PubMed

A new delivery system for 5-fluorouracil using prodrug and converting enzyme.

Akimoto M, Miyahara T, Arai J, Akimoto A, Hamada H, Yoshida Y, Yoshimura N.

Br J Ophthalmol. 2002 May;86(5):581-6.PMID: 11973258 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: a potential purging method for autologous transplantation.

Garcia-Sanchez F, Pizzorno G, Fu SQ, Nanakorn T, Krause DS, Liang J, Adams E, Leffert JJ, Yin LH, Cooperberg MR, Hanania E, Wang WL, Won JH, Peng XY, Cote R, Brown R, Burtness B, Giles R, Crystal R, Deisseroth AB.

Blood. 1998 Jul 15;92(2):672-82.PMID: 9657770 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo.

Pederson LC, Buchsbaum DJ, Vickers SM, Kancharla SR, Mayo MS, Curiel DT, Stackhouse MA.

Cancer Res. 1997 Oct 1;57(19):4325-32.PMID: 9331094 [PubMed - indexed for MEDLINE]Related articlesFree article

Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas.

Miller CR, Williams CR, Buchsbaum DJ, Gillespie GY.

Cancer Res. 2002 Feb 1;62(3):773-80.PMID: 11830532 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytosine deaminase-producing human mesenchymal stem cells mediate an antitumor effect in a mouse xenograft model.

You MH, Kim WJ, Shim W, Lee SR, Lee G, Choi S, Kim DY, Kim YM, Kim H, Han SU.

J Gastroenterol Hepatol. 2009 Aug;24(8):1393-400. Epub 2009 May 28.PMID: 19486256 [PubMed - indexed for MEDLINE]Related articles

Selective in vivo radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells transduced with the E. coli cytosine deaminase (CD) gene.

Gabel M, Kim JH, Kolozsvary A, Khil M, Freytag S.

Int J Radiat Oncol Biol Phys. 1998 Jul 1;41(4):883-7.PMID: 9652853 [PubMed - indexed for MEDLINE]Related articles

Adenovirus mediated cytosine deaminase gene transduction and 5-fluorocytosine therapy sensitizes mouse prostate cancer cells to irradiation.

Anello R, Cohen S, Atkinson G, Hall SJ.

J Urol. 2000 Dec;164(6):2173-7.PMID: 11061950 [PubMed - indexed for MEDLINE]Related articles

Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts.

Kievit E, Nyati MK, Ng E, Stegman LD, Parsels J, Ross BD, Rehemtulla A, Lawrence TS.

Cancer Res. 2000 Dec 1;60(23):6649-55.PMID: 11118048 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase.

Chung-Faye GA, Chen MJ, Green NK, Burton A, Anderson D, Mautner V, Searle PF, Kerr DJ.

Gene Ther. 2001 Oct;8(20):1547-54.PMID: 11704815 [PubMed - indexed for MEDLINE]Related articlesFree article

Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models.

Stackhouse MA, Pederson LC, Grizzle WE, Curiel DT, Gebert J, Haack K, Vickers SM, Mayo MS, Buchsbaum DJ.

Gene Ther. 2000 Jun;7(12):1019-26.PMID: 10871750 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined radiation and enzyme/prodrug treatment for head and neck cancer in an orthotopic animal model.

Hamstra DA, Rice DJ, Pu A, Oyedijo D, Ross BD, Rehemtulla A.

Radiat Res. 1999 Nov;152(5):499-507.PMID: 10521927 [PubMed - indexed for MEDLINE]Related articles

Bystander effect caused by cytosine deaminase gene and 5-fluorocytosine in vitro is substantially mediated by generated 5-fluorouracil.

Kuriyama S, Masui K, Sakamoto T, Nakatani T, Kikukawa M, Tsujinoue H, Mitoro A, Yamazaki M, Yoshiji H, Fukui H, Ikenaka K, Mullen CA, Tsujii T.

Anticancer Res. 1998 Sep-Oct;18(5A):3399-406.PMID: 9858915 [PubMed - indexed for MEDLINE]Related articles

Evaluation of the acute and subchronic toxic effects in mice, rats, and monkeys of the genetically engineered and Escherichia coli cytosine deaminase gene-incorporated Salmonella strain, TAPET-CD, being developed as an antitumor agent.

Lee KC, Zheng LM, Margitich D, Almassian B, King I.

Int J Toxicol. 2001 Jul-Aug;20(4):207-17.PMID: 11563416 [PubMed - indexed for MEDLINE]Related articles

The potential therapeutic gain of radiation-associated gene therapy with the suicide gene cytosine deaminase.

Lambin P, Nuyts S, Landuyt W, Theys J, De Bruijn E, Anné J, Van Mellaert L, Fowler J.

Int J Radiat Biol. 2000 Mar;76(3):285-93.PMID: 10757308 [PubMed - indexed for MEDLINE]Related articles

Monitoring gene therapy with cytosine deaminase: in vitro studies using tritiated-5-fluorocytosine.

Haberkorn U, Oberdorfer F, Gebert J, Morr I, Haack K, Weber K, Lindauer M, van Kaick G, Schackert HK.

J Nucl Med. 1996 Jan;37(1):87-94.PMID: 8544010 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined cytosine deaminase expression, 5-fluorocytosine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells.

Pederson LC, Vickers SM, Buchsbaum DJ, Kancharla SR, Mayo MS, Curiel DT, Stackhouse MA.

J Gastrointest Surg. 1998 May-Jun;2(3):283-91.PMID: 9841986 [PubMed - indexed for MEDLINE]Related articles

Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine.

Wallace PM, MacMaster JF, Smith VF, Kerr DE, Senter PD, Cosand WL.

Cancer Res. 1994 May 15;54(10):2719-23.PMID: 8168103 [PubMed - indexed for MEDLINE]Related articlesFree article

Antitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminase.

Park JI, Cao L, Platt VM, Huang Z, Stull RA, Dy EE, Sperinde JJ, Yokoyama JS, Szoka FC.

Mol Pharm. 2009 May-Jun;6(3):801-12.PMID: 19265397 [PubMed - indexed for MEDLINE]Related articles

Potential benefits of combining cytosine deaminase/5-fluorocytosine gene therapy and irradiation for prostate cancer: experimental study.

Kato H, Koshida K, Yokoyama K, Mizokami A, Namiki M.

Int J Urol. 2002 Oct;9(10):567-76.PMID: 12445236 [PubMed - indexed for MEDLINE]Related articles

Synergistic effect of electric pulses and bleomycin on cultured rabbit subconjunctival fibroblasts.

Oshima Y, Sakamoto T, Kawano Y, Hata Y, Yoshikawa H, Sonoda KH, Ishibashi T, Inomata H.

Graefes Arch Clin Exp Ophthalmol. 1998 Jan;236(1):52-60.PMID: 9457517 [PubMed - indexed for MEDLINE]Related articles