PubMed

Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats.

Lin JM, Ortsäter H, Fakhrai-Rad H, Galli J, Luthman H, Bergsten P.

Diabetes. 2001 Dec;50(12):2737-43.PMID: 11723056 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathophysiological and genetic characterization of the major diabetes locus in GK rats.

Galli J, Fakhrai-Rad H, Kamel A, Marcus C, Norgren S, Luthman H.

Diabetes. 1999 Dec;48(12):2463-70.PMID: 10580437 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats.

Fakhrai-Rad H, Nikoshkov A, Kamel A, Fernström M, Zierath JR, Norgren S, Luthman H, Galli J.

Hum Mol Genet. 2000 Sep 1;9(14):2149-58.PMID: 10958757 [PubMed - indexed for MEDLINE]Related articlesFree article

A defective stimulus-secretion coupling rather than glucotoxicity mediates the impaired insulin secretion in the mildly diabetic F1 hybrids of GK-Wistar rats.

Abdel-Halim SM, Ostenson CG, Andersson A, Jansson L, Efendić S.

Diabetes. 1995 Nov;44(11):1280-4.PMID: 7589824 [PubMed - indexed for MEDLINE]Related articles

Separately inherited defects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes.

Granhall C, Rosengren AH, Renström E, Luthman H.

Diabetes. 2006 Dec;55(12):3494-500.PMID: 17130497 [PubMed - indexed for MEDLINE]Related articlesFree article

Preserved initiatory and potentiatory effect of alpha-ketoisocaproate on insulin release in islets of glucose intolerant rats.

Guenifi A, Abdel-Halim SM, Efendic S, Ostenson CG.

Diabetologia. 1998 Nov;41(11):1368-73.PMID: 9833946 [PubMed - indexed for MEDLINE]Related articles

Oscillations in oxygen tension and insulin release of individual pancreatic ob/ob mouse islets.

Ortsäter H, Liss P, Lund PE, Akerman KE, Bergsten P.

Diabetologia. 2000 Oct;43(10):1313-8.PMID: 11079751 [PubMed - indexed for MEDLINE]Related articles

Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: a defect ameliorated by cAMP.

Abdel-Halim SM, Guenifi A, Khan A, Larsson O, Berggren PO, Ostenson CG, Efendić S.

Diabetes. 1996 Jul;45(7):934-40.PMID: 8666145 [PubMed - indexed for MEDLINE]Related articles

High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals<800 kb in the species-conserved Niddm1i of the GK rat.

Granhall C, Park HB, Fakhrai-Rad H, Luthman H.

Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1.PMID: 16951059 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of islet secretory function in the development of diabetes in the GK Wistar rat.

Hughes SJ, Suzuki K, Goto Y.

Diabetologia. 1994 Sep;37(9):863-70.PMID: 7806015 [PubMed - indexed for MEDLINE]Related articles

Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetics GK rats and its defective augmentation by glucose.

Okamoto Y, Ishida H, Tsuura Y, Yasuda K, Kato S, Matsubara H, Nishimura M, Mizuno N, Ikeda H, Seino Y.

Diabetologia. 1995 Jul;38(7):772-8.PMID: 7556977 [PubMed - indexed for MEDLINE]Related articles

Inhibition of protein-tyrosine phosphatases stimulates insulin secretion in pancreatic islets of diabetic Goto-Kakizaki rats.

Chen J, Ostenson CG.

Pancreas. 2005 May;30(4):314-7.PMID: 15841039 [PubMed - indexed for MEDLINE]Related articles

Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretion.

Nagamatsu S, Nakamichi Y, Yamamura C, Matsushima S, Watanabe T, Ozawa S, Furukawa H, Ishida H.

Diabetes. 1999 Dec;48(12):2367-73.PMID: 10580425 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat.

Ostenson CG, Khan A, Abdel-Halim SM, Guenifi A, Suzuki K, Goto Y, Efendic S.

Diabetologia. 1993 Jan;36(1):3-8.PMID: 8436249 [PubMed - indexed for MEDLINE]Related articles

Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

Nesher R, Warwar N, Khan A, Efendic S, Cerasi E, Kaiser N.

Diabetes. 2001 Feb;50(2):308-14.PMID: 11272141 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes.

Giroix MH, Vesco L, Portha B.

Endocrinology. 1993 Feb;132(2):815-22.PMID: 8425496 [PubMed - indexed for MEDLINE]Related articles

Pulsatile insulin release from islets isolated from three subjects with type 2 diabetes.

Lin JM, Fabregat ME, Gomis R, Bergsten P.

Diabetes. 2002 Apr;51(4):988-93.PMID: 11916916 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets.

Ueda K, Tanizawa Y, Ishihara H, Kizuki N, Ohta Y, Matsutani A, Oka Y.

Diabetologia. 1998 Jun;41(6):649-53.PMID: 9662045 [PubMed - indexed for MEDLINE]Related articles

Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.

Wallis RH, Wallace KJ, Collins SC, McAteer M, Argoud K, Bihoreau MT, Kaisaki PJ, Gauguier D.

Diabetologia. 2004 Jun;47(6):1096-106. Epub 2004 May 26.PMID: 15164172 [PubMed - indexed for MEDLINE]Related articles

Impact of diabetic inheritance on glucose tolerance and insulin secretion in spontaneously diabetic GK-Wistar rats.

Abdel-Halim SM, Guenifi A, Luthman H, Grill V, Efendic S, Ostenson CG.

Diabetes. 1994 Feb;43(2):281-8.PMID: 8288052 [PubMed - indexed for MEDLINE]Related articles