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    Results: 1 to 20 of 139

    1.

    Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia.

    Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, Weir GC.

    Diabetes. 2002 Feb;51(2):413-23.PMID: 11812749 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.

    Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC.

    J Biol Chem. 2003 Jan 31;278(5):2997-3005. Epub 2002 Nov 15.PMID: 12438314 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.

    Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC.

    J Biol Chem. 2002 Mar 29;277(13):10912-21. Epub 2002 Jan 8.PMID: 11782487 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Inhibitory effects of epicatechin on interleukin-1beta-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation.

    Kim MJ, Ryu GR, Kang JH, Sim SS, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Jeong IK, Hong KJ, Kim MS, Jo YH.

    Biochem Pharmacol. 2004 Nov 1;68(9):1775-85.PMID: 15450943 [PubMed - indexed for MEDLINE]Related articles

    5.

    Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes.

    Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patanè G, Laybutt R, Bonner-Weir S, Weir GC.

    J Biol Chem. 1999 May 14;274(20):14112-21.PMID: 10318828 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy.

    Zangen DH, Bonner-Weir S, Lee CH, Latimer JB, Miller CP, Habener JF, Weir GC.

    Diabetes. 1997 Feb;46(2):258-64.PMID: 9000703 [PubMed - indexed for MEDLINE]Related articles

    7.

    Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus.

    Welsh N, Margulis B, Borg LA, Wiklund HJ, Saldeen J, Flodström M, Mello MA, Andersson A, Pipeleers DG, Hellerström C, et al.

    Mol Med. 1995 Nov;1(7):806-20.PMID: 8612203 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets.

    Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C.

    J Exp Med. 1999 Oct 18;190(8):1135-46.PMID: 10523611 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.

    Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M.

    Diabetes. 2003 Jan;52(1):93-101.PMID: 12502498 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation.

    Kim EK, Kwon KB, Song MY, Han MJ, Lee JH, Lee YR, Lee JH, Ryu DG, Park BH, Park JW.

    Pancreas. 2007 Nov;35(4):e1-9.PMID: 18090225 [PubMed - indexed for MEDLINE]Related articles

    11.

    beta-cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia.

    Liu YQ, Nevin PW, Leahy JL.

    Am J Physiol Endocrinol Metab. 2000 Jul;279(1):E68-73.PMID: 10893324 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    A role of nicotinamide-induced increase in pancreatic beta-cell mass on blood glucose control after discontinuation of the treatment in partially pancreatectomized OLETF rats.

    Shima K, Zhu M, Kuwajima M.

    Diabetes Res Clin Pract. 1998 Jul;41(1):1-8.PMID: 9768366 [PubMed - indexed for MEDLINE]Related articles

    13.

    Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes.

    Shukla S, Gupta S.

    Clin Cancer Res. 2004 May 1;10(9):3169-78.PMID: 15131058 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Exercise and dexamethasone oppositely modulate beta-cell function and survival via independent pathways in 90% pancreatectomized rats.

    Choi SB, Jang JS, Hong SM, Jun DW, Park S.

    J Endocrinol. 2006 Aug;190(2):471-82.PMID: 16899580 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

    Donath MY, Gross DJ, Cerasi E, Kaiser N.

    Diabetes. 1999 Apr;48(4):738-44.PMID: 10102689 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.

    Kjørholt C, Akerfeldt MC, Biden TJ, Laybutt DR.

    Diabetes. 2005 Sep;54(9):2755-63.PMID: 16123366 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    The non-peptidyl low molecular weight radical scavenger IAC protects human pancreatic islets from lipotoxicity.

    D'Aleo V, Del Guerra S, Martano M, Bonamassa B, Canistro D, Soleti A, Valgimigli L, Paolini M, Filipponi F, Boggi U, Del Prato S, Lupi R.

    Mol Cell Endocrinol. 2009 Oct 15;309(1-2):63-6. Epub 2009 May 27.PMID: 19481137 [PubMed - indexed for MEDLINE]Related articles

    18.

    Ovarian hormone-induced beta-cell hypertrophy contributes to the homeostatic control of beta-cell mass in OLETF female rat, a model of Type II diabetes.

    Zhu M, Mizuno A, Kuwajima M, Ogino T, Murakami T, Noma Y, Sano T, Shima K.

    Diabetologia. 1998 Jul;41(7):799-805.PMID: 9686921 [PubMed - indexed for MEDLINE]Related articles

    19.

    Islet graft response to transplantation injury includes upregulation of protective as well as apoptotic genes.

    Rodríguez-Mulero S, Montanya E.

    Cell Transplant. 2008;17(9):1025-34.PMID: 19177839 [PubMed - indexed for MEDLINE]Related articles

    20.

    Effect of partial pancreatectomy on beta-cell mass in the remnant pancreas of Wistar fatty rats.

    Ogino T, Zhu M, Murakami T, Kuwajima M, Shima K.

    J Med Invest. 1998 Aug;45(1-4):103-10.PMID: 9864970 [PubMed - indexed for MEDLINE]Related articles

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