PubMed

Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production.

Thomas HE, Darwiche R, Corbett JA, Kay TW.

Diabetes. 2002 Feb;51(2):311-6.PMID: 11812737 [PubMed - indexed for MEDLINE]Related articlesFree article

Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1.

Heitmeier MR, Scarim AL, Corbett JA.

J Biol Chem. 1997 May 23;272(21):13697-704.PMID: 9153221 [PubMed - indexed for MEDLINE]Related articlesFree article

Double-stranded RNA inhibits beta-cell function and induces islet damage by stimulating beta-cell production of nitric oxide.

Heitmeier MR, Scarim AL, Corbett JA.

J Biol Chem. 1999 Apr 30;274(18):12531-6.PMID: 10212230 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1 produced and released endogenously within human islets inhibits beta cell function.

Arnush M, Heitmeier MR, Scarim AL, Marino MH, Manning PT, Corbett JA.

J Clin Invest. 1998 Aug 1;102(3):516-26.PMID: 9691088 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged STAT1 activation is associated with interferon-gamma priming for interleukin-1-induced inducible nitric-oxide synthase expression by islets of Langerhans.

Heitmeier MR, Scarim AL, Corbett JA.

J Biol Chem. 1999 Oct 8;274(41):29266-73.PMID: 10506184 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine-induced inhibition of insulin release from mouse pancreatic beta-cells deficient in inducible nitric oxide synthase.

Andersson AK, Flodström M, Sandler S.

Biochem Biophys Res Commun. 2001 Feb 23;281(2):396-403.PMID: 11181061 [PubMed - indexed for MEDLINE]Related articles

The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.

Pavlovic D, Chen MC, Gysemans CA, Mathieu C, Eizirik DL.

Eur Cytokine Netw. 1999 Sep;10(3):403-12.PMID: 10477397 [PubMed - indexed for MEDLINE]Related articles

Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells.

Darville MI, Eizirik DL.

Diabetologia. 1998 Sep;41(9):1101-8.PMID: 9754830 [PubMed - indexed for MEDLINE]Related articles

Double-stranded RNA-dependent protein kinase is not required for double-stranded RNA-induced nitric oxide synthase expression or nuclear factor-kappaB activation by islets.

Blair LA, Heitmeier MR, Scarim AL, Maggi LB Jr, Corbett JA.

Diabetes. 2001 Feb;50(2):283-90.PMID: 11272138 [PubMed - indexed for MEDLINE]Related articlesFree article

TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide.

Cetkovic-Cvrlje M, Eizirik DL.

Cytokine. 1994 Jul;6(4):399-406.PMID: 7948748 [PubMed - indexed for MEDLINE]Related articles

Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.

Liu D, Darville M, Eizirik DL.

Endocrinology. 2001 Jun;142(6):2593-9.PMID: 11356709 [PubMed - indexed for MEDLINE]Related articlesFree article

Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells.

Dupraz P, Cottet S, Hamburger F, Dolci W, Felley-Bosco E, Thorens B.

J Biol Chem. 2000 Dec 1;275(48):37672-8.PMID: 10967106 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis.

Scarim AL, Arnush M, Blair LA, Concepcion J, Heitmeier MR, Scheuner D, Kaufman RJ, Ryerse J, Buller RM, Corbett JA.

Am J Pathol. 2001 Jul;159(1):273-83.PMID: 11438474 [PubMed - indexed for MEDLINE]Related articlesFree article

Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS- expressing cells and relationships to cytokines expressed in the islets.

Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC.

Endocrinology. 1996 May;137(5):2093-9.PMID: 8612552 [PubMed - indexed for MEDLINE]Related articles

Role of interferon regulatory factor-1 in double-stranded RNA-induced iNOS expression by mouse islets.

Blair LA, Maggi LB Jr, Scarim AL, Corbett JA.

J Biol Chem. 2002 Jan 4;277(1):359-65. Epub 2001 Nov 1.PMID: 11694524 [PubMed - indexed for MEDLINE]Related articlesFree article

Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.

Chen G, Hohmeier HE, Gasa R, Tran VV, Newgard CB.

Diabetes. 2000 Apr;49(4):562-70.PMID: 10871193 [PubMed - indexed for MEDLINE]Related articlesFree article

Interferon-gamma-induced interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production.

Flodström M, Eizirik DL.

Endocrinology. 1997 Jul;138(7):2747-53.PMID: 9202213 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.

Hong TP, Andersen NA, Nielsen K, Karlsen AE, Fantuzzi G, Eizirik DL, Dinarello CA, Mandrup-Poulsen T.

Eur Cytokine Netw. 2000 Jun;11(2):193-205.PMID: 10903798 [PubMed - indexed for MEDLINE]Related articles

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

Liu D, Pavlovic D, Chen MC, Flodström M, Sandler S, Eizirik DL.

Diabetes. 2000 Jul;49(7):1116-22.PMID: 10909967 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta-cell damage mediated by beta-cell production of interleukin-1. A novel mechanism for virus-induced diabetes.

Heitmeier MR, Arnush M, Scarim AL, Corbett JA.

J Biol Chem. 2001 Apr 6;276(14):11151-8. Epub 2000 Dec 6.PMID: 11108714 [PubMed - indexed for MEDLINE]Related articlesFree article