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    Results: 1 to 20 of 250

    1.

    Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats.

    Hinke SA, Gelling RW, Pederson RA, Manhart S, Nian C, Demuth HU, McIntosh CH.

    Diabetes. 2002 Mar;51(3):652-61.PMID: 11872663 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    [Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo.

    Hinke SA, Manhart S, Kühn-Wache K, Nian C, Demuth HU, Pederson RA, McIntosh CH.

    J Biol Chem. 2004 Feb 6;279(6):3998-4006. Epub 2003 Nov 10.PMID: 14610075 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.

    Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA.

    Diabetes. 2001 May;50(5):1004-11.PMID: 11334402 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes.

    Gault VA, Flatt PR, Bailey CJ, Harriott P, Greer B, Mooney MH, O'harte FP.

    Biochem J. 2002 Nov 1;367(Pt 3):913-20.PMID: 12150711 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP).

    Hinke SA, Manhart S, Pamir N, Demuth H, W Gelling R, Pederson RA, McIntosh CH.

    Biochim Biophys Acta. 2001 May 5;1547(1):143-55.PMID: 11343800 [PubMed - indexed for MEDLINE]Related articles

    6.

    GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.

    Deacon CF, Plamboeck A, Rosenkilde MM, de Heer J, Holst JJ.

    Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E468-75. Epub 2006 Apr 11.PMID: 16608883 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo.

    Gault VA, O'Harte FP, Harriott P, Flatt PR.

    Metabolism. 2003 Jun;52(6):679-87.PMID: 12800091 [PubMed - indexed for MEDLINE]Related articles

    8.

    A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide.

    Green BD, Gault VA, O'Harte FP, Flatt PR.

    Diabetes Obes Metab. 2005 Sep;7(5):595-604.PMID: 16050953 [PubMed - indexed for MEDLINE]Related articles

    9.

    Antagonistic effects of two novel GIP analogs, (Hyp3)GIP and (Hyp3)GIPLys16PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice.

    O'Harte FP, Hunter K, Gault VA, Irwin N, Green BD, Greer B, Harriott P, Bailey CJ, Flatt PR.

    Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1674-82. Epub 2007 Feb 13.PMID: 17299087 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential.

    Irwin N, O'Harte FP, Gault VA, Green BD, Greer B, Harriott P, Bailey CJ, Flatt PR.

    J Med Chem. 2006 Feb 9;49(3):1047-54.PMID: 16451070 [PubMed - indexed for MEDLINE]Related articles

    11.

    Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

    Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA.

    Diabetes. 2003 Mar;52(3):741-50.PMID: 12606516 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice.

    Irwin N, McClean PL, Flatt PR.

    J Pept Sci. 2007 Jun;13(6):400-5.PMID: 17486662 [PubMed - indexed for MEDLINE]Related articles

    13.

    Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study.

    Pospisilik JA, Stafford SG, Demuth HU, McIntosh CH, Pederson RA.

    Diabetes. 2002 Sep;51(9):2677-83.PMID: 12196458 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats.

    Sudre B, Broqua P, White RB, Ashworth D, Evans DM, Haigh R, Junien JL, Aubert ML.

    Diabetes. 2002 May;51(5):1461-9.PMID: 11978643 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP.

    O'Harte FP, Gault VA, Parker JC, Harriott P, Mooney MH, Bailey CJ, Flatt PR.

    Diabetologia. 2002 Sep;45(9):1281-91. Epub 2002 Jul 16.PMID: 12242461 [PubMed - indexed for MEDLINE]Related articles

    16.

    Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.

    Green BD, Gault VA, Flatt PR, Harriott P, Greer B, O'Harte FP.

    Arch Biochem Biophys. 2004 Aug 15;428(2):136-43.PMID: 15246869 [PubMed - indexed for MEDLINE]Related articles

    17.

    Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats.

    Pospisilik JA, Stafford SG, Demuth HU, Brownsey R, Parkhouse W, Finegood DT, McIntosh CH, Pederson RA.

    Diabetes. 2002 Apr;51(4):943-50.PMID: 11916911 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    The enteroinsular axis in dipeptidyl peptidase IV-negative rats.

    Pederson RA, Kieffer TJ, Pauly R, Kofod H, Kwong J, McIntosh CH.

    Metabolism. 1996 Nov;45(11):1335-41.PMID: 8931636 [PubMed - indexed for MEDLINE]Related articles

    19.

    Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats.

    Balkan B, Kwasnik L, Miserendino R, Holst JJ, Li X.

    Diabetologia. 1999 Nov;42(11):1324-31.PMID: 10550416 [PubMed - indexed for MEDLINE]Related articles

    20.

    Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide.

    Gault VA, O'Harte FP, Harriott P, Flatt PR.

    Biochem Biophys Res Commun. 2002 Feb 8;290(5):1420-6.PMID: 11820780 [PubMed - indexed for MEDLINE]Related articles

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