PubMed

Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome.

Whorwood CB, Donovan SJ, Flanagan D, Phillips DI, Byrne CD.

Diabetes. 2002 Apr;51(4):1066-75.PMID: 11916927 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of glucocorticoid receptor alpha and beta isoforms and type I 11beta-hydroxysteroid dehydrogenase expression in human skeletal muscle cells: a key role in the pathogenesis of insulin resistance?

Whorwood CB, Donovan SJ, Wood PJ, Phillips DI.

J Clin Endocrinol Metab. 2001 May;86(5):2296-308.PMID: 11344242 [PubMed - indexed for MEDLINE]Related articlesFree article

Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11beta-hydroxysteroid dehydrogenase type 1) gene.

Iwasaki Y, Takayasu S, Nishiyama M, Tsugita M, Taguchi T, Asai M, Yoshida M, Kambayashi M, Hashimoto K.

Mol Cell Endocrinol. 2008 Mar 26;285(1-2):10-8. Epub 2008 Feb 2.PMID: 18313835 [PubMed - indexed for MEDLINE]Related articles

Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice.

Liu Y, Nakagawa Y, Wang Y, Sakurai R, Tripathi PV, Lutfy K, Friedman TC.

Diabetes. 2005 Jan;54(1):32-40.PMID: 15616008 [PubMed - indexed for MEDLINE]Related articlesFree article

11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle.

Nair S, Lee YH, Lindsay RS, Walker BR, Tataranni PA, Bogardus C, Baier LJ, Permana PA.

Diabetologia. 2004 Jun;47(6):1088-95. Epub 2004 May 20.PMID: 15156315 [PubMed - indexed for MEDLINE]Related articles

Effect of voluntary exercise on peripheral tissue glucocorticoid receptor content and the expression and activity of 11beta-HSD1 in the Syrian hamster.

Coutinho AE, Campbell JE, Fediuc S, Riddell MC.

J Appl Physiol. 2006 May;100(5):1483-8. Epub 2005 Dec 15.PMID: 16357069 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins.

Kannisto K, Pietiläinen KH, Ehrenborg E, Rissanen A, Kaprio J, Hamsten A, Yki-Järvinen H.

J Clin Endocrinol Metab. 2004 Sep;89(9):4414-21.PMID: 15356040 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome.

Masuzaki H, Flier JS.

Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):255-62. Review.PMID: 14683456 [PubMed - indexed for MEDLINE]Related articles

Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates.

Tsilchorozidou T, Honour JW, Conway GS.

J Clin Endocrinol Metab. 2003 Dec;88(12):5907-13.PMID: 14671189 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased expression of 11beta-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubes.

Abdallah BM, Beck-Nielsen H, Gaster M.

Eur J Clin Invest. 2005 Oct;35(10):627-34.PMID: 16178882 [PubMed - indexed for MEDLINE]Related articles

Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.

Tomlinson JW, Finney J, Gay C, Hughes BA, Hughes SV, Stewart PM.

Diabetes. 2008 Oct;57(10):2652-60. Epub 2008 Jul 15.PMID: 18633104 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men.

Wake DJ, Stimson RH, Tan GD, Homer NZ, Andrew R, Karpe F, Walker BR.

J Clin Endocrinol Metab. 2007 May;92(5):1848-56. Epub 2007 Feb 27.PMID: 17327378 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice.

Liu Y, Nakagawa Y, Wang Y, Liu L, Du H, Wang W, Ren X, Lutfy K, Friedman TC.

J Mol Endocrinol. 2008 Aug;41(2):53-64. Epub 2008 Jun 4.PMID: 18524870 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects.

Alberti L, Girola A, Gilardini L, Conti A, Cattaldo S, Micheletto G, Invitti C.

Int J Obes (Lond). 2007 Dec;31(12):1826-31. Epub 2007 Jun 26.PMID: 17593901 [PubMed - indexed for MEDLINE]Related articles

Growth hormone, insulin-like growth factor-I and the cortisol-cortisone shuttle.

Stewart PM, Toogood AA, Tomlinson JW.

Horm Res. 2001;56 Suppl 1:1-6. Review.PMID: 11786677 [PubMed - indexed for MEDLINE]Related articles

Altered activity of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes.

Jang C, Obeyesekere VR, Dilley RJ, Krozowski Z, Inder WJ, Alford FP.

J Clin Endocrinol Metab. 2007 Aug;92(8):3314-20. Epub 2007 May 22.PMID: 17519316 [PubMed - indexed for MEDLINE]Related articlesFree article

Local and systemic impact of transcriptional up-regulation of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity.

Wake DJ, Rask E, Livingstone DE, Söderberg S, Olsson T, Walker BR.

J Clin Endocrinol Metab. 2003 Aug;88(8):3983-8.PMID: 12915696 [PubMed - indexed for MEDLINE]Related articlesFree article

11beta-hydroxysteroid dehydrogenase type 1 and obesity.

Morton NM, Seckl JR.

Front Horm Res. 2008;36:146-64. Review.PMID: 18230901 [PubMed - indexed for MEDLINE]Related articles

Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity.

Michailidou Z, Jensen MD, Dumesic DA, Chapman KE, Seckl JR, Walker BR, Morton NM.

Obesity (Silver Spring). 2007 May;15(5):1155-63.PMID: 17495191 [PubMed - indexed for MEDLINE]Related articles

Osteoblastic 11beta-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure.

Cooper MS, Rabbitt EH, Goddard PE, Bartlett WA, Hewison M, Stewart PM.

J Bone Miner Res. 2002 Jun;17(6):979-86.PMID: 12054173 [PubMed - indexed for MEDLINE]Related articles