PubMed

Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes.

Mur C, Valverde AM, Kahn CR, Benito M.

Diabetes. 2002 Mar;51(3):743-54.PMID: 11872675 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation.

Mur C, Arribas M, Benito M, Valverde AM.

Endocrinology. 2003 Feb;144(2):581-93.PMID: 12538620 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.

Valverde AM, Mur C, Pons S, Alvarez AM, White MF, Kahn CR, Benito M.

Mol Cell Biol. 2001 Apr;21(7):2269-80.PMID: 11259577 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression.

Soon L, Flechner L, Gutkind JS, Wang LH, Baserga R, Pierce JH, Li W.

Mol Cell Biol. 1999 May;19(5):3816-28.PMID: 10207105 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor substrate (IRS) proteins IRS-1 and IRS-2 differential signaling in the insulin/insulin-like growth factor-I pathways in fetal brown adipocytes.

Valverde AM, Lorenzo M, Pons S, White MF, Benito M.

Mol Endocrinol. 1998 May;12(5):688-97.PMID: 9605931 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts.

Conejo R, Lorenzo M.

J Cell Physiol. 2001 Apr;187(1):96-108.PMID: 11241354 [PubMed - indexed for MEDLINE]Related articles

Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.

Arribas M, Valverde AM, Benito M.

J Biol Chem. 2003 Nov 14;278(46):45189-99. Epub 2003 Aug 27.PMID: 12944402 [PubMed - indexed for MEDLINE]Related articlesFree article

Tamoxifen interferes with the insulin-like growth factor I receptor (IGF-IR) signaling pathway in breast cancer cells.

Guvakova MA, Surmacz E.

Cancer Res. 1997 Jul 1;57(13):2606-10.PMID: 9205064 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

Valverde AM, Kahn CR, Benito M.

Diabetes. 1999 Nov;48(11):2122-31.PMID: 10535444 [PubMed - indexed for MEDLINE]Related articlesFree article

Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis.

Sasaoka T, Ishiki M, Wada T, Hori H, Hirai H, Haruta T, Ishihara H, Kobayashi M.

Endocrinology. 2001 Dec;142(12):5226-35.PMID: 11713219 [PubMed - indexed for MEDLINE]Related articlesFree article

p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes.

Porras A, Alvarez AM, Valladares A, Benito M.

Mol Endocrinol. 1998 Jun;12(6):825-34.PMID: 9626658 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway.

Kurihara S, Hakuno F, Takahashi S.

Endocr J. 2000 Dec;47(6):739-51.PMID: 11228049 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells.

Kim B, Leventhal PS, White MF, Feldman EL.

Endocrinology. 1998 Dec;139(12):4881-9.PMID: 9832424 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.

Cousin SP, Hügl SR, Myers MG Jr, White MF, Reifel-Miller A, Rhodes CJ.

Biochem J. 1999 Dec 15;344 Pt 3:649-58.PMID: 10585851 [PubMed - indexed for MEDLINE]Related articlesFree article

Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules.

Tanaka S, Ito T, Wands JR.

J Biol Chem. 1996 Jun 14;271(24):14610-6.PMID: 8662827 [PubMed - indexed for MEDLINE]Related articlesFree article

Different pathways of postreceptor desensitization following chronic insulin treatment and in cells overexpressing constitutively active insulin receptors.

Inoue G, Cheatham B, Kahn CR.

J Biol Chem. 1996 Nov 8;271(45):28206-11.PMID: 8910437 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of cyclic adenosine monophosphate on the mitogen-activated protein kinase pathway depends on both the cell type and the type of tyrosine kinase-receptor.

Calleja V, Ruiz Enríquez P, Filloux C, Peraldi P, Baron V, Van Obberghen E.

Endocrinology. 1997 Mar;138(3):1111-20.PMID: 9048617 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-induced egr-1 and c-fos expression in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and phosphatidylinositol 3-kinase activation.

Harada S, Smith RM, Smith JA, White MF, Jarett L.

J Biol Chem. 1996 Nov 22;271(47):30222-6. Erratum in: J Biol Chem 1997 Jan 31;272(5):3124. PMID: 8939974 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes.

Fasshauer M, Klein J, Kriauciunas KM, Ueki K, Benito M, Kahn CR.

Mol Cell Biol. 2001 Jan;21(1):319-29.PMID: 11113206 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation.

Venable CL, Frevert EU, Kim YB, Fischer BM, Kamatkar S, Neel BG, Kahn BB.

J Biol Chem. 2000 Jun 16;275(24):18318-26.PMID: 10751417 [PubMed - indexed for MEDLINE]Related articlesFree article