PubMed

Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation.

Anthony JC, Reiter AK, Anthony TG, Crozier SJ, Lang CH, MacLean DA, Kimball SR, Jefferson LS.

Diabetes. 2002 Apr;51(4):928-36.PMID: 11916909 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral administration of leucine stimulates phosphorylation of 4E-bP1 and S6K 1 in skeletal muscle but not in liver of diabetic rats.

Yoshizawa F, Hirayama S, Sekizawa H, Nagasawa T, Sugahara K.

J Nutr Sci Vitaminol (Tokyo). 2002 Feb;48(1):59-64.PMID: 12026190 [PubMed - indexed for MEDLINE]Related articles

Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine.

Anthony JC, Lang CH, Crozier SJ, Anthony TG, MacLean DA, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2002 May;282(5):E1092-101.PMID: 11934675 [PubMed - indexed for MEDLINE]Related articlesFree article

Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle.

Lang CH, Frost RA.

J Cell Physiol. 2005 Apr;203(1):144-55.PMID: 15389631 [PubMed - indexed for MEDLINE]Related articles

Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle.

Lang CH, Frost RA, Deshpande N, Kumar V, Vary TC, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1205-15. Epub 2003 Aug 26.PMID: 12944322 [PubMed - indexed for MEDLINE]Related articlesFree article

Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway.

Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR.

J Nutr. 2000 Oct;130(10):2413-9.PMID: 11015466 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle.

Lang CH.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E666-74. Epub 2006 May 9.PMID: 16684854 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation.

Lang CH, Frost RA.

Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E721-30. Epub 2004 Jun 8.PMID: 15186995 [PubMed - indexed for MEDLINE]Related articlesFree article

Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation.

Anthony JC, Anthony TG, Kimball SR, Vary TC, Jefferson LS.

J Nutr. 2000 Feb;130(2):139-45.PMID: 10720160 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin fails to stimulate muscle protein synthesis in sepsis despite unimpaired signaling to 4E-BP1 and S6K1.

Vary TC, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E1045-53.PMID: 11595662 [PubMed - indexed for MEDLINE]Related articlesFree article

Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats.

Yoshizawa F, Sekizawa H, Hirayama S, Hatakeyama A, Nagasawa T, Sugahara K.

J Nutr Sci Vitaminol (Tokyo). 2001 Aug;47(4):311-5.PMID: 11767213 [PubMed - indexed for MEDLINE]Related articles

Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats.

Anthony TG, Anthony JC, Yoshizawa F, Kimball SR, Jefferson LS.

J Nutr. 2001 Apr;131(4):1171-6.PMID: 11285321 [PubMed - indexed for MEDLINE]Related articlesFree article

Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle.

Kumar V, Frost RA, Lang CH.

Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E917-28.PMID: 12376318 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate.

Yoshizawa F, Sekizawa H, Hirayama S, Yamazaki Y, Nagasawa T, Sugahara K.

J Nutr Sci Vitaminol (Tokyo). 2004 Feb;50(1):56-60.PMID: 15228219 [PubMed - indexed for MEDLINE]Related articles

Meal feeding enhances formation of eIF4F in skeletal muscle: role of increased eIF4E availability and eIF4G phosphorylation.

Vary TC, Lynch CJ.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E631-42. Epub 2005 Nov 1.PMID: 16263769 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats.

Vary TC.

J Nutr. 2007 Sep;137(9):2074-9.PMID: 17709445 [PubMed - indexed for MEDLINE]Related articlesFree article

IGF-I stimulates protein synthesis in skeletal muscle through multiple signaling pathways during sepsis.

Vary TC.

Am J Physiol Regul Integr Comp Physiol. 2006 Feb;290(2):R313-21. Epub 2005 Sep 8.PMID: 16150839 [PubMed - indexed for MEDLINE]Related articles

Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue.

Lynch CJ, Patson BJ, Anthony J, Vaval A, Jefferson LS, Vary TC.

Am J Physiol Endocrinol Metab. 2002 Sep;283(3):E503-13.PMID: 12169444 [PubMed - indexed for MEDLINE]Related articlesFree article

Leucine acutely reverses burn-induced alterations in translation initiation in heart.

Lang CH, Deshpande N, Frost RA.

Shock. 2004 Oct;22(4):326-32.PMID: 15377887 [PubMed - indexed for MEDLINE]Related articles

Oral leucine administration stimulates protein synthesis in rat skeletal muscle.

Crozier SJ, Kimball SR, Emmert SW, Anthony JC, Jefferson LS.

J Nutr. 2005 Mar;135(3):376-82.PMID: 15735066 [PubMed - indexed for MEDLINE]Related articlesFree article