PubMed

Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals.

Eto K, Yamashita T, Tsubamoto Y, Terauchi Y, Hirose K, Kubota N, Yamashita S, Taka J, Satoh S, Sekihara H, Tobe K, Iino M, Noda M, Kimura S, Kadowaki T.

Diabetes. 2002 Jan;51(1):87-97.PMID: 11756327 [PubMed - indexed for MEDLINE]Related articlesFree article

Wortmannin inhibits insulin secretion in pancreatic islets and beta-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase.

Gao Z, Konrad RJ, Collins H, Matschinsky FM, Rothenberg PL, Wolf BA.

Diabetes. 1996 Jul;45(7):854-62.PMID: 8666133 [PubMed - indexed for MEDLINE]Related articles

Inhibitors of phosphatidylinositol 3-kinase amplify insulin release from islets of lean but not obese mice.

Zawalich WS, Tesz GJ, Zawalich KC.

J Endocrinol. 2002 Aug;174(2):247-58.PMID: 12176663 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of gene expression by glucose in pancreatic beta -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase.

da Silva Xavier G, Varadi A, Ainscow EK, Rutter GA.

J Biol Chem. 2000 Nov 17;275(46):36269-77.PMID: 10967119 [PubMed - indexed for MEDLINE]Related articlesFree article

BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner.

Zhang F, Dey D, Bränström R, Forsberg L, Lu M, Zhang Q, Sjöholm A.

Am J Physiol Cell Physiol. 2009 Feb;296(2):C346-54. Epub 2008 Dec 3.PMID: 19052259 [PubMed - indexed for MEDLINE]Related articles

Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion.

Nogueira TC, Anhê GF, Carvalho CR, Curi R, Bordin S, Carpinelli AR.

Pancreas. 2008 Oct;37(3):309-15.PMID: 18815554 [PubMed - indexed for MEDLINE]Related articles

Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells.

Roper MG, Qian WJ, Zhang BB, Kulkarni RN, Kahn CR, Kennedy RT.

Diabetes. 2002 Feb;51 Suppl 1:S43-9.PMID: 11815457 [PubMed - indexed for MEDLINE]Related articlesFree article

Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.

Høy M, Olsen HL, Andersen HS, Bokvist K, Buschard K, Hansen J, Jacobsen P, Petersen JS, Rorsman P, Gromada J.

Eur J Pharmacol. 2003 Apr 11;466(1-2):213-21.PMID: 12679159 [PubMed - indexed for MEDLINE]Related articles

Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.

Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR.

J Biol Chem. 2003 Nov 28;278(48):48453-66. Epub 2003 Sep 22.PMID: 14504291 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphatidylinositol 3-kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells.

Collier JJ, White SM, Dick GM, Scott DK.

Biochem Biophys Res Commun. 2004 Nov 19;324(3):1018-23.PMID: 15485656 [PubMed - indexed for MEDLINE]Related articles

A link between insulin resistance and hyperinsulinemia: inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean, but not obese, rats.

Zawalich WS, Zawalich KC.

Endocrinology. 2000 Sep;141(9):3287-95.PMID: 10965900 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of protein-tyrosine phosphatases stimulates insulin secretion in pancreatic islets of diabetic Goto-Kakizaki rats.

Chen J, Ostenson CG.

Pancreas. 2005 May;30(4):314-7.PMID: 15841039 [PubMed - indexed for MEDLINE]Related articles

Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

MacDonald PE, Joseph JW, Yau D, Diao J, Asghar Z, Dai F, Oudit GY, Patel MM, Backx PH, Wheeler MB.

Endocrinology. 2004 Sep;145(9):4078-83. Epub 2004 Jul 1.PMID: 15231713 [PubMed - indexed for MEDLINE]Related articlesFree article

The oscillatory behavior of pancreatic islets from mice with mitochondrial glycerol-3-phosphate dehydrogenase knockout.

Ravier MA, Eto K, Jonkers FC, Nenquin M, Kadowaki T, Henquin JC.

J Biol Chem. 2000 Jan 21;275(3):1587-93.PMID: 10636849 [PubMed - indexed for MEDLINE]Related articlesFree article

Wortmannin, a PI3-kinase inhibitor: promoting effect on insulin secretion from pancreatic beta cells through a cAMP-dependent pathway.

Nunoi K, Yasuda K, Tanaka H, Kubota A, Okamoto Y, Adachi T, Shihara N, Uno M, Xu LM, Kagimoto S, Seino Y, Yamada Y, Tsuda K.

Biochem Biophys Res Commun. 2000 Apr 21;270(3):798-805.PMID: 10772905 [PubMed - indexed for MEDLINE]Related articles

Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.

Lee JW, Swick AG, Romsos DR.

Exp Biol Med (Maywood). 2003 Feb;228(2):175-82.PMID: 12563024 [PubMed - indexed for MEDLINE]Related articlesFree article

Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.

Nenquin M, Szollosi A, Aguilar-Bryan L, Bryan J, Henquin JC.

J Biol Chem. 2004 Jul 30;279(31):32316-24. Epub 2004 Jun 1.PMID: 15175349 [PubMed - indexed for MEDLINE]Related articlesFree article

Bimodal role of conventional protein kinase C in insulin secretion from rat pancreatic beta cells.

Zhang H, Nagasawa M, Yamada S, Mogami H, Suzuki Y, Kojima I.

J Physiol. 2004 Nov 15;561(Pt 1):133-47. Epub 2004 Sep 23.PMID: 15388777 [PubMed - indexed for MEDLINE]Related articlesFree article

SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells.

Arredouani A, Guiot Y, Jonas JC, Liu LH, Nenquin M, Pertusa JA, Rahier J, Rolland JF, Shull GE, Stevens M, Wuytack F, Henquin JC, Gilon P.

Diabetes. 2002 Nov;51(11):3245-53.PMID: 12401716 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone reverses insulin secretion altered by chronic exposure to free fatty acid via IRS-2-associated phosphatidylinositol 3-kinase pathway.

Yang L, An HX, Deng XL, Chen LL, Li ZY.

Acta Pharmacol Sin. 2003 May;24(5):429-34.PMID: 12740178 [PubMed - indexed for MEDLINE]Related articlesFree article