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    Results: 1 to 20 of 178

    1.

    Glucagon replacement via micro-osmotic pump corrects hypoglycemia and alpha-cell hyperplasia in prohormone convertase 2 knockout mice.

    Webb GC, Akbar MS, Zhao C, Swift HH, Steiner DF.

    Diabetes. 2002 Feb;51(2):398-405.PMID: 11812747 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.

    Vincent M, Guz Y, Rozenberg M, Webb G, Furuta M, Steiner D, Teitelman G.

    Endocrinology. 2003 Sep;144(9):4061-9.PMID: 12933680 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.

    Furuta M, Zhou A, Webb G, Carroll R, Ravazzola M, Orci L, Steiner DF.

    J Biol Chem. 2001 Jul 20;276(29):27197-202. Epub 2001 May 16.PMID: 11356850 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

    Furuta M, Yano H, Zhou A, Rouillé Y, Holst JJ, Carroll R, Ravazzola M, Orci L, Furuta H, Steiner DF.

    Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6646-51.PMID: 9192619 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice.

    Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ.

    Diabetes. 2007 Nov;56(11):2744-52. Epub 2007 Aug 13.PMID: 17698597 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Proglucagon processing in an islet cell line: effects of PC1 overexpression and PC2 depletion.

    Dhanvantari S, Brubaker PL.

    Endocrinology. 1998 Apr;139(4):1630-7.PMID: 9528943 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.

    Rouillé Y, Westermark G, Martin SK, Steiner DF.

    Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3242-6.PMID: 8159732 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets.

    Webb GC, Dey A, Wang J, Stein J, Milewski M, Steiner DF.

    J Biol Chem. 2004 Jul 23;279(30):31068-75. Epub 2004 May 13.PMID: 15143067 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.

    Wang J, Xu J, Finnerty J, Furuta M, Steiner DF, Verchere CB.

    Diabetes. 2001 Mar;50(3):534-9.PMID: 11246872 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.

    Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB.

    Diabetes. 2006 Aug;55(8):2192-201.PMID: 16873681 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon.

    Rouillé Y, Bianchi M, Irminger JC, Halban PA.

    FEBS Lett. 1997 Aug 11;413(1):119-23.PMID: 9287128 [PubMed - indexed for MEDLINE]Related articles

    12.

    [Impact of islet alpha cell loss on insulin secretion]

    Li G, Ye L, Li J, Yang W, Lou J.

    Zhonghua Yi Xue Za Zhi. 2002 Oct 25;82(20):1427-31. Chinese. PMID: 12509929 [PubMed - indexed for MEDLINE]Related articles

    13.

    Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice.

    Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, Charron MJ.

    Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1438-43. Epub 2003 Jan 24.PMID: 12552113 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans.

    Martin SK, Carroll R, Benig M, Steiner DF.

    FEBS Lett. 1994 Dec 19;356(2-3):279-82.PMID: 7805854 [PubMed - indexed for MEDLINE]Related articles

    15.

    Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency.

    Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L, Nackers L, Pack S, Jou W, Weinstein LS.

    J Clin Invest. 2005 Nov;115(11):3217-27. Epub 2005 Oct 20.PMID: 16239968 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).

    Wideman RD, Yu IL, Webber TD, Verchere CB, Johnson JD, Cheung AT, Kieffer TJ.

    Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13468-73. Epub 2006 Aug 28.PMID: 16938896 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

    Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

    Endocrinology. 2002 Apr;143(4):1530-7.PMID: 11897712 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2.

    Damholt AB, Buchan AM, Holst JJ, Kofod H.

    Endocrinology. 1999 Oct;140(10):4800-8.PMID: 10499540 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.

    Zhu X, Orci L, Carroll R, Norrbom C, Ravazzola M, Steiner DF.

    Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10299-304. Epub 2002 Jul 22.PMID: 12136131 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Defective prodynorphin processing in mice lacking prohormone convertase PC2.

    Berman Y, Mzhavia N, Polonskaia A, Furuta M, Steiner DF, Pintar JE, Devi LA.

    J Neurochem. 2000 Oct;75(4):1763-70.PMID: 10987860 [PubMed - indexed for MEDLINE]Related articles

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