food deprivation and/or dehydration.

Sebaai N, Lesage J, Vieau D, Alaoui A, Dupouy JP, Deloof S.

Neuroendocrinology. 2002 Oct;76(4):243-53.PMID: 12411741 [PubMed - indexed for MEDLINE]Related articles

Alterations in hypothalamic-pituitary-adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic 'binge' cocaine and withdrawal.

Zhou Y, Spangler R, Schlussman SD, Ho A, Kreek MJ.

Brain Res. 2003 Feb 28;964(2):187-99.PMID: 12576179 [PubMed - indexed for MEDLINE]Related articles

Acute glucocorticoid pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis hormone secretion and expression of corticotropin-releasing hormone hnRNA but does not affect c-fos mRNA or fos protein expression in the paraventricular nucleus of the hypothalamus.

Ginsberg AB, Campeau S, Day HE, Spencer RL.

J Neuroendocrinol. 2003 Nov;15(11):1075-83.PMID: 14622438 [PubMed - indexed for MEDLINE]Related articles

Effects of prenatal ethanol exposure on basal limbic-hypothalamic-pituitary-adrenal regulation: role of corticosterone.

Glavas MM, Ellis L, Yu WK, Weinberg J.

Alcohol Clin Exp Res. 2007 Sep;31(9):1598-610.PMID: 17760789 [PubMed - indexed for MEDLINE]Related articles

Experimentally-induced hyperthyroidism is associated with activation of the rat hypothalamic-pituitary-adrenal axis.

Johnson EO, Kamilaris TC, Calogero AE, Gold PW, Chrousos GP.

Eur J Endocrinol. 2005 Jul;153(1):177-85.PMID: 15994759 [PubMed - indexed for MEDLINE]Related articlesFree article