PubMed

A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal: a potential therapy for type 2 diabetes.

Tsutsumi M, Claus TH, Liang Y, Li Y, Yang L, Zhu J, Dela Cruz F, Peng X, Chen H, Yung SL, Hamren S, Livingston JN, Pan CQ.

Diabetes. 2002 May;51(5):1453-60.PMID: 11978642 [PubMed - indexed for MEDLINE]Related articlesFree article

Pituitary adenylate cyclase-activating polypeptide receptors mediating insulin secretion in rodent pancreatic islets are coupled to adenylate cyclase but not to PLC.

Jamen F, Puech R, Bockaert J, Brabet P, Bertrand G.

Endocrinology. 2002 Apr;143(4):1253-9.PMID: 11897681 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation of highly selective VPAC2 receptor agonists by high throughput mutagenesis of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide.

Yung SL, Dela Cruz F, Hamren S, Zhu J, Tsutsumi M, Bloom JW, Caudle M, Roczniak S, Todd T, Lemoine L, MacDougall M, Shanafelt AB, Pan CQ.

J Biol Chem. 2003 Mar 21;278(12):10273-81. Epub 2003 Jan 13.PMID: 12525492 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytosolic Ca2+ responses to sub-picomolar and nanomolar PACAP in pancreatic beta-cells are mediated by VPAC2 and PAC1 receptors.

Yamada H, Watanabe M, Yada T.

Regul Pept. 2004 Dec 15;123(1-3):147-53.PMID: 15518905 [PubMed - indexed for MEDLINE]Related articles

VPAC2-R mediates the lipolytic effects of pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide in primary rat adipocytes.

Akesson L, Ahrén B, Edgren G, Degerman E.

Endocrinology. 2005 Feb;146(2):744-50. Epub 2004 Oct 28.PMID: 15514088 [PubMed - indexed for MEDLINE]Related articlesFree article

A cloned frog vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating polypeptide receptor exhibits pharmacological and tissue distribution characteristics of both VPAC1 and VPAC2 receptors in mammals.

Alexandre D, Anouar Y, Jegou S, Fournier A, Vaudry H.

Endocrinology. 1999 Mar;140(3):1285-93.PMID: 10067855 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for the involvement of VPAC1 and VPAC2 receptors in pressure-induced vasodilatation in rodents.

Fizanne L, Sigaudo-Roussel D, Saumet JL, Fromy B.

J Physiol. 2004 Jan 15;554(Pt 2):519-28. Epub 2003 Oct 24.PMID: 14578481 [PubMed - indexed for MEDLINE]Related articlesFree article

Pituitary adenylate cyclase-activating polypeptide and PACAP receptor expression and function in the rat adrenal gland.

Mazzocchi G, Malendowicz LK, Neri G, Andreis PG, Ziolkowska A, Gottardo L, Nowak KW, Nussdorfer GG.

Int J Mol Med. 2002 Mar;9(3):233-43.PMID: 11836629 [PubMed - indexed for MEDLINE]Related articles

A lymphocyte-generated fragment of vasoactive intestinal peptide with VPAC1 agonist activity and VPAC2 antagonist effects.

Summers MA, O'Dorisio MS, Cox MO, Lara-Marquez M, Goetzl EJ.

J Pharmacol Exp Ther. 2003 Aug;306(2):638-45. Epub 2003 May 15.PMID: 12750439 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide.

Nicole P, Lins L, Rouyer-Fessard C, Drouot C, Fulcrand P, Thomas A, Couvineau A, Martinez J, Brasseur R, Laburthe M.

J Biol Chem. 2000 Aug 4;275(31):24003-12.PMID: 10801840 [PubMed - indexed for MEDLINE]Related articlesFree article

Vasoactive intestinal peptide (VIP) stimulates cortisol secretion from the H295 human adrenocortical tumour cell line via VPAC1 receptors.

Nicol MR, Cobb VJ, Williams BC, Morley SD, Walker SW, Mason JI.

J Mol Endocrinol. 2004 Jun;32(3):869-77.PMID: 15171718 [PubMed - indexed for MEDLINE]Related articlesFree article

PACAP/VIP receptors in pancreatic beta-cells: their roles in insulin secretion.

Inagaki N, Kuromi H, Seino S.

Ann N Y Acad Sci. 1996 Dec 26;805:44-51; discussion 52-3. Review.PMID: 8993392 [PubMed - indexed for MEDLINE]Related articles

Distribution of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC1, VPAC2, and PAC1 receptor) in the rat brain.

Joo KM, Chung YH, Kim MK, Nam RH, Lee BL, Lee KH, Cha CI.

J Comp Neurol. 2004 Aug 30;476(4):388-413.PMID: 15282712 [PubMed - indexed for MEDLINE]Related articles

Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide inhibit dendritic growth in cultured sympathetic neurons.

Drahushuk K, Connell TD, Higgins D.

J Neurosci. 2002 Aug 1;22(15):6560-9.PMID: 12151535 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel recombinant, VPAC2-selective agonist enhancing insulin release and glucose disposal.

Yu RJ, Tam NL, Gao Y, Zeng ZH, Zhou TH, Hong A.

Acta Pharmacol Sin. 2007 Apr;28(4):526-33.PMID: 17376292 [PubMed - indexed for MEDLINE]Related articlesFree article

Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin.

Reubi JC, Läderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA.

Cancer Res. 2000 Jun 1;60(11):3105-12.PMID: 10850463 [PubMed - indexed for MEDLINE]Related articlesFree article

The long-acting vasoactive intestinal polypeptide agonist RO 25-1553 is highly selective of the VIP2 receptor subclass.

Gourlet P, Vertongen P, Vandermeers A, Vandermeers-Piret MC, Rathe J, De Neef P, Waelbroeck M, Robberecht P.

Peptides. 1997;18(3):403-8.PMID: 9145428 [PubMed - indexed for MEDLINE]Related articles

Role of VIP and PACAP in islet function.

Winzell MS, Ahrén B.

Peptides. 2007 Sep;28(9):1805-13. Epub 2007 May 6. Review.PMID: 17559974 [PubMed - indexed for MEDLINE]Related articles

(N-stearyl, norleucine17)VIPhybrid is a broad spectrum vasoactive intestinal peptide receptor antagonist.

Moody TW, Jensen RT, Fridkin M, Gozes I.

J Mol Neurosci. 2002 Feb-Apr;18(1-2):29-35.PMID: 11931347 [PubMed - indexed for MEDLINE]Related articles

Localisation of VIP-binding sites exhibiting properties of VPAC receptors in chromaffin cells of rainbow trout (Oncorhynchus mykiss).

Montpetit CJ, Shahsavarani A, Perry SF.

J Exp Biol. 2003 Jun;206(Pt 11):1917-27.PMID: 12728013 [PubMed - indexed for MEDLINE]Related articlesFree article