PubMed

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

't Hart LM, Nijpels G, Dekker JM, Maassen JA, Heine RJ, van Haeften TW.

Diabetes. 2002 Mar;51(3):884-7.PMID: 11872698 [PubMed - indexed for MEDLINE]Related articlesFree article

Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.

't Hart LM, van Haeften TW, Dekker JM, Bot M, Heine RJ, Maassen JA.

Diabetes. 2002 Oct;51(10):3135-8.PMID: 12351459 [PubMed - indexed for MEDLINE]Related articlesFree article

Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.

Almind K, Frederiksen SK, Bernal D, Hansen T, Ambye L, Urhammer S, Ekstrøm CT, Berglund L, Reneland R, Lithell H, White MF, Van Obberghen E, Pedersen O.

Diabetologia. 1999 Oct;42(10):1244-9.PMID: 10525667 [PubMed - indexed for MEDLINE]Related articles

Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.

Ehrmann DA, Tang X, Yoshiuchi I, Cox NJ, Bell GI.

J Clin Endocrinol Metab. 2002 Sep;87(9):4297-300.PMID: 12213887 [PubMed - indexed for MEDLINE]Related articlesFree article

New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes.

Wang H, Rissanen J, Miettinen R, Kärkkäinen P, Kekäläinen P, Kuusisto J, Mykkänen L, Karhapää P, Laakso M.

Diabetes. 2001 Aug;50(8):1949-51.PMID: 11473060 [PubMed - indexed for MEDLINE]Related articlesFree article

The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells.

Porzio O, Federici M, Hribal ML, Lauro D, Accili D, Lauro R, Borboni P, Sesti G.

J Clin Invest. 1999 Aug;104(3):357-64.PMID: 10430617 [PubMed - indexed for MEDLINE]Related articlesFree article

Common amino acid substitutions in insulin receptor substrate-4 are not associated with Type II diabetes mellitus or insulin resistance.

Almind K, Frederiksen SK, Ahlgren MG, Urhammer S, Hansen T, Clausen JO, Pedersen O.

Diabetologia. 1998 Aug;41(8):969-74.PMID: 9726601 [PubMed - indexed for MEDLINE]Related articles

Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity.

Stefan N, Kovacs P, Stumvoll M, Hanson RL, Lehn-Stefan A, Permana PA, Baier LJ, Tataranni PA, Silver K, Bogardus C.

Diabetes. 2003 Jun;52(6):1544-50.PMID: 12765968 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Mexican Americans with Type 2 diabetes mellitus.

Celi FS, Negri C, Tanner K, Raben N, De Pablo F, Rovira A, Pallardo LF, Martin-Vaquero P, Stern MP, Mitchell BD, Shuldiner AR.

Diabetes Metab Res Rev. 2000 Sep-Oct;16(5):370-7.PMID: 11025561 [PubMed - indexed for MEDLINE]Related articles

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.

Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, Heine RJ, Maassen JA, Machicao F, Schäfer SA, Häring HU, 't Hart LM, van Haeften TW.

Diabetologia. 2008 Sep;51(9):1659-63. Epub 2008 Jul 11.PMID: 18618095 [PubMed - indexed for MEDLINE]Related articles

Genetic factors and insulin secretion: gene variants in the IGF genes.

't Hart LM, Fritsche A, Rietveld I, Dekker JM, Nijpels G, Machicao F, Stumvoll M, van Duijn CM, Häring HU, Heine RJ, Maassen JA, van Haeften TW.

Diabetes. 2004 Feb;53 Suppl 1:S26-30.PMID: 14749262 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes.

Koch M, Rett K, Volk A, Maerker E, Haist K, Deninger M, Renn W, Häring HU.

Exp Clin Endocrinol Diabetes. 1999;107(5):318-22.PMID: 10482045 [PubMed - indexed for MEDLINE]Related articles

Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus.

Hart LM, Dekker JM, van Haeften TW, Ruige JB, Stehouwer CD, Erkelens DW, Heine RJ, Maassen JA.

Diabetologia. 2000 Apr;43(4):515-9.PMID: 10819247 [PubMed - indexed for MEDLINE]Related articles

Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism.

Marchetti P, Lupi R, Federici M, Marselli L, Masini M, Boggi U, Del Guerra S, Patanè G, Piro S, Anello M, Bergamini E, Purrello F, Lauro R, Mosca F, Sesti G, Del Prato S.

Diabetes. 2002 May;51(5):1419-24.PMID: 11978638 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes.

D'Alfonso R, Marini MA, Frittitta L, Sorge R, Frontoni S, Porzio O, Mariani LM, Lauro D, Gambardella S, Trischitta V, Federici M, Lauro R, Sesti G.

J Clin Endocrinol Metab. 2003 Jan;88(1):317-22.PMID: 12519871 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction effect between common polymorphisms in PPARgamma2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity.

Stumvoll M, Stefan N, Fritsche A, Madaus A, Tschritter O, Koch M, Machicao F, Häring H.

J Mol Med. 2002 Jan;80(1):33-8. Epub 2001 Sep 15.PMID: 11862322 [PubMed - indexed for MEDLINE]Related articles

The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.

Marini MA, Frontoni S, Mineo D, Bracaglia D, Cardellini M, De Nicolais P, Baroni A, D'Alfonso R, Perna M, Lauro D, Federici M, Gambardella S, Lauro R, Sesti G.

J Clin Endocrinol Metab. 2003 Jul;88(7):3368-71.PMID: 12843189 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.

Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Deeb SS.

J Clin Invest. 1994 Sep;94(3):1141-6.PMID: 8083355 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular scanning of the insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms.

Ura S, Araki E, Kishikawa H, Shirotani T, Todaka M, Isami S, Shimoda S, Yoshimura R, Matsuda K, Motoyoshi S, Miyamura N, Kahn CR, Shichiri M.

Diabetologia. 1996 May;39(5):600-8.PMID: 8739921 [PubMed - indexed for MEDLINE]Related articles

Prevalence of variants in candidate genes for type 2 diabetes mellitus in The Netherlands: the Rotterdam study and the Hoorn study.

Hart LM, Stolk RP, Dekker JM, Nijpels G, Grobbee DE, Heine RJ, Maassen JA.

J Clin Endocrinol Metab. 1999 Mar;84(3):1002-6.PMID: 10084586 [PubMed - indexed for MEDLINE]Related articlesFree article