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    Results: 1 to 20 of 119

    1.

    Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function.

    Busch AK, Cordery D, Denyer GS, Biden TJ.

    Diabetes. 2002 Apr;51(4):977-87.PMID: 11916915 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Effects of fatty acid regulation on visfatin gene expression in adipocytes.

    Wen Y, Wang HW, Wu J, Lu HL, Hu XF, Cianflone K.

    Chin Med J (Engl). 2006 Oct 20;119(20):1701-8.PMID: 17097017 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1.

    Roche E, Buteau J, Aniento I, Reig JA, Soria B, Prentki M.

    Diabetes. 1999 Oct;48(10):2007-14.PMID: 10512366 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis.

    Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A.

    Endocrinology. 2006 Jul;147(7):3398-407. Epub 2006 Apr 6.PMID: 16601139 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.

    Collins SC, Salehi A, Eliasson L, Olofsson CS, Rorsman P.

    Diabetologia. 2008 Sep;51(9):1689-93. Epub 2008 Jul 12.PMID: 18622593 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1.

    Brun T, Assimacopoulos-Jeannet F, Corkey BE, Prentki M.

    Diabetes. 1997 Mar;46(3):393-400.PMID: 9032094 [PubMed - indexed for MEDLINE]Related articles

    7.

    Beneficial effects of lipids and prolactin on insulin secretion and beta-cell proliferation: a role for lipids in the adaptation of islets to pregnancy.

    Brelje TC, Bhagroo NV, Stout LE, Sorenson RL.

    J Endocrinol. 2008 May;197(2):265-76.PMID: 18434356 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate.

    Ritz-Laser B, Meda P, Constant I, Klages N, Charollais A, Morales A, Magnan C, Ktorza A, Philippe J.

    Endocrinology. 1999 Sep;140(9):4005-14.PMID: 10465270 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.

    Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY.

    Diabetes. 2003 Mar;52(3):726-33.PMID: 12606514 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

    Zhou YP, Grill VE.

    J Clin Invest. 1994 Feb;93(2):870-6.PMID: 8113418 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells.

    Bollheimer LC, Kemptner DM, Kagerbauer SM, Kestler TM, Wrede CE, Buettner R.

    Eur J Endocrinol. 2003 Apr;148(4):481-6.PMID: 12656670 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

    Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

    Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Regulation of insulin secretion and expression of SUR1 gene by chronic exposure to free fatty acids in rat pancreatic beta cells.

    Yuan L, Deng X, Chen L, Zhou M.

    J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):358-60, 364.PMID: 15587398 [PubMed - indexed for MEDLINE]Related articles

    14.

    Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics.

    Biden TJ, Robinson D, Cordery D, Hughes WE, Busch AK.

    Diabetes. 2004 Feb;53 Suppl 1:S159-65. Review.PMID: 14749282 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    The antiepileptic drug topiramate preserves metabolism-secretion coupling in insulin secreting cells chronically exposed to the fatty acid oleate.

    Frigerio F, Chaffard G, Berwaer M, Maechler P.

    Biochem Pharmacol. 2006 Oct 16;72(8):965-73. Epub 2006 Aug 28.PMID: 16934763 [PubMed - indexed for MEDLINE]Related articles

    16.

    Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

    Busch AK, Gurisik E, Cordery DV, Sudlow M, Denyer GS, Laybutt DR, Hughes WE, Biden TJ.

    Diabetes. 2005 Oct;54(10):2917-24.PMID: 16186393 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Differential impact of acute and chronic lipotoxicity on gene expression in INS-1 cells.

    Xiao J, Gregersen S, Pedersen SB, Hermansen K.

    Metabolism. 2002 Feb;51(2):155-62.PMID: 11833041 [PubMed - indexed for MEDLINE]Related articles

    18.

    Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.

    Wang X, Li H, De Leo D, Guo W, Koshkin V, Fantus IG, Giacca A, Chan CB, Der S, Wheeler MB.

    Diabetes. 2004 Jan;53(1):129-40.PMID: 14693707 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Oleate regulates genes controlled by signaling pathways of mitogen-activated protein kinase, insulin, and hypoxia.

    Vock C, Gleissner M, Klapper M, Döring F.

    Nutr Res. 2008 Oct;28(10):681-9.PMID: 19083476 [PubMed - indexed for MEDLINE]Related articles

    20.

    Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells.

    Ishihara H, Nakazaki M, Kanegae Y, Inukai K, Asano T, Katagiri H, Yazaki Y, Kikuchi M, Miyazaki J, Saito I, Oka Y.

    Diabetes. 1996 Sep;45(9):1238-44.PMID: 8772729 [PubMed - indexed for MEDLINE]Related articles

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