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    Results: 1 to 20 of 1474

    1.

    Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.

    Lingohr MK, Dickson LM, McCuaig JF, Hugl SR, Twardzik DR, Rhodes CJ.

    Diabetes. 2002 Apr;51(4):966-76.PMID: 11916914 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

    Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, Kahn BB, Myers MG Jr, Rhodes CJ.

    J Biol Chem. 2001 Jun 15;276(24):21110-20. Epub 2001 Mar 27.PMID: 11274216 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.

    Cousin SP, Hügl SR, Myers MG Jr, White MF, Reifel-Miller A, Rhodes CJ.

    Biochem J. 1999 Dec 15;344 Pt 3:649-58.PMID: 10585851 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.

    Annerén C, Welsh M.

    Mol Med. 2002 Nov;8(11):705-13.PMID: 12520087 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.

    Cousin SP, Hügl SR, Wrede CE, Kajio H, Myers MG Jr, Rhodes CJ.

    Endocrinology. 2001 Jan;142(1):229-40.PMID: 11145586 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

    Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.

    J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.PMID: 12970360 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).

    Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ.

    J Mol Endocrinol. 2003 Jun;30(3):271-86.PMID: 12790799 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Stimulation of insulin-like growth factor (IGF) binding protein-3 synthesis by IGF-I and transforming growth factor-alpha is mediated by both phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways in mammary epithelial cells.

    Sivaprasad U, Fleming J, Verma PS, Hogan KA, Desury G, Cohick WS.

    Endocrinology. 2004 Sep;145(9):4213-21. Epub 2004 Jun 10.PMID: 15192040 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells.

    Bartucci M, Morelli C, Mauro L, Andò S, Surmacz E.

    Cancer Res. 2001 Sep 15;61(18):6747-54.PMID: 11559546 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway.

    Kurihara S, Hakuno F, Takahashi S.

    Endocr J. 2000 Dec;47(6):739-51.PMID: 11228049 [PubMed - indexed for MEDLINE]Related articles

    11.

    Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.

    Thimmaiah KN, Easton J, Huang S, Veverka KA, Germain GS, Harwood FC, Houghton PJ.

    Cancer Res. 2003 Jan 15;63(2):364-74.PMID: 12543789 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.

    Hügl SR, White MF, Rhodes CJ.

    J Biol Chem. 1998 Jul 10;273(28):17771-9.PMID: 9651378 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins.

    Welsh N, Makeeva N, Welsh M.

    Mol Med. 2002 Nov;8(11):695-704.PMID: 12520086 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Growth factor-specific regulation of insulin receptor substrate-1 expression in MCF-7 breast carcinoma cells: effects on the insulin-like growth factor signaling pathway.

    Lassarre C, Ricort JM.

    Endocrinology. 2003 Nov;144(11):4811-9. Epub 2003 Jul 24.PMID: 12960057 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells.

    Halevy O, Cantley LC.

    Exp Cell Res. 2004 Jul 1;297(1):224-34.PMID: 15194438 [PubMed - indexed for MEDLINE]Related articles

    16.

    Transforming growth factor-alpha and epidermal growth factor activate mitogen-activated protein kinase and its substrates in intestinal epithelial cells.

    Oliver BL, Sha'afi RI, Hajjar JJ.

    Proc Soc Exp Biol Med. 1995 Nov;210(2):162-70.PMID: 7568287 [PubMed - indexed for MEDLINE]Related articles

    17.

    Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells.

    Andreozzi F, Laratta E, Sciacqua A, Perticone F, Sesti G.

    Circ Res. 2004 May 14;94(9):1211-8. Epub 2004 Mar 25.PMID: 15044323 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.

    Mehrhof FB, Müller FU, Bergmann MW, Li P, Wang Y, Schmitz W, Dietz R, von Harsdorf R.

    Circulation. 2001 Oct 23;104(17):2088-94.PMID: 11673351 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.

    Kim B, Cheng HL, Margolis B, Feldman EL.

    J Biol Chem. 1998 Dec 18;273(51):34543-50.PMID: 9852124 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Signalling pathways of insulin-like growth factor-I that are augmented by cAMP in FRTL-5 cells.

    Ariga M, Nedachi T, Akahori M, Sakamoto H, Ito Y, Hakuno F, Takahashi S.

    Biochem J. 2000 Jun 1;348 Pt 2:409-16.PMID: 10816436 [PubMed - indexed for MEDLINE]Related articlesFree article

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