PubMed

Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy.

Trost SU, Belke DD, Bluhm WF, Meyer M, Swanson E, Dillmann WH.

Diabetes. 2002 Apr;51(4):1166-71.PMID: 11916940 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic rat hearts overexpressing SERCA2a show improved contractility under baseline conditions and pressure overload.

Müller OJ, Lange M, Rattunde H, Lorenzen HP, Müller M, Frey N, Bittner C, Simonides W, Katus HA, Franz WM.

Cardiovasc Res. 2003 Aug 1;59(2):380-9.PMID: 12909321 [PubMed - indexed for MEDLINE]Related articlesFree article

Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy.

Suarez J, Scott B, Dillmann WH.

Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1439-45. Epub 2008 Sep 17.PMID: 18799637 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of sarcoplasmic reticulum Ca(2+)-ATPase improves cardiac contractile function in hypothyroid mice.

Bluhm WF, Meyer M, Sayen MR, Swanson EA, Dillmann WH.

Cardiovasc Res. 1999 Aug 1;43(2):382-8.PMID: 10536668 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased SR Ca2+ cycling contributes to improved contractile performance in SERCA2a-overexpressing transgenic rats.

Maier LS, Wahl-Schott C, Horn W, Weichert S, Pagel C, Wagner S, Dybkova N, Müller OJ, Näbauer M, Franz WM, Pieske B.

Cardiovasc Res. 2005 Sep 1;67(4):636-46.PMID: 15932750 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts.

Vetter R, Rehfeld U, Reissfelder C, Weiss W, Wagner KD, Günther J, Hammes A, Tschöpe C, Dillmann W, Paul M.

FASEB J. 2002 Oct;16(12):1657-9. Epub 2002 Aug 21.PMID: 12206992 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts.

Baker DL, Hashimoto K, Grupp IL, Ji Y, Reed T, Loukianov E, Grupp G, Bhagwhat A, Hoit B, Walsh R, Marban E, Periasamy M.

Circ Res. 1998 Dec 14-28;83(12):1205-14.PMID: 9851937 [PubMed - indexed for MEDLINE]Related articlesFree article

Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase.

Schmidt U, del Monte F, Miyamoto MI, Matsui T, Gwathmey JK, Rosenzweig A, Hajjar RJ.

Circulation. 2000 Feb 22;101(7):790-6.PMID: 10683354 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure.

Miyamoto MI, del Monte F, Schmidt U, DiSalvo TS, Kang ZB, Matsui T, Guerrero JL, Gwathmey JK, Rosenzweig A, Hajjar RJ.

Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):793-8.PMID: 10639159 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice.

Asahi M, Otsu K, Nakayama H, Hikoso S, Takeda T, Gramolini AO, Trivieri MG, Oudit GY, Morita T, Kusakari Y, Hirano S, Hongo K, Hirotani S, Yamaguchi O, Peterson A, Backx PH, Kurihara S, Hori M, MacLennan DH.

Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9199-204. Epub 2004 Jun 16.PMID: 15201433 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered calcium handling is an early sign of streptozotocin-induced diabetic cardiomyopathy.

Ligeti L, Szenczi O, Prestia CM, Szabó C, Horváth K, Marcsek ZL, van Stiphout RG, van Riel NA, Op den Buijs J, Van der Vusse GJ, Ivanics T.

Int J Mol Med. 2006 Jun;17(6):1035-43.PMID: 16685413 [PubMed - indexed for MEDLINE]Related articles

Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.

Ver Heyen M, Heymans S, Antoons G, Reed T, Periasamy M, Awede B, Lebacq J, Vangheluwe P, Dewerchin M, Collen D, Sipido K, Carmeliet P, Wuytack F.

Circ Res. 2001 Oct 26;89(9):838-46.PMID: 11679415 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart.

Belke DD, Swanson EA, Dillmann WH.

Diabetes. 2004 Dec;53(12):3201-8.PMID: 15561951 [PubMed - indexed for MEDLINE]Related articlesFree article

Doxycycline inducible expression of SERCA2a improves calcium handling and reverts cardiac dysfunction in pressure overload-induced cardiac hypertrophy.

Suarez J, Gloss B, Belke DD, Hu Y, Scott B, Dieterle T, Kim YK, Valencik ML, McDonald JA, Dillmann WH.

Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2164-72. Epub 2004 Jul 15.PMID: 15256372 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of SERCA2b in the heart leads to an increase in sarcoplasmic reticulum calcium transport function and increased cardiac contractility.

Greene AL, Lalli MJ, Ji Y, Babu GJ, Grupp I, Sussman M, Periasamy M.

J Biol Chem. 2000 Aug 11;275(32):24722-7.PMID: 10816568 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation.

He H, Giordano FJ, Hilal-Dandan R, Choi DJ, Rockman HA, McDonough PM, Bluhm WF, Meyer M, Sayen MR, Swanson E, Dillmann WH.

J Clin Invest. 1997 Jul 15;100(2):380-9.PMID: 9218515 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired sarcoplasmic reticulum function leads to contractile dysfunction and cardiac hypertrophy.

Meyer M, Trost SU, Bluhm WF, Knot HJ, Swanson E, Dillmann WH.

Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2046-52.PMID: 11299205 [PubMed - indexed for MEDLINE]Related articlesFree article

SERCA overexpression reduces hydroxyl radical injury in murine myocardium.

Hiranandani N, Bupha-Intr T, Janssen PM.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3130-5. Epub 2006 Jun 23.PMID: 16798816 [PubMed - indexed for MEDLINE]Related articlesFree article

Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.

Zheng M, Dilly K, Dos Santos Cruz J, Li M, Gu Y, Ursitti JA, Chen J, Ross J Jr, Chien KR, Lederer JW, Wang Y.

Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H424-33. Epub 2003 Sep 11.PMID: 12969887 [PubMed - indexed for MEDLINE]Related articlesFree article

Lusitropic effect of MCC-135 is associated with improvement of sarcoplasmic reticulum function in ventricular muscles of rats with diabetic cardiomyopathy.

Satoh N, Sato T, Shimada M, Yamada K, Kitada Y.

J Pharmacol Exp Ther. 2001 Sep;298(3):1161-6.PMID: 11504815 [PubMed - indexed for MEDLINE]Related articlesFree article