PubMed

Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.

Graham J, Hagopian WA, Kockum I, Li LS, Sanjeevi CB, Lowe RM, Schaefer JB, Zarghami M, Day HL, Landin-Olsson M, Palmer JP, Janer-Villanueva M, Hood L, Sundkvist G, Lernmark A, Breslow N, Dahlquist G, Blohmé G; Diabetes Incidence in Sweden Study Group; Swedish Childhood Diabetes Study Group.

Diabetes. 2002 May;51(5):1346-55.PMID: 11978629 [PubMed - indexed for MEDLINE]Related articlesFree article

IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.

Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, Barratt BJ, Todd JA, Ziegler AG, Bonifacio E.

Diabetologia. 2003 May;46(5):712-20. Epub 2003 May 16.PMID: 12750767 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: association with IA-2 and islet cell autoantibodies.

Winnock F, Christie MR, Batstra MR, Aanstoot HJ, Weets I, Decochez K, Jopart P, Nicolaij D, Gorus FK; Belgian Diabetes Registry.

Diabetes Care. 2001 Jul;24(7):1181-6.PMID: 11423499 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic susceptibility for insulin-dependent diabetes mellitus in Caucasians revisited: the importance of diabetes registries in disclosing interactions between HLA-DQ- and insulin gene-linked risk. Belgian Diabetes Registry.

van der Auwera B, Schuit F, Lyaruu I, Falorni A, Svanholm S, Vandewalle CL, Gorus FK.

J Clin Endocrinol Metab. 1995 Sep;80(9):2567-73.PMID: 7673396 [PubMed - indexed for MEDLINE]Related articles

Associations of GAD65- and IA-2- autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. The Belgian Diabetes Registry.

Vandewalle CL, Falorni A, Lernmark A, Goubert P, Dorchy H, Coucke W, Semakula C, Van der Auwera B, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK.

Diabetes Care. 1997 Oct;20(10):1547-52.PMID: 9314633 [PubMed - indexed for MEDLINE]Related articles

CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry.

Van der Auwera BJ, Vandewalle CL, Schuit FC, Winnock F, De Leeuw IH, Van Imschoot S, Lamberigts G, Gorus FK.

Clin Exp Immunol. 1997 Oct;110(1):98-103.PMID: 9353155 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes.

Decochez K, Truyen I, van der Auwera B, Weets I, Vandemeulebroucke E, de Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2005 Apr;48(4):687-94. Epub 2005 Mar 9.PMID: 15756536 [PubMed - indexed for MEDLINE]Related articles

Risk of type 1 diabetes development in children with incidental hyperglycemia: A multicenter Italian study.

Lorini R, Alibrandi A, Vitali L, Klersy C, Martinetti M, Betterle C, d'Annunzio G, Bonifacio E; Pediatric Italian Study Group of Prediabetes.

Diabetes Care. 2001 Jul;24(7):1210-6.PMID: 11423504 [PubMed - indexed for MEDLINE]Related articlesFree article

Progression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high-risk haplotypes.

Pietropaolo M, Becker DJ, LaPorte RE, Dorman JS, Riboni S, Rudert WA, Mazumdar S, Trucco M.

Diabetologia. 2002 Jan;45(1):66-76.PMID: 11845225 [PubMed - indexed for MEDLINE]Related articles

Insulin VNTR I/III genotype is associated with autoantibodies against glutamic acid decarboxylase in newly diagnosed type 1 diabetes.

Rajasalu T, Haller K, Salur L, Kisand K, Tillmann V, Schlosser M, Uibo R.

Diabetes Metab Res Rev. 2007 Oct;23(7):567-71.PMID: 17461431 [PubMed - indexed for MEDLINE]Related articles

Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQA1*0301-DQB1*0302 haplotype at clinical type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40 years. The Belgian Diabetes Registry.

Vandewalle CL, Decraene T, Schuit FC, De Leeuw IH, Pipeleers DG, Gorus FK.

Diabetologia. 1993 Nov;36(11):1155-62.PMID: 8270130 [PubMed - indexed for MEDLINE]Related articles

Genetic risk determines the emergence of diabetes-associated autoantibodies in young children.

Kupila A, Keskinen P, Simell T, Erkkilä S, Arvilommi P, Korhonen S, Kimpimäki T, Sjöroos M, Ronkainen M, Ilonen J, Knip M, Simell O.

Diabetes. 2002 Mar;51(3):646-51.PMID: 11872662 [PubMed - indexed for MEDLINE]Related articlesFree article

Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence.

Weets I, Kaufman L, Van der Auwera B, Crenier L, Rooman RP, De Block C, Casteels K, Weber E, Coeckelberghs M, Laron Z, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2004 Apr;47(4):614-21.PMID: 15298337 [PubMed - indexed for MEDLINE]Related articles

Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodies.

Robles DT, Eisenbarth GS, Wang T, Erlich HA, Bugawan TL, Babu SR, Barriga K, Norris JM, Hoffman M, Klingensmith G, Yu L, Rewers M; Diabetes Autoimmunity Study in the Young.

Clin Immunol. 2002 Mar;102(3):217-24.PMID: 11890708 [PubMed - indexed for MEDLINE]Related articles

Detection of autoantibodies against islet amyloid polypeptide in human serum. Lack of association with type 1 (insulin-dependent) diabetes mellitus, or with conditions favouring amyloid deposition in islets. The Belgian Diabetes Registry.

Gorus FK, Sodoyez JC, Pipeleers DG, Keymeulen B, Foriers A, Van Schravendijk CF.

Diabetologia. 1992 Nov;35(11):1080-6.PMID: 1473619 [PubMed - indexed for MEDLINE]Related articles

Homozygosity for premature stop codon of the MHC class I chain-related gene A (MIC-A) is associated with early activation of islet autoimmunity of DR3/4-DQ2/8 high risk DAISY relatives.

Ide A, Babu SR, Robles DT, Wang T, Erlich HA, Bugawan TL, Rewers M, Fain PR, Eisenbarth GS.

J Clin Immunol. 2005 Jul;25(4):303-8.PMID: 16133985 [PubMed - indexed for MEDLINE]Related articles

Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies.

Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E.

JAMA. 2003 Oct 1;290(13):1721-8.PMID: 14519706 [PubMed - indexed for MEDLINE]Related articlesFree article

Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?

Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth GS, Norris JM, Rewers MJ.

Diabetes. 2009 Apr;58(4):1028-33. Epub 2009 Feb 2.PMID: 19188433 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes.

Redondo MJ, Babu S, Zeidler A, Orban T, Yu L, Greenbaum C, Palmer JP, Cuthbertson D, Eisenbarth GS, Krischer JP, Schatz D; Diabetes Prevention Trial Type 1 Study Group.

J Clin Endocrinol Metab. 2006 May;91(5):1705-13. Epub 2006 Feb 7.PMID: 16464953 [PubMed - indexed for MEDLINE]Related articlesFree article

Geographical variation in risk HLA-DQB1 genotypes for type 1 diabetes and signs of beta-cell autoimmunity in a high-incidence country.

Kukko M, Virtanen SM, Toivonen A, Simell S, Korhonen S, Ilonen J, Simel O, Knip M.

Diabetes Care. 2004 Mar;27(3):676-81.PMID: 14988284 [PubMed - indexed for MEDLINE]Related articlesFree article