PubMed

Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydrogenase.

Tanizawa Y, Nakai K, Sasaki T, Anno T, Ohta Y, Inoue H, Matsuo K, Koga M, Furukawa S, Oka Y.

Diabetes. 2002 Mar;51(3):712-7.PMID: 11872671 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidation.

Anno T, Uehara S, Katagiri H, Ohta Y, Ueda K, Mizuguchi H, Moriyama Y, Oka Y, Tanizawa Y.

Am J Physiol Endocrinol Metab. 2004 Feb;286(2):E280-5. Epub 2003 Oct 7.PMID: 14532172 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice.

Li C, Matter A, Kelly A, Petty TJ, Najafi H, MacMullen C, Daikhin Y, Nissim I, Lazarow A, Kwagh J, Collins HW, Hsu BY, Nissim I, Yudkoff M, Matschinsky FM, Stanley CA.

J Biol Chem. 2006 Jun 2;281(22):15064-72. Epub 2006 Mar 30.PMID: 16574664 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutaminolysis and insulin secretion: from bedside to bench and back.

Kelly A, Li C, Gao Z, Stanley CA, Matschinsky FM.

Diabetes. 2002 Dec;51 Suppl 3:S421-6.PMID: 12475785 [PubMed - indexed for MEDLINE]Related articlesFree article

Unregulated insulin secretion by pancreatic beta cells in hyperinsulinism/hyperammonemia syndrome: role of glutamate dehydrogenase, ATP-sensitive potassium channel, and nonselective cation channel.

Kawajiri M, Okano Y, Kuno M, Tokuhara D, Hase Y, Inada H, Tashiro F, Miyazaki J, Yamano T.

Pediatr Res. 2006 Mar;59(3):359-64.PMID: 16492972 [PubMed - indexed for MEDLINE]Related articles

Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children.

Stanley CA.

Am J Clin Nutr. 2009 Sep;90(3):862S-866S. Epub 2009 Jul 22. Review.PMID: 19625687 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets.

Carobbio S, Ishihara H, Fernandez-Pascual S, Bartley C, Martin-Del-Rio R, Maechler P.

Diabetologia. 2004 Feb;47(2):266-76. Epub 2003 Dec 20.PMID: 14689183 [PubMed - indexed for MEDLINE]Related articles

Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase.

Li C, Allen A, Kwagh J, Doliba NM, Qin W, Najafi H, Collins HW, Matschinsky FM, Stanley CA, Smith TJ.

J Biol Chem. 2006 Apr 14;281(15):10214-21. Epub 2006 Feb 13.PMID: 16476731 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators.

Stanley CA, Fang J, Kutyna K, Hsu BY, Ming JE, Glaser B, Poncz M.

Diabetes. 2000 Apr;49(4):667-73.PMID: 10871207 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene.

Stanley CA, Lieu YK, Hsu BY, Burlina AB, Greenberg CR, Hopwood NJ, Perlman K, Rich BH, Zammarchi E, Poncz M.

N Engl J Med. 1998 May 7;338(19):1352-7.PMID: 9571255 [PubMed - indexed for MEDLINE]Related articlesFree article

Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.

MacFarlane WM, Chapman JC, Shepherd RM, Hashmi MN, Kamimura N, Cosgrove KE, O'Brien RE, Barnes PD, Hart AW, Docherty HM, Lindley KJ, Aynsley-Green A, James RF, Docherty K, Dunne MJ.

J Biol Chem. 1999 Nov 26;274(48):34059-66.PMID: 10567373 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets.

Li C, Najafi H, Daikhin Y, Nissim IB, Collins HW, Yudkoff M, Matschinsky FM, Stanley CA.

J Biol Chem. 2003 Jan 31;278(5):2853-8. Epub 2002 Nov 19.PMID: 12444083 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase.

MacMullen C, Fang J, Hsu BY, Kelly A, de Lonlay-Debeney P, Saudubray JM, Ganguly A, Smith TJ, Stanley CA; Hyperinsulinism/hyperammonemia Contributing Investigators.

J Clin Endocrinol Metab. 2001 Apr;86(4):1782-7.PMID: 11297618 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics.

Yorifuji T, Muroi J, Uematsu A, Hiramatsu H, Momoi T.

Hum Genet. 1999 Jun;104(6):476-9.PMID: 10453735 [PubMed - indexed for MEDLINE]Related articles

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L.

Cell. 2006 Sep 8;126(5):941-54.PMID: 16959573 [PubMed - indexed for MEDLINE]Related articles

Hyperinsulinism and hyperammonemia syndrome: report of twelve unrelated patients.

De Lonlay P, Benelli C, Fouque F, Ganguly A, Aral B, Dionisi-Vici C, Touati G, Heinrichs C, Rabier D, Kamoun P, Robert JJ, Stanley C, Saudubray JM.

Pediatr Res. 2001 Sep;50(3):353-7.PMID: 11518822 [PubMed - indexed for MEDLINE]Related articles

Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.

Plaitakis A, Metaxari M, Shashidharan P.

J Neurochem. 2000 Nov;75(5):1862-9.PMID: 11032875 [PubMed - indexed for MEDLINE]Related articles

Glucose regulation of glutaminolysis and its role in insulin secretion.

Gao ZY, Li G, Najafi H, Wolf BA, Matschinsky FM.

Diabetes. 1999 Aug;48(8):1535-42.PMID: 10426370 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations.

Fang J, Hsu BY, MacMullen CM, Poncz M, Smith TJ, Stanley CA.

Biochem J. 2002 Apr 1;363(Pt 1):81-7.PMID: 11903050 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of genes encoding the pancreatic beta-cell ATP-sensitive K+ channel in persistent hyperinsulinemic hypoglycemia of infancy in Japanese patients.

Someya T, Miki T, Sugihara S, Minagawa M, Yasuda T, Kohno Y, Seino S.

Endocr J. 2000 Dec;47(6):715-22.PMID: 11228046 [PubMed - indexed for MEDLINE]Related articles