PubMed

Lipotoxicity in human pancreatic islets and the protective effect of metformin.

Lupi R, Del Guerra S, Fierabracci V, Marselli L, Novelli M, Patanè G, Boggi U, Mosca F, Piro S, Del Prato S, Marchetti P.

Diabetes. 2002 Feb;51 Suppl 1:S134-7.PMID: 11815472 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

Patanè G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F.

Diabetes. 2000 May;49(5):735-40.PMID: 10905481 [PubMed - indexed for MEDLINE]Related articlesFree article

The biguanide compound metformin prevents desensitization of human pancreatic islets induced by high glucose.

Lupi R, Del Guerra S, Tellini C, Giannarelli R, Coppelli A, Lorenzetti M, Carmellini M, Mosca F, Navalesi R, Marchetti P.

Eur J Pharmacol. 1999 Jan 8;364(2-3):205-9.PMID: 9932725 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S.

Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E560-7. Epub 2003 Nov 18.PMID: 14625208 [PubMed - indexed for MEDLINE]Related articlesFree article

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.

Zhou YP, Grill V.

J Clin Endocrinol Metab. 1995 May;80(5):1584-90.PMID: 7745004 [PubMed - indexed for MEDLINE]Related articles

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P.

Diabetes. 2002 May;51(5):1437-42.PMID: 11978640 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-esterified fatty acids are deleterious for human pancreatic islet function at physiological glucose concentration.

Dubois M, Kerr-Conte J, Gmyr V, Bouckenooghe T, Muharram G, D'Herbomez M, Martin-Ponthieu A, Vantyghem MC, Vandewalle B, Pattou F.

Diabetologia. 2004 Mar;47(3):463-9. Epub 2004 Feb 13.PMID: 14968298 [PubMed - indexed for MEDLINE]Related articles

Acute and chronic effects of different concentrations of free fatty acids on the insulin secreting function of islets.

Ayvaz G, Balos Törüner F, Karakoç A, Yetkin I, Cakir N, Arslan M.

Diabetes Metab. 2002 Dec;28(6 Pt 2):3S7-12; discussion 3S108-12.PMID: 12688627 [PubMed - indexed for MEDLINE]Related articles

Glyburide and tolbutamide induce desensitization of insulin release in rat pancreatic islets by different mechanisms.

Rabuazzo AM, Buscema M, Vinci C, Caltabiano V, Vetri M, Forte F, Vigneri R, Purrello F.

Endocrinology. 1992 Oct;131(4):1815-20.PMID: 1396327 [PubMed - indexed for MEDLINE]Related articles

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

Zhou YP, Grill VE.

J Clin Invest. 1994 Feb;93(2):870-6.PMID: 8113418 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition.

Patanè G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM.

Diabetes. 2002 Sep;51(9):2749-56.PMID: 12196468 [PubMed - indexed for MEDLINE]Related articlesFree article

Augmentation of Ca2+-stimulated insulin release by glucose and long-chain fatty acids in rat pancreatic islets: free fatty acids mimic ATP-sensitive K+ channel-independent insulinotropic action of glucose.

Komatsu M, Yajima H, Yamada S, Kaneko T, Sato Y, Yamauchi K, Hashizume K, Aizawa T.

Diabetes. 1999 Aug;48(8):1543-9.PMID: 10426371 [PubMed - indexed for MEDLINE]Related articlesFree article

Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets.

Tian JY, Li G, Gu YY, Zhang HL, Zhou WZ, Wang X, Zhu HD, Luo TH, Luo M.

Chin Med J (Engl). 2006 Apr 5;119(7):574-80.PMID: 16620699 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release.

Elks ML.

Endocrinology. 1993 Jul;133(1):208-14.PMID: 8319569 [PubMed - indexed for MEDLINE]Related articles

Effects of glibenclamide and metformin (alone or in combination) on insulin release from isolated human pancreatic islets.

Lupi R, Marchetti P, Giannarelli R, Coppelli A, Tellini C, Del Guerra S, Lorenzetti M, Carmellini M, Mosca F, Navalesi R.

Acta Diabetol. 1997 Mar;34(1):46-8.PMID: 9134058 [PubMed - indexed for MEDLINE]Related articles

Fast reversibility of glucose-induced desensitization in rat pancreatic islets. Evidence for an involvement of ionic fluxes.

Anello M, Rabuazzo AM, Degano C, Caltabiano V, Patanè G, Vigneri R, Purrello F.

Diabetes. 1996 Apr;45(4):502-6.PMID: 8603773 [PubMed - indexed for MEDLINE]Related articles

The non-peptidyl low molecular weight radical scavenger IAC protects human pancreatic islets from lipotoxicity.

D'Aleo V, Del Guerra S, Martano M, Bonamassa B, Canistro D, Soleti A, Valgimigli L, Paolini M, Filipponi F, Boggi U, Del Prato S, Lupi R.

Mol Cell Endocrinol. 2009 Oct 15;309(1-2):63-6. Epub 2009 May 27.PMID: 19481137 [PubMed - indexed for MEDLINE]Related articles

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death.

El-Assaad W, Buteau J, Peyot ML, Nolan C, Roduit R, Hardy S, Joly E, Dbaibo G, Rosenberg L, Prentki M.

Endocrinology. 2003 Sep;144(9):4154-63.PMID: 12933690 [PubMed - indexed for MEDLINE]Related articlesFree article

A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.

Zhou YP, Berggren PO, Grill V.

Diabetes. 1996 May;45(5):580-6.PMID: 8621007 [PubMed - indexed for MEDLINE]Related articles

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.

Olofsson CS, Collins S, Bengtsson M, Eliasson L, Salehi A, Shimomura K, Tarasov A, Holm C, Ashcroft F, Rorsman P.

Diabetes. 2007 Jul;56(7):1888-97. Epub 2007 Apr 24.PMID: 17456851 [PubMed - indexed for MEDLINE]Related articlesFree article