PubMed

Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?

Gerich JE.

Diabetes. 2002 Feb;51 Suppl 1:S117-21. Review.PMID: 11815469 [PubMed - indexed for MEDLINE]Related articlesFree article

Phasic insulin release and metabolic regulation in type 2 diabetes.

Del Prato S, Marchetti P, Bonadonna RC.

Diabetes. 2002 Feb;51 Suppl 1:S109-16. Review.PMID: 11815468 [PubMed - indexed for MEDLINE]Related articlesFree article

Modeling phasic insulin release: immediate and time-dependent effects of glucose.

Nesher R, Cerasi E.

Diabetes. 2002 Feb;51 Suppl 1:S53-9. Review.PMID: 11815459 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential role of oral thiazolidinedione therapy in preserving beta-cell function in type 2 diabetes mellitus.

Walter H, Lübben G.

Drugs. 2005;65(1):1-13. Review.PMID: 15610048 [PubMed - indexed for MEDLINE]Related articles

One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.

Degn KB, Juhl CB, Sturis J, Jakobsen G, Brock B, Chandramouli V, Rungby J, Landau BR, Schmitz O.

Diabetes. 2004 May;53(5):1187-94.PMID: 15111485 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes.

Knowles NG, Landchild MA, Fujimoto WY, Kahn SE.

Diabetes Care. 2002 Feb;25(2):292-7.PMID: 11815498 [PubMed - indexed for MEDLINE]Related articlesFree article

[Pathogenesis of type 2 diabetes mellitus]

Guillausseau PJ, Laloi-Michelin M.

Rev Med Interne. 2003 Nov;24(11):730-7. Review. French. PMID: 14604750 [PubMed - indexed for MEDLINE]Related articles

Alteration of beta-cell constitutive NO synthase activity is involved in the abnormal insulin response to arginine in a new rat model of type 2 diabetes.

Novelli M, Pocai A, Lajoix AD, Beffy P, Bezzi D, Marchetti P, Gross R, Masiello P.

Mol Cell Endocrinol. 2004 Apr 30;219(1-2):77-82.PMID: 15149729 [PubMed - indexed for MEDLINE]Related articles

Early disturbances in insulin secretion in the development of type 2 diabetes mellitus.

van Haeften TW.

Mol Cell Endocrinol. 2002 Nov 29;197(1-2):197-204. Review.PMID: 12431813 [PubMed - indexed for MEDLINE]Related articles

Pathogenesis of type 2 diabetes mellitus.

Leahy JL.

Arch Med Res. 2005 May-Jun;36(3):197-209. Review.PMID: 15925010 [PubMed - indexed for MEDLINE]Related articles

[Application of hyperglycemic clamp technique in the assessment of beta-cell function in obese individuals with glucose intolerance]

Bao YQ, Jia WP, Zhu M, Lu JX, Chen L, Xiang KS.

Zhonghua Yi Xue Za Zhi. 2004 Nov 2;84(21):1781-4. Chinese. PMID: 15631773 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance, diabetes, and the adipocyte.

Stolar MW.

Am J Health Syst Pharm. 2002 Dec 1;59 Suppl 9:S3-8. Review.PMID: 12489380 [PubMed - indexed for MEDLINE]Related articles

[And what about diabetes?]

Cerasi E.

Bull Acad Natl Med. 2007 Apr-May;191(4-5):941-3; discussion 943. French. PMID: 18225448 [PubMed - indexed for MEDLINE]Related articles

Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans.

Quddusi S, Vahl TP, Hanson K, Prigeon RL, D'Alessio DA.

Diabetes Care. 2003 Mar;26(3):791-8.PMID: 12610039 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology?

Patti ME.

Curr Opin Clin Nutr Metab Care. 2004 Jul;7(4):383-90. Review.PMID: 15192439 [PubMed - indexed for MEDLINE]Related articles

Bezafibrate on lipids and glucose metabolism in obese diabetic Otsuka Long-Evans Tokushima fatty rats.

Jia D, Yamamoto M, Otani M, Otsuki M.

Metabolism. 2004 Apr;53(4):405-13.PMID: 15045684 [PubMed - indexed for MEDLINE]Related articles

Advances in diabetes for the millennium: understanding insulin resistance.

Gerich JE, Dailey G.

MedGenMed. 2004 Aug 26;6(3 Suppl):11. Review.PMID: 15647716 [PubMed - indexed for MEDLINE]Related articlesFree article

The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype.

Vilsbøll T, Knop FK, Krarup T, Johansen A, Madsbad S, Larsen S, Hansen T, Pedersen O, Holst JJ.

J Clin Endocrinol Metab. 2003 Oct;88(10):4897-903.PMID: 14557471 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired beta-cell and alpha-cell function in African-American children with type 2 diabetes mellitus--"Flatbush diabetes".

Banerji MA.

J Pediatr Endocrinol Metab. 2002 Apr;15 Suppl 1:493-501. Review.PMID: 12017222 [PubMed - indexed for MEDLINE]Related articles

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

Butler AE, Janson J, Soeller WC, Butler PC.

Diabetes. 2003 Sep;52(9):2304-14.PMID: 12941770 [PubMed - indexed for MEDLINE]Related articlesFree article