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    Results: 1 to 20 of 195

    1.

    Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin.

    Huang B, Wu P, Bowker-Kinley MM, Harris RA.

    Diabetes. 2002 Feb;51(2):276-83.PMID: 11812733 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.

    Sugden MC, Bulmer K, Augustine D, Holness MJ.

    Diabetes. 2001 Dec;50(12):2729-36.PMID: 11723055 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.

    Holness MJ, Bulmer K, Smith ND, Sugden MC.

    Biochem J. 2003 Feb 1;369(Pt 3):687-95.PMID: 12435272 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes.

    Wu P, Inskeep K, Bowker-Kinley MM, Popov KM, Harris RA.

    Diabetes. 1999 Aug;48(8):1593-9.PMID: 10426378 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding.

    Sugden MC, Bulmer K, Gibbons GF, Holness MJ.

    Arch Biochem Biophys. 2001 Nov 15;395(2):246-52.PMID: 11697863 [PubMed - indexed for MEDLINE]Related articles

    6.

    Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells.

    Abbot EL, McCormack JG, Reynet C, Hassall DG, Buchan KW, Yeaman SJ.

    FEBS J. 2005 Jun;272(12):3004-14.PMID: 15955060 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.

    Sugden MC, Holness MJ.

    Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul;2(2):151-65. Review.PMID: 12476789 [PubMed - indexed for MEDLINE]Related articles

    8.

    PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity.

    Li S, Wu P, Yarlagadda P, Vadjunec NM, Proia AD, Harris RA, Portilla D.

    Am J Physiol Renal Physiol. 2004 Mar;286(3):F572-80. Epub 2003 Nov 11.PMID: 14612380 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.

    Wu P, Peters JM, Harris RA.

    Biochem Biophys Res Commun. 2001 Sep 21;287(2):391-6.PMID: 11554740 [PubMed - indexed for MEDLINE]Related articles

    10.

    Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism.

    Holness MJ, Smith ND, Bulmer K, Hopkins T, Gibbons GF, Sugden MC.

    Biochem J. 2002 Jun 15;364(Pt 3):687-94.PMID: 12049632 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues.

    Wu P, Blair PV, Sato J, Jaskiewicz J, Popov KM, Harris RA.

    Arch Biochem Biophys. 2000 Sep 1;381(1):1-7.PMID: 11019813 [PubMed - indexed for MEDLINE]Related articles

    12.

    Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression.

    Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA.

    J Biol Chem. 2006 Dec 29;281(52):39897-906. Epub 2006 Nov 1.PMID: 17079227 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart.

    Wu P, Sato J, Zhao Y, Jaskiewicz J, Popov KM, Harris RA.

    Biochem J. 1998 Jan 1;329 ( Pt 1):197-201.PMID: 9405294 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha).

    Holness MJ, Bulmer K, Gibbons GF, Sugden MC.

    Biochem J. 2002 Sep 15;366(Pt 3):839-46.PMID: 12099888 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors.

    Kwon HS, Huang B, Unterman TG, Harris RA.

    Diabetes. 2004 Apr;53(4):899-910.PMID: 15047604 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.

    Hopkins TA, Sugden MC, Holness MJ, Kozak R, Dyck JR, Lopaschuk GD.

    Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H270-6. Epub 2003 Mar 27.PMID: 12663261 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases.

    Sugden MC, Holness MJ.

    Arch Physiol Biochem. 2006 Jul;112(3):139-49. Review.PMID: 17132539 [PubMed - indexed for MEDLINE]Related articles

    18.

    Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor.

    Savkur RS, Bramlett KS, Michael LF, Burris TP.

    Biochem Biophys Res Commun. 2005 Apr 1;329(1):391-6.PMID: 15721319 [PubMed - indexed for MEDLINE]Related articles

    19.

    Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxisomal proliferator-activated receptor (PPAR) in hepatic cells. Hormonal modulation of fatty-acid-induced transcription.

    Steineger HH, Sørensen HN, Tugwood JD, Skrede S, Spydevold O, Gautvik KM.

    Eur J Biochem. 1994 Nov 1;225(3):967-74.PMID: 7957233 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Increased expression of hepatic pyruvate dehydrogenase kinases 2 and 4 in young and middle-aged Otsuka Long-Evans Tokushima Fatty rats: induction by elevated levels of free fatty acids.

    Bajotto G, Murakami T, Nagasaki M, Qin B, Matsuo Y, Maeda K, Ohashi M, Oshida Y, Sato Y, Shimomura Y.

    Metabolism. 2006 Mar;55(3):317-23.PMID: 16483874 [PubMed - indexed for MEDLINE]Related articles

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