PubMed

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P.

Diabetes. 2002 May;51(5):1437-42.PMID: 11978640 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets.

Marselli L, Trincavelli L, Santangelo C, Lupi R, Del Guerra S, Boggi U, Falleni A, Gremigni V, Mosca F, Martini C, Dotta F, Di Mario U, Del Prato S, Marchetti P.

Eur J Endocrinol. 2004 Aug;151(2):207-14.PMID: 15296476 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S.

Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E560-7. Epub 2003 Nov 18.PMID: 14625208 [PubMed - indexed for MEDLINE]Related articlesFree article

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG.

Diabetes. 2001 Aug;50(8):1771-7.PMID: 11473037 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

Patanè G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F.

Diabetes. 2000 May;49(5):735-40.PMID: 10905481 [PubMed - indexed for MEDLINE]Related articlesFree article

The non-peptidyl low molecular weight radical scavenger IAC protects human pancreatic islets from lipotoxicity.

D'Aleo V, Del Guerra S, Martano M, Bonamassa B, Canistro D, Soleti A, Valgimigli L, Paolini M, Filipponi F, Boggi U, Del Prato S, Lupi R.

Mol Cell Endocrinol. 2009 Oct 15;309(1-2):63-6. Epub 2009 May 27.PMID: 19481137 [PubMed - indexed for MEDLINE]Related articles

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.

Shimabukuro M, Zhou YT, Levi M, Unger RH.

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2498-502.PMID: 9482914 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipotoxicity in human pancreatic islets and the protective effect of metformin.

Lupi R, Del Guerra S, Fierabracci V, Marselli L, Novelli M, Patanè G, Boggi U, Mosca F, Piro S, Del Prato S, Marchetti P.

Diabetes. 2002 Feb;51 Suppl 1:S134-7.PMID: 11815472 [PubMed - indexed for MEDLINE]Related articlesFree article

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.

Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY.

Diabetes. 2003 Mar;52(3):726-33.PMID: 12606514 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function.

Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY.

Diabetes. 2001 Jan;50(1):69-76.PMID: 11147797 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ.

J Biol Chem. 2002 Dec 20;277(51):49676-84. Epub 2002 Oct 21.PMID: 12393870 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.

Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R.

Endocrinology. 2003 Dec;144(12):5149-58. Epub 2003 Aug 28.PMID: 12960095 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of prolonged exposure to pancreatic glucagon on the function, antigenicity and survival of isolated human islets.

Del Guerra S, Lupi R, Dotta F, Marselli L, Lencioni C, Santangelo C, Realacci M, Carmellini M, Mosca F, Navalesi R, Marchetti P.

Diabetes Metab Res Rev. 2000 Jul-Aug;16(4):281-6.PMID: 10934457 [PubMed - indexed for MEDLINE]Related articles

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.

Zhou YP, Grill V.

J Clin Endocrinol Metab. 1995 May;80(5):1584-90.PMID: 7745004 [PubMed - indexed for MEDLINE]Related articles

Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells.

D'Alessandris C, Andreozzi F, Federici M, Cardellini M, Brunetti A, Ranalli M, Del Guerra S, Lauro D, Del Prato S, Marchetti P, Lauro R, Sesti G.

FASEB J. 2004 Jun;18(9):959-61. Epub 2004 Apr 1.PMID: 15059979 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct apoptotic effects of free fatty acids on human endothelial cells.

Piro S, Spampinato D, Spadaro L, Oliveri CE, Purrello F, Rabuazzo AM.

Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):96-104. Epub 2007 Jun 8.PMID: 17560770 [PubMed - indexed for MEDLINE]Related articles

Non-esterified fatty acids are deleterious for human pancreatic islet function at physiological glucose concentration.

Dubois M, Kerr-Conte J, Gmyr V, Bouckenooghe T, Muharram G, D'Herbomez M, Martin-Ponthieu A, Vantyghem MC, Vandewalle B, Pattou F.

Diabetologia. 2004 Mar;47(3):463-9. Epub 2004 Feb 13.PMID: 14968298 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

Augmentation of Ca2+-stimulated insulin release by glucose and long-chain fatty acids in rat pancreatic islets: free fatty acids mimic ATP-sensitive K+ channel-independent insulinotropic action of glucose.

Komatsu M, Yajima H, Yamada S, Kaneko T, Sato Y, Yamauchi K, Hashizume K, Aizawa T.

Diabetes. 1999 Aug;48(8):1543-9.PMID: 10426371 [PubMed - indexed for MEDLINE]Related articlesFree article