PubMed

Overexpression of metallothionein reduces diabetic cardiomyopathy.

Liang Q, Carlson EC, Donthi RV, Kralik PM, Shen X, Epstein PN.

Diabetes. 2002 Jan;51(1):174-81.PMID: 11756338 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic cardiomyopathy and its prevention by metallothionein: experimental evidence, possible mechanisms and clinical implications.

Cai L.

Curr Med Chem. 2007;14(20):2193-203. Review.PMID: 17691957 [PubMed - indexed for MEDLINE]Related articles

Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy.

Cai L, Wang Y, Zhou G, Chen T, Song Y, Li X, Kang YJ.

J Am Coll Cardiol. 2006 Oct 17;48(8):1688-97. Epub 2006 Sep 27.PMID: 17045908 [PubMed - indexed for MEDLINE]Related articles

Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart.

Zhou G, Li X, Hein DW, Xiang X, Marshall JP, Prabhu SD, Cai L.

J Am Coll Cardiol. 2008 Aug 19;52(8):655-66.PMID: 18702970 [PubMed - indexed for MEDLINE]Related articles

Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy.

Shen X, Zheng S, Metreveli NS, Epstein PN.

Diabetes. 2006 Mar;55(3):798-805.PMID: 16505246 [PubMed - indexed for MEDLINE]Related articlesFree article

Podocyte-specific overexpression of the antioxidant metallothionein reduces diabetic nephropathy.

Zheng S, Carlson EC, Yang L, Kralik PM, Huang Y, Epstein PN.

J Am Soc Nephrol. 2008 Nov;19(11):2077-85. Epub 2008 Jul 16.PMID: 18632844 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA.

Duan J, Zhang HY, Adkins SD, Ren BH, Norby FL, Zhang X, Benoit JN, Epstein PN, Ren J.

Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E366-76.PMID: 12531745 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production.

Ye G, Metreveli NS, Ren J, Epstein PN.

Diabetes. 2003 Mar;52(3):777-83.PMID: 12606520 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of nitrative damage by metallothionein in diabetic heart contributes to the prevention of cardiomyopathy.

Cai L.

Free Radic Biol Med. 2006 Sep 15;41(6):851-61. Epub 2006 Jun 15. Review.PMID: 16934665 [PubMed - indexed for MEDLINE]Related articles

Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes.

Ye G, Metreveli NS, Donthi RV, Xia S, Xu M, Carlson EC, Epstein PN.

Diabetes. 2004 May;53(5):1336-43.PMID: 15111504 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation.

Wang J, Song Y, Elsherif L, Song Z, Zhou G, Prabhu SD, Saari JT, Cai L.

Circulation. 2006 Jan 31;113(4):544-54. Epub 2006 Jan 23.PMID: 16432057 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein inhibits myocardial apoptosis in copper-deficient mice: role of atrial natriuretic peptide.

Kang YJ, Zhou ZX, Wu H, Wang GW, Saari JT, Klein JB.

Lab Invest. 2000 May;80(5):745-57.PMID: 10830785 [PubMed - indexed for MEDLINE]Related articles

Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy.

Trost SU, Belke DD, Bluhm WF, Meyer M, Swanson E, Dillmann WH.

Diabetes. 2002 Apr;51(4):1166-71.PMID: 11916940 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury.

Song Y, Wang J, Li Y, Du Y, Arteel GE, Saari JT, Kang YJ, Cai L.

Am J Pathol. 2005 Jul;167(1):17-26.PMID: 15972948 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial overexpression of adenine nucleotide translocase 1 ameliorates diabetic cardiomyopathy in mice.

Wang Y, Ebermann L, Sterner-Kock A, Wika S, Schultheiss HP, Dörner A, Walther T.

Exp Physiol. 2009 Feb;94(2):220-7. Epub 2008 Oct 22.PMID: 18945756 [PubMed - indexed for MEDLINE]Related articles

Cardiomyocyte dysfunction in models of type 1 and type 2 diabetes.

Kralik PM, Ye G, Metreveli NS, Shem X, Epstein PN.

Cardiovasc Toxicol. 2005;5(3):285-92. Erratum in: Cardiovasc Toxicol. 2006;6(1):79. Kralik, Patricia M [added]; Donthi, Rajakumar V [removed]; Shem, Xia [added]. PMID: 16244373 [PubMed - indexed for MEDLINE]Related articles

Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling.

Wang Y, Feng W, Xue W, Tan Y, Hein DW, Li XK, Cai L.

Diabetes. 2009 Jun;58(6):1391-402. Epub 2009 Mar 26.PMID: 19324938 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiomyocyte defects in diabetic models and protection with cardiac-targeted transgenes.

Shen X, Ye G, Metreveli NS, Epstein PN.

Methods Mol Med. 2005;112:379-88. Review.PMID: 16010031 [PubMed - indexed for MEDLINE]Related articles

Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice.

Ueno M, Suzuki J, Zenimaru Y, Takahashi S, Koizumi T, Noriki S, Yamaguchi O, Otsu K, Shen WJ, Kraemer FB, Miyamori I.

Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1109-18. Epub 2008 Apr 15.PMID: 18413675 [PubMed - indexed for MEDLINE]Related articlesFree article

A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy.

Liang Q, Carlson EC, Borgerding AJ, Epstein PN.

J Pharmacol Exp Ther. 1999 Nov;291(2):766-72.PMID: 10525098 [PubMed - indexed for MEDLINE]Related articlesFree article