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    Results: 1 to 20 of 232

    1.

    Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism.

    Marchetti P, Lupi R, Federici M, Marselli L, Masini M, Boggi U, Del Guerra S, Patanè G, Piro S, Anello M, Bergamini E, Purrello F, Lauro R, Mosca F, Sesti G, Del Prato S.

    Diabetes. 2002 May;51(5):1419-24.PMID: 11978638 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells.

    Porzio O, Federici M, Hribal ML, Lauro D, Accili D, Lauro R, Borboni P, Sesti G.

    J Clin Invest. 1999 Aug;104(3):357-64.PMID: 10430617 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

    Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T.

    J Clin Invest. 1997 Mar 1;99(5):861-6.PMID: 9062343 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans.

    Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, Maerker E, Teigeler A, Koch M, Machicao F, Häring H.

    Diabetes. 2001 Apr;50(4):882-5.PMID: 11289056 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Common amino acid substitutions in insulin receptor substrate-4 are not associated with Type II diabetes mellitus or insulin resistance.

    Almind K, Frederiksen SK, Ahlgren MG, Urhammer S, Hansen T, Clausen JO, Pedersen O.

    Diabetologia. 1998 Aug;41(8):969-74.PMID: 9726601 [PubMed - indexed for MEDLINE]Related articles

    6.

    Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes.

    Koch M, Rett K, Volk A, Maerker E, Haist K, Deninger M, Renn W, Häring HU.

    Exp Clin Endocrinol Diabetes. 1999;107(5):318-22.PMID: 10482045 [PubMed - indexed for MEDLINE]Related articles

    7.

    Clinical characterization of insulin secretion as the basis for genetic analyses.

    Stumvoll M, Fritsche A, Häring HU.

    Diabetes. 2002 Feb;51 Suppl 1:S122-9. Review.PMID: 11815470 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

    Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, Satoh S, Sekihara H, Sciacchitano S, Lesniak M, Aizawa S, Nagai R, Kimura S, Akanuma Y, Taylor SI, Kadowaki T.

    Diabetes. 2000 Nov;49(11):1880-9.PMID: 11078455 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene.

    Perticone F, Sciacqua A, Scozzafava A, Ventura G, Laratta E, Pujia A, Federici M, Lauro R, Sesti G.

    J Clin Endocrinol Metab. 2004 Jul;89(7):3606-9.PMID: 15240653 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.

    Ehrmann DA, Tang X, Yoshiuchi I, Cox NJ, Bell GI.

    J Clin Endocrinol Metab. 2002 Sep;87(9):4297-300.PMID: 12213887 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

    't Hart LM, Nijpels G, Dekker JM, Maassen JA, Heine RJ, van Haeften TW.

    Diabetes. 2002 Mar;51(3):884-7.PMID: 11872698 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.

    Esposito DL, Li Y, Vanni C, Mammarella S, Veschi S, Della Loggia F, Mariani-Costantini R, Battista P, Quon MJ, Cama A.

    J Clin Endocrinol Metab. 2003 Apr;88(4):1468-75.PMID: 12679424 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.

    Almind K, Frederiksen SK, Bernal D, Hansen T, Ambye L, Urhammer S, Ekstrøm CT, Berglund L, Reneland R, Lithell H, White MF, Van Obberghen E, Pedersen O.

    Diabetologia. 1999 Oct;42(10):1244-9.PMID: 10525667 [PubMed - indexed for MEDLINE]Related articles

    14.

    The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy.

    Federici M, Petrone A, Porzio O, Bizzarri C, Lauro D, D'Alfonso R, Patera I, Cappa M, Nisticò L, Baroni M, Sesti G, di Mario U, Lauro R, Buzzetti R.

    Diabetes. 2003 Mar;52(3):887-90.PMID: 12606535 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies.

    van Dam RM, Hoebee B, Seidell JC, Schaap MM, Blaak EE, Feskens EJ.

    Diabet Med. 2004 Jul;21(7):752-8.PMID: 15209769 [PubMed - indexed for MEDLINE]Related articles

    16.

    Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.

    Anello M, Lupi R, Spampinato D, Piro S, Masini M, Boggi U, Del Prato S, Rabuazzo AM, Purrello F, Marchetti P.

    Diabetologia. 2005 Feb;48(2):282-9. Epub 2005 Jan 15.PMID: 15654602 [PubMed - indexed for MEDLINE]Related articles

    17.

    The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.

    Marini MA, Frontoni S, Mineo D, Bracaglia D, Cardellini M, De Nicolais P, Baroni A, D'Alfonso R, Perna M, Lauro D, Federici M, Gambardella S, Lauro R, Sesti G.

    J Clin Endocrinol Metab. 2003 Jul;88(7):3368-71.PMID: 12843189 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes.

    Mammarella S, Romano F, Di Valerio A, Creati B, Esposito DL, Palmirotta R, Capani F, Vitullo P, Volpe G, Battista P, Della Loggia F, Mariani-Costantini R, Cama A.

    Hum Mol Genet. 2000 Oct 12;9(17):2517-21.PMID: 11030756 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

    Sesti G, Marini MA, Cardellini M, Sciacqua A, Frontoni S, Andreozzi F, Irace C, Lauro D, Gnasso A, Federici M, Perticone F, Lauro R.

    Diabetes Care. 2004 Jun;27(6):1394-8.PMID: 15161794 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Restoration of insulin secretion in pancreatic islets of protein-deficient rats by reduced expression of insulin receptor substrate (IRS)-1 and IRS-2.

    Araujo EP, Amaral ME, Filiputti E, De Souza CT, Laurito TL, Augusto VD, Saad MJ, Boschero AC, Velloso LA, Carneiro EM.

    J Endocrinol. 2004 Apr;181(1):25-38.PMID: 15072564 [PubMed - indexed for MEDLINE]Related articlesFree article

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