PubMed

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.

Barg S, Eliasson L, Renström E, Rorsman P.

Diabetes. 2002 Feb;51 Suppl 1:S74-82. Review.PMID: 11815462 [PubMed - indexed for MEDLINE]Related articlesFree article

Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion.

Bratanova-Tochkova TK, Cheng H, Daniel S, Gunawardana S, Liu YJ, Mulvaney-Musa J, Schermerhorn T, Straub SG, Yajima H, Sharp GW.

Diabetes. 2002 Feb;51 Suppl 1:S83-90. Review.PMID: 11815463 [PubMed - indexed for MEDLINE]Related articlesFree article

Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.

Göpel S, Zhang Q, Eliasson L, Ma XS, Galvanovskis J, Kanno T, Salehi A, Rorsman P.

J Physiol. 2004 May 1;556(Pt 3):711-26. Epub 2004 Feb 13.PMID: 14966302 [PubMed - indexed for MEDLINE]Related articlesFree article

Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification.

Barg S, Huang P, Eliasson L, Nelson DJ, Obermüller S, Rorsman P, Thévenod F, Renström E.

J Cell Sci. 2001 Jun;114(Pt 11):2145-54.PMID: 11493650 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-stimulated signaling pathways in biphasic insulin secretion.

Straub SG, Sharp GW.

Diabetes Metab Res Rev. 2002 Nov-Dec;18(6):451-63. Review.PMID: 12469359 [PubMed - indexed for MEDLINE]Related articles

CaV2.3 calcium channels control second-phase insulin release.

Jing X, Li DQ, Olofsson CS, Salehi A, Surve VV, Caballero J, Ivarsson R, Lundquist I, Pereverzev A, Schneider T, Rorsman P, Renström E.

J Clin Invest. 2005 Jan;115(1):146-54.PMID: 15630454 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels.

Mears D.

J Membr Biol. 2004 Jul 15;200(2):57-66. Review.PMID: 15520904 [PubMed - indexed for MEDLINE]Related articles

Glucose acutely decreases pH of secretory granules in mouse pancreatic islets. Mechanisms and influence on insulin secretion.

Stiernet P, Guiot Y, Gilon P, Henquin JC.

J Biol Chem. 2006 Aug 4;281(31):22142-51. Epub 2006 Jun 7.PMID: 16760469 [PubMed - indexed for MEDLINE]Related articlesFree article

Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.

Braun M, Ramracheya R, Bengtsson M, Zhang Q, Karanauskaite J, Partridge C, Johnson PR, Rorsman P.

Diabetes. 2008 Jun;57(6):1618-28. Epub 2008 Apr 4.PMID: 18390794 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells.

Olofsson CS, Salehi A, Holm C, Rorsman P.

J Physiol. 2004 Jun 15;557(Pt 3):935-48. Epub 2004 Apr 16.PMID: 15090611 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.

Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, Wollheim CB, Rorsman P, Hofmann F.

EMBO J. 2003 Aug 1;22(15):3844-54.PMID: 12881419 [PubMed - indexed for MEDLINE]Related articlesFree article

Newcomer insulin secretory granules as a highly calcium-sensitive pool.

Pedersen MG, Sherman A.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7432-6. Epub 2009 Apr 16.PMID: 19372374 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyposmotic shock stimulates insulin secretion by two distinct mechanisms. Studies with the betaHC9 cell.

Straub SG, Daniel S, Sharp GW.

Am J Physiol Endocrinol Metab. 2002 May;282(5):E1070-6.PMID: 11934672 [PubMed - indexed for MEDLINE]Related articlesFree article

Electrical activity and exocytotic correlates of biphasic insulin secretion from beta-cells of canine islets of Langerhans: contribution of tuning two modes of Ca2+ entry-dependent exocytosis to two modes of glucose-induced electrical activity.

Misler S, Zhou Z, Dickey AS, Silva AM, Pressel DM, Barnett DW.

Channels (Austin). 2009 May-Jun;3(3):181-93. Epub 2009 May 11.PMID: 19535907 [PubMed - indexed for MEDLINE]Related articlesFree article

Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.

Olofsson CS, Göpel SO, Barg S, Galvanovskis J, Ma X, Salehi A, Rorsman P, Eliasson L.

Pflugers Arch. 2002 May;444(1-2):43-51. Epub 2002 Jan 31.PMID: 11976915 [PubMed - indexed for MEDLINE]Related articles

Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels.

Geng X, Li L, Bottino R, Balamurugan AN, Bertera S, Densmore E, Su A, Chang Y, Trucco M, Drain P.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E293-301. Epub 2007 Apr 3.PMID: 17405830 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion.

Straub SG, Sharp GW.

Am J Physiol Cell Physiol. 2004 Sep;287(3):C565-71. Review.PMID: 15308461 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.

Xia F, Xie L, Mihic A, Gao X, Chen Y, Gaisano HY, Tsushima RG.

Endocrinology. 2008 Oct;149(10):5136-45. Epub 2008 Jul 3.PMID: 18599549 [PubMed - indexed for MEDLINE]Related articlesFree article

Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins.

Thévenod F.

Am J Physiol Cell Physiol. 2002 Sep;283(3):C651-72. Review.PMID: 12176723 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.

Szollosi A, Nenquin M, Aguilar-Bryan L, Bryan J, Henquin JC.

J Biol Chem. 2007 Jan 19;282(3):1747-56. Epub 2006 Nov 30.PMID: 17138557 [PubMed - indexed for MEDLINE]Related articlesFree article