PubMed

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes.

Chentoufi AA, Polychronakos C.

Diabetes. 2002 May;51(5):1383-90. Erratum in: Diabetes 2002 Aug;51(8):2665. PMID: 11978634 [PubMed - indexed for MEDLINE]Related articlesFree article

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.

Vafiadis P, Ounissi-Benkalha H, Palumbo M, Grabs R, Rousseau M, Goodyer CG, Polychronakos C.

J Clin Endocrinol Metab. 2001 Aug;86(8):3705-10.PMID: 11502799 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, Wickramasinghe S, Colle E, Polychronakos C.

Nat Genet. 1997 Mar;15(3):289-92.PMID: 9054944 [PubMed - indexed for MEDLINE]Related articles

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

Pugliese A, Zeller M, Fernandez A Jr, Zalcberg LJ, Bartlett RJ, Ricordi C, Pietropaolo M, Eisenbarth GS, Bennett ST, Patel DD.

Nat Genet. 1997 Mar;15(3):293-7.PMID: 9054945 [PubMed - indexed for MEDLINE]Related articles

Thymus-specific deletion of insulin induces autoimmune diabetes.

Fan Y, Rudert WA, Grupillo M, He J, Sisino G, Trucco M.

EMBO J. 2009 Sep 16;28(18):2812-24. Epub 2009 Aug 13.PMID: 19680229 [PubMed - indexed for MEDLINE]Related articles

Autoimmune responses to the beta cell autoantigen, insulin, and the INS VNTR-IDDM2 locus.

Sarugeri E, Dozio N, Belloni C, Meschi F, Pastore MR, Bonifacio E.

Clin Exp Immunol. 1998 Dec;114(3):370-6.PMID: 9844045 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance.

Smith KM, Olson DC, Hirose R, Hanahan D.

Int Immunol. 1997 Sep;9(9):1355-65.PMID: 9310839 [PubMed - indexed for MEDLINE]Related articlesFree article

Advances in type I diabetes associated tolerance mechanisms.

Chentoufi AA, Binder NR, Berka N, Abunadi T, Polychronakos C.

Scand J Immunol. 2008 Jul;68(1):1-11. Epub 2008 May 9. Review.PMID: 18482207 [PubMed - indexed for MEDLINE]Related articles

Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.

Vafiadis P, Bennett ST, Todd JA, Grabs R, Polychronakos C.

J Clin Endocrinol Metab. 1998 Aug;83(8):2933-9.PMID: 9709972 [PubMed - indexed for MEDLINE]Related articlesFree article

Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes.

Kecha-Kamoun O, Achour I, Martens H, Collette J, Lefebvre PJ, Greiner DL, Geenen V.

Diabetes Metab Res Rev. 2001 Mar-Apr;17(2):146-52.PMID: 11307180 [PubMed - indexed for MEDLINE]Related articles

Tolerance to proinsulin-2 is due to radioresistant thymic cells.

Faideau B, Lotton C, Lucas B, Tardivel I, Elliott JF, Boitard C, Carel JC.

J Immunol. 2006 Jul 1;177(1):53-60.PMID: 16785498 [PubMed - indexed for MEDLINE]Related articlesFree article

In a transgenic model of spontaneous autoimmune diabetes, expression of a protective class II MHC molecule results in thymic deletion of diabetogenic CD8+ T cells.

Morgan DJ, Nugent CT, Raveney BJ, Sherman LA.

J Immunol. 2004 Jan 15;172(2):1000-8.PMID: 14707073 [PubMed - indexed for MEDLINE]Related articlesFree article

Class III alleles at the insulin VNTR polymorphism are associated with regulatory T-cell responses to proinsulin epitopes in HLA-DR4, DQ8 individuals.

Durinovic-Belló I, Jelinek E, Schlosser M, Eiermann T, Boehm BO, Karges W, Marchand L, Polychronakos C.

Diabetes. 2005 Dec;54 Suppl 2:S18-24.PMID: 16306335 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin expression in the thymus, tolerance, and type 1 diabetes.

Pugliese A.

Diabetes Metab Rev. 1998 Dec;14(4):325-7. No abstract available. PMID: 10096001 [PubMed - indexed for MEDLINE]Related articles

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes.

Jaeckel E, Lipes MA, von Boehmer H.

Nat Immunol. 2004 Oct;5(10):1028-35. Epub 2004 Sep 19. Erratum in: Nat Immunol. 2004 Nov;5(11):1190. Nat Immunol. 2005 Feb;6(2):219. PMID: 15378058 [PubMed - indexed for MEDLINE]Related articles

IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.

Alba A, Puertas MC, Carrillo J, Planas R, Ampudia R, Pastor X, Bosch F, Pujol-Borrell R, Verdaguer J, Vives-Pi M.

J Immunol. 2004 Dec 1;173(11):6667-75.PMID: 15557158 [PubMed - indexed for MEDLINE]Related articlesFree article

No association of INS-VNTR genotype and IAA autoantibodies.

Pérez de Nanclares G, Bilbao JR, Castano L.

Ann N Y Acad Sci. 2004 Dec;1037:127-30.PMID: 15699505 [PubMed - indexed for MEDLINE]Related articles

Evidence for de novo expression of thymic insulin by peripheral bone marrow-derived cells.

Carlsén M, Cilio CM.

Scand J Immunol. 2008 Jul;68(1):67-74. Epub 2008 May 13.PMID: 18482204 [PubMed - indexed for MEDLINE]Related articles

Proinsulin expression by Hassall's corpuscles in the mouse thymus.

Chentoufi AA, Palumbo M, Polychronakos C.

Diabetes. 2004 Feb;53(2):354-9.PMID: 14747285 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice.

Karges W, Pechhold K, Al Dahouk S, Riegger I, Rief M, Wissmann A, Schirmbeck R, Barth C, Boehm BO.

Diabetes. 2002 Nov;51(11):3237-44.PMID: 12401715 [PubMed - indexed for MEDLINE]Related articlesFree article